Synthesis and in vitro antibacterial evaluation of some thiosemicarbazides and thiosemicarbazones

Morasa Sheikhy, Amir R. Jalilian, Aytak Novinrooz, Farahnaz Motamedi-Sedeh

Agricultural, Medical and Industrial Research School, Nuclear Science and Technology Research Institute (AMIRS-NSTRI), Karaj, Iran.
Faculty of Pharmacy, Islamic Azad University of Pharmaceutical Sciences, Tehran, Iran.

DOI: 10.4236/jbise.2012.52006                

Abstract

In the present study various thiosemicarbazides and thiosemicarbazones were synthesized and screened for their antimicrobial activity. Among the ligands tested, compounds 1, 3, 4 and 5 demonstrated inhibitory effects at 0.4 - 0.5 μM concentrations against E. coli while 1-(4-fluorobenzoyl)-N4-ethyl-thiosemicar-bazide (3) demonstrated the maximum inhibitory effective compound against E. coli, also possessing high water solubility. Instead, compound 3 demonstrated weak antibiotic effects against S. aurous while compounds 4 - 6 demonstrated significant antibacterial effects at 0.4 - 0.42 μM against the latter organism. Chloramphenicol was used as the positive control.

Keywords

Synthesis; Antibacterial; Thiosemicarbazides; Thiosemi-carbazones

Conflicts of Interest

The authors declare no conflicts of interest.

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