Transdermal drug delivery models

Grantham K. H. Pang, Da-Peng Qiao

.

DOI: 10.4236/jbise.2010.34051                

Abstract

In this paper, a preliminary study based on the different models of the skin impedance is carried out. The purpose is to examine the drug delivery method through iontophoresis, which relies on active trans- portation of the charged medication agent within an electric field. It is a kind of transdermal drug delivery method, and hence the method has to handle the variability in skin characteristics of a patient. This paper carries out a simulation study based on three different skin impedance models.

Keywords

Target Drug Delivery; Biomedical Engineering; Skin Impedance; Iontophoresis

Conflicts of Interest

The authors declare no conflicts of interest.

References

[1]	Stoebar, B. and Liepmann, D. (2005) Array of hollow out-of-plane microneedles for drug delivery. Journal of MEMS, 14(3), 474-479.
[2]	Ji, J., Tay, F.E.H., Miao, J. and Iliescu, C. (2006) Micro- fabricated microneedles with porous tip for drug delivery. Journal of Micromechanics and Microengineering, 16, 958- 964.
[3]	Lam, D.C.C., Lee, Y.H., Shek, K.T. and Pang, G. (2008) Puncture depth and the mechanical stability of micro- needles. International Joint Conference on Biomedical Engineering Systems and Technologies, 2, 291-296.
[4]	Coston, A.F. and Li, J.K.-J. (2001) Iontophoresis: Model- ling, methodology, and evaluation. Cardiovascular Engineering, 1, 127-136.
[5]	Coston, A.F. and Li, J.K.-J. (2003) Transdermal drug delivery: A comparative analysis of skin impedance mo- dels and parameters. Proceedings of IEEE Engineering in Medicine and Biology, 3, 2982-2985.
[6]	Lawler, J.C., Davis, M.J. and Griffith, E.C. (1960) Elec- trical characteristics of the skin: The impedance of the surface sheath and deep tissues. Journal of Investigative Dermatology, 34, 301-308.
[7]	Edelberg, R. (1971) Electrical properties of skin. In El- den, H.R. Ed., Biophysical properties of the skin, John Wiley & Sons, Inc, New York.
[8]	Tregear, R.T. (1966) Physical functions of the skin. Aca- demic Press, New York.
[9]	Lykken, D.T. (1970) Square-wave analysis of skin impedance. Psychophysiology, 7(2), 262-275.