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No relationship between the incidence of fentanyl-induced cough and smoking

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DOI: 10.4236/health.2009.13031    3,935 Downloads   7,181 Views   Citations


The purpose of the study was to investigate whether or not the incidence of cough after intra-venous fentanyl depends on the patient’s smoking state and the speed of injection. 530 ASA class I-III patients free of bronchial hyperreactivity and res-piratory tract infection undergoing general anes-thesia for elective surgery were randomized to 1.5 fentanyl injected over 2, 5 or 10 sec or pla-cebo via a peripheral intravenous cannula. The endpoint was cough within 5 min after completion of injection. Statistical evaluation was performed by factorial ANOVA and chi-square-test. Assuming around 25% smokers in our patient population calculated patient sample size was 340 per group. The study was terminated for futility after enrol-ment of 530 patients since an interims analysis yielded an incidence of cough of 2 % both in smokers (n=174) and nonsmokers (n=356, p= 0,970), which was unrelated to the speed of injec-tion and not different from placebo.

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The authors declare no conflicts of interest.

Cite this paper

Pokhis, B. and Hopf, H. (2009) No relationship between the incidence of fentanyl-induced cough and smoking. Health, 1, 188-191. doi: 10.4236/health.2009.13031.


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