Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography for Osteochondromas Utilizing a Triple-Time Point Protocol

Chris Sambaziotis, Andrew Lovy, Renee M. Moadel, Murthy Chamarthy, Joseph Glaser, Srividya Jaini, Esperanza Villanueva-Siles, David S. Geller

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DOI: 10.4236/ojmi.2011.12003                

Abstract

Purpose: The purpose of this study was to assess solitary osteochondroma and hereditary multiple osteochondral exostoses (HMOCE) utilizing FDG PET and a triple time point protocol. Methods: Seven patients were consented and recruited for PET evaluation of presumed benign osteochondroma. Following injection of 15 mCi of FDG, the lesion(s) of interest was imaged with PET-CT at 45 minutes post injection, whole body at 50 minutes post, and lesion of interest at 95 minutes post injection. A maximum standardized uptake value (SUV_max) was obtained for the lesion(s) of interest at each time point, and an SUV_Δ was calculated for each lesion of interest from the first time point to the third time point. Results: 16 lesions from 7 patients were included in the study. Mean SUV_max for all 3 time points was 1.04 with a standard deviation of 0.50 (range 0.3 - 2.2). The mean SUV was 0.096 with a range of 0 - 0.4. Among the 3 patients with histologically confirmed osteochondromas, mean SUV_max was 0.67, with standard deviation of 0.23 and range of 0.3 to 1.0. The mean SUV_Δ13 was 0.081 (range 0 - 0.4), mean SUV_Δ12 was 0.10 (0 - 0.3), and mean SUV_Δ23 was 0.11 (range 0 - 0.4) (p = 0.74). Conclusion: Benign lesions were found to not have progressively increasing uptake on multiple time point FDG PET. Until chondrosarcomas are evaluated using triple time point ¹⁸FDG PET, its applicability in the evaluation of osteochondroma versus malignant change remains uncertain.

Keywords

Positron Emission Tomography, Osteochondroma, Chondrosarcoma, Fluorine-18 Fluorodeoxyglucose

Conflicts of Interest

The authors declare no conflicts of interest.

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