Share This Article:

A New Liposomal-Drug-in-Adhesive Patch for Transdermal Delivery of Sodium Diclofenac

Abstract Full-Text HTML Download Download as PDF (Size:1357KB) PP. 576-581
DOI: 10.4236/jbnb.2011.225069    8,164 Downloads   14,963 Views   Citations

ABSTRACT

Liposomes are known to have considerable potential as drug carriers such as liposomal suspension, freeze dried and cream-based systems among many other liposomal formulations. In this study a new drug-in-adhesive patch was fabricated using liposome-based nanocarrier. Transfersomes as ultra-deformable liposomes are based on phosphatidylcholin 95% (phospholipon 90G) and phosphatidylcholin 50% (phosal 50PG) were prepared and further optimized in a final acrylic patch system for effective adhesion. The prepared liposomes were added to an acrylic adhesive to obtain a new hybrid transdermal patch termed as “lipo-drug-in-adhesive” patch system. The sodium diclofenac was selected as a model drug and the permeation of the drug across rat skin was evaluated (P > 0.05), using the lipo-drug-in-adhesive patch system with various percentages of transfersomes (4% - 8%w/w) and constant concentration of the drug (2% w/w). The peel strength and tack value of samples were also examined and quantified. The maximum flux of sodium diclofenac was observed in samples containing 8% (w/w) phosphatidylcholin 50%. The peel strength and tack value in samples containing phosphatidylcholin 50% were lower than those samples containing phosphatidylcholin 95%. It was observed that with increased amount of liposome in drug-in-adhesive patch system, the rate of skin permeation of the drug was also increased. It can be concluded that the developed lipo-drug-in-adhesive patch system enhances the drug release potential of transdermal delivering systems.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Taghizadeh, S. and Bajgholi, S. (2011) A New Liposomal-Drug-in-Adhesive Patch for Transdermal Delivery of Sodium Diclofenac. Journal of Biomaterials and Nanobiotechnology, 2, 576-581. doi: 10.4236/jbnb.2011.225069.

References

[1] K. B. Ita, J. D. Preez, M. E. Lane, et al., “Dermal Delivery of Selected Hydrophilic Drugs from Elastic Liposomes: Effect of phospholipid Formulation and Surfactants,” Journal of Pharmacy and Pharmacology, Vol. 59, No. 9, 2007, pp. 1215-1222. doi:10.1211/jpp.59.9.0005
[2] M. Manconi, S. Mura, C. Sinico, et al., “Development and Characterization of Liposomes Containing Glycols as Carriers for Diclofenac,” Colloids and Surfaces A: Physicochemical and Engineering Aspects, Vol. 342, No. 1-3, 2009, pp. 53-58. doi:10.1016/j.colsurfa.2009.04.006
[3] L. B. Lopes, M. V. Scarpa and G. V. J. Silva, “Studies on the Encapsulation of Diclofenac in Small Unilamellar Liposomes of Soya Phosphatidylcholin,” Colloids and Surfaces B: Biointerfaces, Vol. 39, No. 4, 2004, pp. 151-158. doi:10.1016/j.colsurfb.2004.09.004
[4] P. Karande and S. Mitragotri, “Enhancement of Transdermal Drug Delivery via Synergistic Action of Chemicals,” Biochimica et Biophysica Acta (BBA)-Biomembranes, Vol. 1788, No. 11, 2009, pp. 2362-2373. doi:10.1016/j.bbamem.2009.08.015
[5] M. M. A. Elsayed, O. Y. Abdallah, V. F. Naggar, et al., “Lipid Vesicles for Skin Delivery of Drugs: Reviewing Three Decades of Research,” International Journal of Pharmaceutics, Vol. 332, No. 1-2, 2007, pp. 1-16. doi:10.1016/j.ijpharm.2006.12.005
[6] J. A. Zhang, G. Anyarambhatla, L. Ma, et al., “Development and Characterization of a Novel Cremophor EL Free Liposome-Based Paclitaxel (LEP-ETU) Formulation,” European Journal of Pharmaceutics and Biopharmaceutics, Vol. 59, No. 1, 2005, pp. 177-187. doi:10.1016/j.ejpb.2004.06.009
[7] K. Shimizu, M. Osada, K. Takemoto, et al., “Temperature-Dependent Transfer of Amphotericin B from Liposomal Membrane of Ambiosome to Fungal Cell Membrane,” Journal of Controlled Release, Vol. 141, No. 2, 2010, pp. 208-215. doi:10.1016/j.jconrel.2009.09.019
[8] C. Ren, L. Fang, L. Ling, et al., “Designand in Vivo Evaluation of an Indapamide Transdermal Patch,” International Journal of Pharmaceutics, Vol. 370, No. 1-2, 2009, pp. 129-135. doi:10.1016/j.ijpharm.2008.12.004
[9] E. Gutschke, S. Bracht, S. Nagel, et al., “Adhesion Testing of Transdermal Matrix Patches with a Probe Tack Test: In Vitro and in Vivo Evaluation,” European Journal of Pharmaceutics and Biopharmaceutics, Vol. 75, No. 3, 2009, pp. 399-404. doi:10.1016/j.ejpb.2010.03.016
[10] T. Garg, S. Jain, S. H. Pal, et al., “Elastic liposomal Formulation for Sustained Delivery of Antimigraine Drugs: In Vitro Characterization and Biological Evaluation,” Drug Development and Industrial Pharmacy, Vol. 34, No. 10, 2008, pp. 1100-1110. doi:10.1080/03639040801965079
[11] A. Mehdizadeh, M. H. Ghahremani, M. R. Rouini, et al., “Effects of Pressure Sensitive Adhesives and Chemical Permeation Enhancers on the Permeability of Fentanyl through Excised Rat Skin,” Acta Pharmaceutica, Vol. 56, No. 2, 2006, pp. 219-229.
[12] B. Vora, A. J. Khopade and N. K. Jain, “Proniosome Based Transdermal Delivery of Levonorgestrel for Effective Contraception,” Journal of Controlled Release, Vol. 54, No. 2, 1998, pp. 149-165. doi:10.1016/S0168-3659(97)00100-4
[13] M. Kincl, M. Meleh, M. Veber, et al., “Study of Physicochemical Parameters Affecting the Release of Diclofenac Sodium from Lipophilic Matrix Tablets,” Acta Chimica Slovenica, Vol. 51, 2004, pp. 409-425.
[14] S. M. Taghizade, A. Soroushnia and F. Mohamadnia, “Preparation and in-Vitro Evaluation of a New Fentanyl Patch Based on Functional and Non-Functional Pressure Sensitive Adhesives,” AAPS PharmSciTech, Vol. 11, No. 1, 2010, pp. 278-284. doi:10.1208/s12249-009-9366-3
[15] S. M. Taghizadeh and D. Ghasemi, “Synthesis and Optimization of a Four-Component Acrylic-Based Copolymer as Pressure Sensitive Adhesive,” Iranian Polymer Journal, Vol. 19, No. 5, 2010, pp. 343-352.
[16] D. D. Verma, S. Verma, G. Blume, et al., “Particle Size of Liposomes In?uences Dermal Delivery of Substances into Skin,” International Journal of Pharmaceutics, Vol. 258, No. 1-2, 2003, pp. 141-151. doi:10.1016/S0378-5173(03)00183-2
[17] R. R. Boinpally, S. L. Zhou, S. Poondru, et al., “Lecithin Vesicles for Topical Delivery of Diclofenac,” European Journal of Pharmaceutics and Biopharmaceutics, Vol. 56, No. 3, 2003, pp. 389-392. doi:10.1016/S0939-6411(03)00143-7
[18] B. EI-Houssieny and H. M. Hamouda, “Formulation and Evaluation of Clotrimazole from Pluronic F127 Gels,” Drug Discoveries & Therapeutics, Vol. 4, 2010, pp. 33- 43.
[19] D. Dhamecha, A. A. Rathi and M. Saifee, “Drug Vehicle Based Approaches of Penetration Enhancement,” International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 1, No. 1, 2009, pp. 24-46.
[20] R. K. Bhardwaj and T. Velpandian, “Effect of Liposomes on Permeation of Diclofenac through Cadaver Skin: In-Vivo Evaluation Using Animal Models,” Journal of Pharmacy and Pharmacology, Vol. 6, No. 11, 2010, pp. 485-489.

  
comments powered by Disqus

Copyright © 2018 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.