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A New Liposomal-Drug-in-Adhesive Patch for Transdermal Delivery of Sodium Diclofenac

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DOI: 10.4236/jbnb.2011.225069    8,164 Downloads   14,963 Views   Citations


Liposomes are known to have considerable potential as drug carriers such as liposomal suspension, freeze dried and cream-based systems among many other liposomal formulations. In this study a new drug-in-adhesive patch was fabricated using liposome-based nanocarrier. Transfersomes as ultra-deformable liposomes are based on phosphatidylcholin 95% (phospholipon 90G) and phosphatidylcholin 50% (phosal 50PG) were prepared and further optimized in a final acrylic patch system for effective adhesion. The prepared liposomes were added to an acrylic adhesive to obtain a new hybrid transdermal patch termed as “lipo-drug-in-adhesive” patch system. The sodium diclofenac was selected as a model drug and the permeation of the drug across rat skin was evaluated (P > 0.05), using the lipo-drug-in-adhesive patch system with various percentages of transfersomes (4% - 8%w/w) and constant concentration of the drug (2% w/w). The peel strength and tack value of samples were also examined and quantified. The maximum flux of sodium diclofenac was observed in samples containing 8% (w/w) phosphatidylcholin 50%. The peel strength and tack value in samples containing phosphatidylcholin 50% were lower than those samples containing phosphatidylcholin 95%. It was observed that with increased amount of liposome in drug-in-adhesive patch system, the rate of skin permeation of the drug was also increased. It can be concluded that the developed lipo-drug-in-adhesive patch system enhances the drug release potential of transdermal delivering systems.

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The authors declare no conflicts of interest.

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Taghizadeh, S. and Bajgholi, S. (2011) A New Liposomal-Drug-in-Adhesive Patch for Transdermal Delivery of Sodium Diclofenac. Journal of Biomaterials and Nanobiotechnology, 2, 576-581. doi: 10.4236/jbnb.2011.225069.


[1] K. B. Ita, J. D. Preez, M. E. Lane, et al., “Dermal Delivery of Selected Hydrophilic Drugs from Elastic Liposomes: Effect of phospholipid Formulation and Surfactants,” Journal of Pharmacy and Pharmacology, Vol. 59, No. 9, 2007, pp. 1215-1222. doi:10.1211/jpp.59.9.0005
[2] M. Manconi, S. Mura, C. Sinico, et al., “Development and Characterization of Liposomes Containing Glycols as Carriers for Diclofenac,” Colloids and Surfaces A: Physicochemical and Engineering Aspects, Vol. 342, No. 1-3, 2009, pp. 53-58. doi:10.1016/j.colsurfa.2009.04.006
[3] L. B. Lopes, M. V. Scarpa and G. V. J. Silva, “Studies on the Encapsulation of Diclofenac in Small Unilamellar Liposomes of Soya Phosphatidylcholin,” Colloids and Surfaces B: Biointerfaces, Vol. 39, No. 4, 2004, pp. 151-158. doi:10.1016/j.colsurfb.2004.09.004
[4] P. Karande and S. Mitragotri, “Enhancement of Transdermal Drug Delivery via Synergistic Action of Chemicals,” Biochimica et Biophysica Acta (BBA)-Biomembranes, Vol. 1788, No. 11, 2009, pp. 2362-2373. doi:10.1016/j.bbamem.2009.08.015
[5] M. M. A. Elsayed, O. Y. Abdallah, V. F. Naggar, et al., “Lipid Vesicles for Skin Delivery of Drugs: Reviewing Three Decades of Research,” International Journal of Pharmaceutics, Vol. 332, No. 1-2, 2007, pp. 1-16. doi:10.1016/j.ijpharm.2006.12.005
[6] J. A. Zhang, G. Anyarambhatla, L. Ma, et al., “Development and Characterization of a Novel Cremophor EL Free Liposome-Based Paclitaxel (LEP-ETU) Formulation,” European Journal of Pharmaceutics and Biopharmaceutics, Vol. 59, No. 1, 2005, pp. 177-187. doi:10.1016/j.ejpb.2004.06.009
[7] K. Shimizu, M. Osada, K. Takemoto, et al., “Temperature-Dependent Transfer of Amphotericin B from Liposomal Membrane of Ambiosome to Fungal Cell Membrane,” Journal of Controlled Release, Vol. 141, No. 2, 2010, pp. 208-215. doi:10.1016/j.jconrel.2009.09.019
[8] C. Ren, L. Fang, L. Ling, et al., “Designand in Vivo Evaluation of an Indapamide Transdermal Patch,” International Journal of Pharmaceutics, Vol. 370, No. 1-2, 2009, pp. 129-135. doi:10.1016/j.ijpharm.2008.12.004
[9] E. Gutschke, S. Bracht, S. Nagel, et al., “Adhesion Testing of Transdermal Matrix Patches with a Probe Tack Test: In Vitro and in Vivo Evaluation,” European Journal of Pharmaceutics and Biopharmaceutics, Vol. 75, No. 3, 2009, pp. 399-404. doi:10.1016/j.ejpb.2010.03.016
[10] T. Garg, S. Jain, S. H. Pal, et al., “Elastic liposomal Formulation for Sustained Delivery of Antimigraine Drugs: In Vitro Characterization and Biological Evaluation,” Drug Development and Industrial Pharmacy, Vol. 34, No. 10, 2008, pp. 1100-1110. doi:10.1080/03639040801965079
[11] A. Mehdizadeh, M. H. Ghahremani, M. R. Rouini, et al., “Effects of Pressure Sensitive Adhesives and Chemical Permeation Enhancers on the Permeability of Fentanyl through Excised Rat Skin,” Acta Pharmaceutica, Vol. 56, No. 2, 2006, pp. 219-229.
[12] B. Vora, A. J. Khopade and N. K. Jain, “Proniosome Based Transdermal Delivery of Levonorgestrel for Effective Contraception,” Journal of Controlled Release, Vol. 54, No. 2, 1998, pp. 149-165. doi:10.1016/S0168-3659(97)00100-4
[13] M. Kincl, M. Meleh, M. Veber, et al., “Study of Physicochemical Parameters Affecting the Release of Diclofenac Sodium from Lipophilic Matrix Tablets,” Acta Chimica Slovenica, Vol. 51, 2004, pp. 409-425.
[14] S. M. Taghizade, A. Soroushnia and F. Mohamadnia, “Preparation and in-Vitro Evaluation of a New Fentanyl Patch Based on Functional and Non-Functional Pressure Sensitive Adhesives,” AAPS PharmSciTech, Vol. 11, No. 1, 2010, pp. 278-284. doi:10.1208/s12249-009-9366-3
[15] S. M. Taghizadeh and D. Ghasemi, “Synthesis and Optimization of a Four-Component Acrylic-Based Copolymer as Pressure Sensitive Adhesive,” Iranian Polymer Journal, Vol. 19, No. 5, 2010, pp. 343-352.
[16] D. D. Verma, S. Verma, G. Blume, et al., “Particle Size of Liposomes In?uences Dermal Delivery of Substances into Skin,” International Journal of Pharmaceutics, Vol. 258, No. 1-2, 2003, pp. 141-151. doi:10.1016/S0378-5173(03)00183-2
[17] R. R. Boinpally, S. L. Zhou, S. Poondru, et al., “Lecithin Vesicles for Topical Delivery of Diclofenac,” European Journal of Pharmaceutics and Biopharmaceutics, Vol. 56, No. 3, 2003, pp. 389-392. doi:10.1016/S0939-6411(03)00143-7
[18] B. EI-Houssieny and H. M. Hamouda, “Formulation and Evaluation of Clotrimazole from Pluronic F127 Gels,” Drug Discoveries & Therapeutics, Vol. 4, 2010, pp. 33- 43.
[19] D. Dhamecha, A. A. Rathi and M. Saifee, “Drug Vehicle Based Approaches of Penetration Enhancement,” International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 1, No. 1, 2009, pp. 24-46.
[20] R. K. Bhardwaj and T. Velpandian, “Effect of Liposomes on Permeation of Diclofenac through Cadaver Skin: In-Vivo Evaluation Using Animal Models,” Journal of Pharmacy and Pharmacology, Vol. 6, No. 11, 2010, pp. 485-489.

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