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Type I endometrial cancer after chemoradiation therapy for carcinoma of the cervix: a case report

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DOI: 10.4236/ojog.2011.14044    3,111 Downloads   5,800 Views   Citations


Standard treatment for cervical cancer has been radiation and chemotherapy. Ionizing radiation has been associated with damage to normal tissues included in the radiation field. Post-radiation uterine cancers are characterized by high stage, high grade, and a preponderance of type II histologic subtypes. We report a case of type I endometrioid adenocarcinoma diagnosed 19 years after definitive chemoradiation for cervical cancer.

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The authors declare no conflicts of interest.

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Gupta, V. and Hoekstra, A. (2011) Type I endometrial cancer after chemoradiation therapy for carcinoma of the cervix: a case report. Open Journal of Obstetrics and Gynecology, 1, 226-228. doi: 10.4236/ojog.2011.14044.


[1] Chaturvedi, A., Engels, E., Gilbert, E., Chen, B., Storm, H., Lynch, C., et al. (2007) Second cancers among 104,760 survivors of cervical cancer: Evaluation of long-term risk. Journal of National Cancer Institute, 99, 1634-1643. doi:10.1093/jnci/djm201
[2] Kumar, S., Shah, J., Bryant, C., Seward, S., Ali-Fehmi, R., Morris, R., et al. (2009) Radiation-associated endometrial cancer. Obstetrics and Gynecology, 113, 319-325.
[3] Gallion, H., Van Nagell, J., Donaldson, E. and Powell, D. (1987) Endometrial cancer following radiation therapy for cervical cancer. Gynecologic Oncology, 27, 76-83. doi:10.1016/0090-8258(87)90232-0
[4] Pothuri, B., Ramondetta, L., Martino, M., Alektiar, K., Eifel, P., Deavers, M., et al. (2003) Development of endometrial cancer after radiation treatment for cervical carcinoma. Obstetrics and Gynecology, 101, 941-945. doi:10.1016/S0029-7844(03)00234-5
[5] Parkash, V. and Carcangiu, M.L. (1992) Uterine Papillary serous carcinoma after radiation therapy for carcinoma of the cervix. Cancer, 69, 496-501. doi:10.1002/1097-0142(19920115)69:2<496::AID-CNCR2820690237>3.0.CO;2-Q
[6] Hagiwara, T., Mori, T. and Kaku, T. (2005) Development of endometrial cancer following radiation therapy for cervical carcinoma. European Journal of Gynaecologic Oncology, 26, 191-195.
[7] Buchholz, T.A. (2003) Lung carcinoma development after radiotherapy for breast carcinoma. Cancer, 98, 1331-1333. doi:10.1002/cncr.11657
[8] Travis, L.B., Hill, D.A., Dores, G.M., et al. (2003) Breast cancer following radiotherapy and chemotherapy among young women with Hodgkin disease. Journal of the American Medical Association, 290, 465-475. doi:10.1001/jama.290.4.465
[9] Pride, G.L. and Buchler, D.A. (1997) Carcinoma of the vagina 10 or more years following pelvic irradiation therapy. American Journal of Obstetrics Gynecology, 127, 513-517.
[10] Jereczek-Fossa, B.A., Alterio, D., Jassem, J., et al. (2004) Radiotherapy-induced thyroid disorders. Cancer Treatment Review, 30, 369-384. doi:10.1016/j.ctrv.2003.12.003
[11] Rodriguez, J. and Hart, W. (1982) Endometrial cancers occurring 10 or more years after pelvic irradiation for carcinoma. International Journal of Gynecological Pathology, 1, 135-144. doi:10.1097/00004347-198202000-00002
[12] Seidman, J.D., Kumar, D., Cosin, J.A., et al. (2006) Carcinomas of the female genital tract occurring after pelvic irradiation: A report of 15 cases. International Journal of Gynecologic Pathology, 25, 293-297. doi:10.1097/01.pgp.0000189240.03780.b1
[13] De Hullu, J.A., Pras, E., Hollema, H., et al. (2005) Presentations of endometrial activity after curative radiotherapy for cervical cancer. Maturitas, 51, 172-176. doi:10.1016/j.maturitas.2004.07.005

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