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New Approaches for the Use of Acetoacetanilide in the Synthesis of Thiophenes and Their Fused Derivatives with Anti-Tumor Activity

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DOI: 10.4236/oalib.1101089    1,211 Downloads   1,522 Views  

ABSTRACT

Acetoacetanilide derivatives 1a-c reacted with either malnonitrile or ethyl cyanoacetate and elemental sulfur to give the thiophene derivatives 3a-f. The reactivity of 3a towards some chemical reagents to give thiophene, theino[2,3-b]pyridine, thieno[2,3-c]pyrimidine and coumarin derivatives was studied. The anti-tumor evaluation of the newly synthesized compounds against the three human tumor cells lines namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) showed that compounds 8a, 8b and 14 exhibit higher inhibitory effects towards the three tumor cell lines than the positive control doxorubicin.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Mohareb, R. , Sherif, S. , Wardakhan, W. and Abouzied, A. (2014) New Approaches for the Use of Acetoacetanilide in the Synthesis of Thiophenes and Their Fused Derivatives with Anti-Tumor Activity. Open Access Library Journal, 1, 1-16. doi: 10.4236/oalib.1101089.

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