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Radiotherapy Intensified by Increase of Fraction Size Using Three-Dimensional Conformal Radiotherapy in Bladder Preservation Therapy

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DOI: 10.4236/jct.2015.611107    2,093 Downloads   2,341 Views  

ABSTRACT

Purpose: The impact of radiotherapy on bladder cancers heightened by increase of fraction size using three-dimensional conformal radiotherapy (3DCRT) was verified with biologically effective dose (BED, Gy10). Method: Twenty-five patients who were considered unsuitable for total cystectomy underwent 3DCRT between 2009 and 2014. When a gross tumor volume (GTV) did not neighbor guts and the patient was cooperative to radiotherapy (radical), the GTV was treated with a fraction size of ≥3.0 Gy, while a clinical target volume (CTV) of a whole bladder and lymph nodes at small pelvis were treated with a conventional fraction size of 2.0 Gy. When a GTV neighbored guts (palliative), only a CTV was treated with an increased fraction size of 2.5 Gy. Results: Compared to conventional two-dimensional radiotherapy, BED increased to 62.3 - 77.0 Gy10 (radical) or to 56.1 - 68.0 Gy10 (palliative) but the treatment period shortened to 4 - 5 weeks. Acute adverse events (≤3 months), determined by common terminology criteria for adverse events, were Grade 2 at most, but late adverse events were not observed. Only one patient (6%) lost the bladder. Conclusions: Patients who receive bladder preservation therapy appear good candidates to intensify impact of radiotherapy with 3DCRT.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Ohara, K. , Oyama, K. , Suzuki, A. , Kawano, K. , Morimoto, S. and Okawa, A. (2015) Radiotherapy Intensified by Increase of Fraction Size Using Three-Dimensional Conformal Radiotherapy in Bladder Preservation Therapy. Journal of Cancer Therapy, 6, 993-999. doi: 10.4236/jct.2015.611107.

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