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Gastric Cancer in Bahrain: A Retrospective Study of Histologically Confirmed Tumours between 2001 and 2007 from the Two Main Bahraini Referral Hospitals

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DOI: 10.4236/ojpathology.2015.54018    3,336 Downloads   3,664 Views  

ABSTRACT

Objective: Few data are available describing the epidemiology and pathology of stomach cancer in Bahrain. Methods: A retrospective study examining all histologically confirmed cases of gastric cancer at the two main referral hospitals in Bahrain during the period 2001-2007. Results: 116 cases of gastric cancer were histologically confirmed in this seven-year period. There were 94 cases (81%) of adenocarcinoma, 10 (8.6%) lymphoma, 7 (6.0%) gastrointestinal stromal tumour, and 5 (4.3%) neuroendocrine tumour. Of the 94 patients with adenocarcinoma 65 (69.1%) were male (p < 0.01). 24 out of 43 intestinal type adenocarcinomas were positive for intestinal metaplasia (p < 0.001). Between 2004 and 2006 when total annual numbers of gastric cancers overall and gastric adenocarcinoma decreased the total numbers of lymphoma increased. Conclusions: The most common type of gastric cancer in Bahrain is adenocarcinoma. There was a reduction in gastric cancers overall and adenocarcinoma during the middle two years of the study, and possible explanations for this were suggested. An association between intestinal metaplasia and intestinal subtype gastric adenocarcinoma was confirmed. The non-carcinoma gastric tumours in Bahrain comprise a small proportion of all gastric tumours and include lymphoma, neuroendocrine tumours and gastrointestinal stromal tumours.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Omran, B. and Ansari, N. (2015) Gastric Cancer in Bahrain: A Retrospective Study of Histologically Confirmed Tumours between 2001 and 2007 from the Two Main Bahraini Referral Hospitals. Open Journal of Pathology, 5, 129-136. doi: 10.4236/ojpathology.2015.54018.

References

[1] Jemal, A., Bray, F., Center, M.M., Ferlay, J., Ward, E. and Forman, D. (2011) Global Cancer Statistics. CA—A Cancer Journal for Clinicians, 61, 69-90.
[2] Globocan (2008) World Health Organization. International Agency for Research on Cancer.
http://globocan.iarc.fr
[3] Kikuchi, S., Wada, O., Nakajima, T., Nishi, T., Kobayashi, O., Konishi, T. and Inaba, Y. (1995) Serum Anti-Helicobacter Pylori Antibody and Gastric Carcinoma among Young Adults. Research Group on Prevention of Gastric Carcinoma among Young Adults. Cancer, 75, 2789-2793.
http://dx.doi.org/10.1002/1097-0142(19950615)75:12<2789::AID-CNCR2820751202>3.0.CO;2-4
[4] Nomura, A., Stemmermann, G.N., Chyou, P.H., Kato, I., Perez-Perez, G.I. and Blaser, M.J. (1991) Helicobacter pylori Infection and Gastric Carcinoma among Japanese Americans in Hawaii. The New England Journal of Medicine, 325, 1132-1136.
http://dx.doi.org/10.1056/NEJM199110173251604
[5] Weck, M.N., Gao, L. and Brenner, H. (2009) Helicobacter pylori Infection and Chronic Atrophic Gastritis: Associations According to Severity of Disease. Epidemiology, 20, 569-574.
http://dx.doi.org/10.1097/EDE.0b013e3181a3d5f4
[6] Kamath, R., Al-Qamish, J. and Yousif, A. (1995) Prevalence of Helicobacter pylori among Dyspeptic Patients in Bahrain. Bahrain Medical Bulletin, 17, 50-52.
[7] Alazmi, W.M., Siddique, I., Alateeqi, N. and Al-Nakib, B. (2010) Prevalence of Helicobacter pylori Infection among New Outpatients with Dyspepsia in Kuwait. BMC Gastroenterology, 10, 14.
http://dx.doi.org/10.1186/1471-230X-10-14
[8] Leung, W.K., Kim, J.J. and Kim, J.G. (2000) Microsatellite Instability in Gastric Intestinal Metaplasia in Patients with and without Gastric Cancer. The American Journal of Pathology, 156, 537-543.
http://dx.doi.org/10.1016/S0002-9440(10)64758-X
[9] Capella, C., Fiocca, R. and Cornaggia, M. (1999) Autoimmune Gastritis. In: Graham, D.Y., Genta, R.M. and Dixon, M.F., Eds., Gastritis, Lippincott Williams, Philadelphia, 79-96.
[10] Whittingham, S. and Mackay, I.R. (2005) Autoimmune Gastritis: Historical Antecedents, Outstanding Discoveries, and Unresolved Problems. International Reviews of Immunology, 24, 1-29.
http://dx.doi.org/10.1080/08830180590884413
[11] Piessen, G., Messager, M., Leteurtre, E., Jean-Pierre, T. And Mariette, C. (2009) Signet Ring Cell Histology Is an Independent Predictor of Poor Prognosis in Gastric Adenocarcinoma Regardless of Tumoural Clinical Presentation. Annals of Surgery, 250, 878-887.
http://dx.doi.org/10.1097/SLA.0b013e3181b21c7b
[12] Garcia, M., Jemal, A., Ward, E.M., Center, M.M., Hao, Y., Siegel, R.L. and Thun, M.J. (2007) Global Cancer Facts & Figures 2007. American Cancer Society, Atlanta.
https://www.cancer.org/acs/groups/content/@nho/documents/document/globalfactsandfigures2007re v2p.pdf
[13] Eisenberg, B.L. and Trent, J.C. (2011) Adjuvant and Neoadjuvant Imatinib Therapy: Current Role in the Management of Gastrointestinal Stromal Tumours. International Journal of Cancer, 129, 2533-2542.
http://dx.doi.org/10.1002/ijc.26234

  
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