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A Study on the Safety of Liver Biopsy Inpatients with Von Willebrand’s Disease

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DOI: 10.4236/ojgas.2015.59022    3,991 Downloads   4,384 Views  

ABSTRACT

Objectives: Liver biopsy remains the gold standard for diagnosis of chronic liver diseases. Outpatient percutaneous biopsy is generally safe with a mortality rate of 0.17% and hospitalization rate for bleeding of 3%. Von Willebrand disease (vWD) syndrome is the most common inherited hematological disorder with a prevalence of 1% - 3% globally. We sought to study whether vWD increases the risk of bleeding for liver biopsies. Methods: All patients (n = 120) who underwent outpatient percutaneous liver biopsies from 1997 to 2007 were analyzed. Demographics, PT/INR, platelet count, vW antigen and ristocetin induced platelet aggregation were studied. Results: No vWD patients had major bleeding that required transfusion, hospitalization or surgery but 9 (75%) had minor local bleeding and all had ecchymosis, which resolved spontaneously within 24 hours. Conclusions: Patients with vW factor deficiency can undergo percutaneous liver biopsy without major bleeding. Minor bleeding may occur at a slightly higher rate. vWD is not a contraindication to percutaneous liver biopsy.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Basu, P. , Shah, N. , Aloysius, M. , Rayapudi, K. and Brown, R. (2015) A Study on the Safety of Liver Biopsy Inpatients with Von Willebrand’s Disease. Open Journal of Gastroenterology, 5, 134-138. doi: 10.4236/ojgas.2015.59022.

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