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Natural ECM-Bacterial Cellulose Wound Healing—Dubai Study

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DOI: 10.4236/jbnb.2015.64022    4,952 Downloads   5,608 Views   Citations

ABSTRACT

Bacterial cellulose (BC) can be used in wide area of applied scientific, especially for tissue regeneration and regenerative medicine, lately, bacterial cellulose mats are used in the treatment of skin conditions such as burns and ulcers, because of the morphology of fibrous biopolymers serving as a support for cell proliferation, its pores allow gas exchange between the organism and the environment. Moreover, the nanostructure and morphological similarities with collagen make BC attractive for cell immobilization, cell support and Natural Extracellular Matrix (ECM) Scaffolds. In this scope, Natural ECM is the ideal biological scaffold since it contains all the components of the tissue. The development of mimicking biomaterials and hybrid biomaterial can further advance directed cellular differentiation without specific induction. The extracellular matrix (ECM) contains several signals that are received by cell surface receptors and contribute to cell adhesion and cell fate which control cellular activities such as proliferation, migration and differentiation. As such, regenerative medicine studies often rely on mimicking the natural ECM to promote the formation of new tissue by host cells, and characterization of natural ECM components is vital for the development of new biomimetic approaches. In this work, the bacterial cellulose fermentation process is modified by the addition of vegetal stem cell to the culture medium and natural materials before the bacteria are inoculated. In vivo behavior using natural ECM for regenerative medicine is presented.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

El-Hoseny, S. , Basmaji, P. , Olyveira, G. , Costa, L. , Alwahedi, A. , Oliveira, J. and Francozo, G. (2015) Natural ECM-Bacterial Cellulose Wound Healing—Dubai Study. Journal of Biomaterials and Nanobiotechnology, 6, 237-246. doi: 10.4236/jbnb.2015.64022.

References

[1] Canavan, R., Connolly, V., Mcintosh, J., Airey, M. and Unwin, N. (2003) Geographic Variation in Lower Extremity Amputation Rates. Diabetic Foot, 6, 82-89.
[2] Vowden, K.R. and Vowden, P. (1996) Peripheral Arterial Disease. Journal of Wound Care, 5, 23-26.
[3] Van Gent,W.B., Wilschut, E.D. and Wittens, C. (2010) Management of Venous Ulcer Disease. BMJ, 341, Article ID: c6045.
http://dx.doi.org/10.1136/bmj.c6045
[4] Rayner, R., Carville, K., Keaton, J., Prentice, J. and Santamaria, X.N. (2009) Leg Ulcers: Atypical Presentations and Associated Comorbidities. Wound Practice and Research, 17, 168-185.
[5] Rahman, G.A., Adigun, I.A. and Fadeyi, A. (2010) Epidemiology, Etiology, and Treatment of Chronic Leg Ulcer: Experience with Sixty Patients. Annals of African Medicine, 9, 1-4.
http://dx.doi.org/10.4103/1596-3519.62615
[6] Faria, E., Blanes, L., Hochman, B., Filho, M.M. and Ferreira, L. (2011) Health-Related Quality of Life, Self-Esteem, and Functional Status of Patients with Leg Ulcers. Wounds, 23, 4-10.
[7] Siddiqui, A.R. and Bernstein, J.M. (2010) Chronic Wound Infection: Facts and Controversies. Clinics in Dermatology, 28, 519-526.
http://dx.doi.org/10.1016/j.clindermatol.2010.03.009
[8] Han, A., Zenilman, J.M., Melendez, J.H., Shirtliff, M.E., Agostinho, A., James, G., Stewart, P.S., Mongodin, E.F., Rao, D., Rickard, A.H. and Lazarus, G.S. (2011) The Importance of a Multi-Faceted Approach to Characterizing the Microbial Flora of Chronic Wounds. Wound Repair and Regeneration, 19, 532-541.
http://dx.doi.org/10.1111/j.1524-475X.2011.00720.x
[9] Costa, L.M.M., Olyveira, G.M., Basmaji, P., Valido, D.P., Góis, P.B.P., Júnior, R.L.A.C. and Filho, L.X. (2012) Novel Otoliths/Bacterial Cellulose Nanocomposites as a Potential Natural Product for Direct Dental Pulp Capping. Journal of Biomaterials and Tissue Engineering, 2, 48-53.
http://dx.doi.org/10.1166/jbt.2012.1031
[10] Olyveira, G.M., Santos, M.L., Riccardi, C.S., Costa, L.M.M., Daltro, P.B., Basmaji, P., Daltro, G.C. and Guastaldi, A.C. (2015) Bacterial Cellulose Biocomposites for Periodontology Treatment. Advanced Science, Engineering and Medicine, 6, 1-6.
http://dx.doi.org/10.1166/asem.2015.1641
[11] Costa, L.M.M., Olyveira, G.M., Basmaji, P. and Filho, L.X. (2011) Bacterial Cellulose towards Functional Green Composites Materials. Journal of Bionanoscience, 5, 167-172.
http://dx.doi.org/10.1166/jbns.2011.1060
[12] Costa, L.M.M., Olyveira, G.M., Basmaji, P. and Filho, L.X. (2012) Bacterial Cellulose towards Functional Medical Materials. Journal of Biomaterials and Tissue Engineering, 2, 185-196.
http://dx.doi.org/10.1166/jbt.2012.1044
[13] Olyveira, G.M., Costa, L.M.M. and Basmaji, P. (2013) Physically Modified Bacterial Cellulose as Alternative Routes for Transdermal Drug Delivery. Journal of Biomaterials and Tissue Engineering, 2, 1-6.
[14] Olyveira, G.M., Riccardi, C.S., Santos, M.L., Costa, L.M.M., Daltro, P.B., Basmaji, P., Daltro, G.C. and Guastaldi, A.C. (2014) Bacterial Cellulose Nanobiocomposites for Periodontal Disease. Journal of Bionanoscience, 8, 319, 324.
http://dx.doi.org/10.1166/jbns.2014.1241
[15] Gois, P.B.P., Olyveira, G.M., Costa, L.M.M., Chianca, C.F., Fraga, I.I.S., Basmaji, P., Cordoba, C.V. and Filho, L.X. (2013) Influence of Symbioses Culture between Microorganisms/Yeast Strain on Cellulose Synthesis. International Review of Biophysical Chemistry, 3, 48-54.
[16] Filho, L.X., OLyveira, G.M., Costa, L.M.M. and Basmaji, P. (2013) Novel Electrospun Nanotholits/PHB Scaffolds for Bone Tissue Regeneration. Journal of Nanoscience and Nanotechnology, 13, 1-5.
http://dx.doi.org/10.1166/jnn.2013.7191
[17] Olyveira, G.M., Costa, L.M.M., Basmaji, P. and Filho, L.X. (2011) Bacterial Nanocellulose for Medicine Regenerative. Journal of Nanotechnology in Engineering and Medicine, 2, 34001-34009.
http://dx.doi.org/10.1115/1.4004181
[18] Olyveira, G.M., Santos, M.L., Daltro, P.B., Basmaji, P., Daltro, G.C. and Guastaldi, A.C. (2014) Bacterial Cellulose/Chondroitin Sulfate for Dental Materials Scaffolds. Journal of Biomaterials and Tissue Engineering, 4, 1-5.
http://dx.doi.org/10.1166/jbt.2014.1155
[19] Olyveira, G.M., Santos, M.L., Costa, L.M.M., Daltro, P.B., Basmaji, P., Daltro, G.C. and Guastaldi, A.C. (2014) Bacterial Cellulose Nanobiocomposites for Dental Materials Scaffolds. Journal of Biomaterials and Tissue Engineering, 4, 536-542.
http://dx.doi.org/10.1166/jbt.2014.1202
[20] Olyveira, G.M., Santos, M.L., Costa, L.M.M., Daltro, P.B., Basmaji, P., Daltro, G.C. and Guastaldi, A.C. (2014) Bacterial Biocomposites for Guided Tissue Regeneration. Science of Advanced Materials, 6, 1-6.
http://dx.doi.org/10.1166/sam.2014.1985
[21] Olyveira, G.M., Santos, M.L., Costa, L.M.M., Daltro, P.B., Basmaji, P., Daltro, G.C. and Guastaldi, A.C. (2015) Physically Modified Bacterial Cellulose Biocomposites for Guided Tissue Regeneration. Science of Advanced Materials, 7, 1-8.
[22] Olyveira, G.M., Santos, M.L., Costa, L.M.M., Riccardi, C.S., Daltro, P.B., Basmaji, P., Daltro, G.C. and Guastaldi, A.C. (2015) Physically Modified Bacterial Cellulose Biocomposites for Dental Materials Scaffolds. Materials Focus, 4, 1-7.
http://dx.doi.org/10.1166/mat.2015.1224
[23] Olyveira, G.M., Acasigua, G.A.X., Costa, L.M.M., Scher, C.R., Filho, L.X., Pranke, P.H.L. and Basmaji, P. (2013) Human Dental Pulp Stem Cell Behavior Using Natural Nanotolith/Bacterial Cellulose Scaffolds for Regenerative Medicine. Journal of Biomedical Nanotechnology, 9, 1-8.
http://dx.doi.org/10.1166/jbn.2013.1620
[24] Acasigua, G.A.X.m Olyveira, G.M., Costa, L.M.M., Braghirolli, D.A., Guastaldi, A.C., Pranke, P. and Basmaji, P. (2014) Novel Natural Bacterial Cellulose Nanocomposites as Potential Biomaterial for Stem Cell Therapy. Current Stem Cell Research and Therapy, 9, 117-123.
http://dx.doi.org/10.2174/1574888X08666131124135654
[25] Salmen, L., Akerholm, M. and Hinterstoisser, B. (2005) Two-Dimensional Fourier Transform Infrared Spectroscopy Applied to Cellulose and Paper. In: Dumitriu, S., Ed., Polysaccharides: Structural Diversity and Functional Versatility, 2nd Edition, Marcel Dekker, New York, 159-187.
[26] Kondo, T. (1998) Hydrogen Bonds in Cellulose and Cellulose Derivatives. In: Dumitriu, S., Ed., Polysaccharides: Structural Diversity and Functional Versatility, Marcel Dekker, Inc., New York, 131-172.

  
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