Share This Article:

Management of HIV in Children Using a Bovine Colostrum-Based Food Product— An Observational Field Study

Abstract Full-Text HTML XML Download Download as PDF (Size:242KB) PP. 100-104
DOI: 10.4236/wja.2015.52012    1,790 Downloads   2,214 Views   Citations

ABSTRACT

Aim: Malnutrition increases the severity and mortality of HIV infection. Therefore, this field study was started and aimed to provide a major cohort of HIV-infected children with the colostrum-based food product ColoPlus (ColoPlus AB, Malmö, Sweden) and to investigate the effects of ColoPlus on the nutritional status and immunological capacity of children including tolerability and safety of the product. Methods: In this major field program comprising 850 malnourished HIV positive children, 50 grams of ColoPlus was administrated for 4 weeks as the first meal in selected health facilities in Northern Uganda. Forty-eight of these children (8 months - 14 years of age) were recruited into a descriptive prospective study and were followed for 12 weeks. At the start (week 0) and at weeks 4, 8 and 12, CD4+ cell counts, serum albumin and hemoglobin were analyzed. The remaining 802 patients were observed to register safety and tolerability of ColoPlus. Results: There was a general improvement of wellbeing of the children with increased body weight and decreased fatigue. In the descriptive study of the 48 children, there was a significant rise of the CD4+ values at week 4 (+15.4% ± 2.8%, p = 0.0001) compared to week 0, and at week 8 (+39.1% ± 3.9%, p < 0.0001), but a return towards the 0-values at week 12 (+2.1%, ±2.8%, NS). Hemoglobin and serum albumin showed an almost similar trend. ColoPlus was well tolerated by all the 850 children and no side effects or adverse events were seen. Conclusion: These results show that addition of a colostrum-based food product to the daily diet is beneficial in HIV-positive malnourished children. An improvement in nutritional status as well as in immune capacity was seen. These effects were prolonged and remained at least 4 weeks after cessation of ColoPlus administration.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Odong, P. , Angwech, P. , Obol, J. and Florén, C. (2015) Management of HIV in Children Using a Bovine Colostrum-Based Food Product— An Observational Field Study. World Journal of AIDS, 5, 100-104. doi: 10.4236/wja.2015.52012.

References

[1] Rump, J.A., Arndt, A.A., et al. (1992) Treatment of Diarrhea in Human Immunodeficiency Virus-Infected Patients with Immunoglobulins from Bovine Colostrums. Clinical Investigation, 70, 588-594.
http://dx.doi.org/10.1007/BF00184800
[2] Pakkanen, R. and Aalto, J. (1997) Growth Factors and Antimicrobial Factors of Bovine Colostrums. International Dairy Journal, 7, 285-297. http://dx.doi.org/10.1016/S0958-6946(97)00022-8
[3] Plattenberg, A., Stoehr, A., Stellbrink, H.J., Albrecht, H. and Meigel, W. (1993) A Preparation from Bovine Colostrum in the Treatment of HIV-Positive Patients with Chronic Diarrhea. Clinical Invest-igation, 71, 42-45. http://dx.doi.org/10.1007/BF00210962
[4] Greenberg, P.D. and Cello, J.P. (1996) Treatment of Severe Diarrhea Caused by Cryptosporidium parvum with Oral Bovine Immunoglobulin Concentrate in Patients with AIDS. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 13, 348-354.
http://dx.doi.org/10.1097/00042560-199612010-00008
[5] Nord, J., Ma, P., Di John, D., Tzipori, S. and Tacket, C.O. (1990) Treatment with Bovine Hyperimmune Colostrum of Cryptosporidial Diarrhea in AIDS Patients. AIDS, 4, 581-584.
http://dx.doi.org/10.1097/00002030-199006000-00015
[6] Beth, L., Ungar, P. and Douglas, J. (1990) Cessation of Cryptosporidium Associated Diarrhea in Acquired Immunodeficiency Syndrome Patient after Treatment with Hyperimmune Bovine Colostrum. Gastroenterology, 98, 486-489.
[7] Floren, C.-H., Chinenye, S., Elfstrand, L., Hagman, C. and Ihse, I. (2006) ColoPlus, a New Product Based on Bovine Colostrum, Alleviates HIV-Associated Diarrhea. Scandinavian Journal of Gastro-enterology, 41, 682-686. http://dx.doi.org/10.1080/00365520500380817
[8] Kaducu, F.O., Okia, S.A., Upenytho, G., Elfstrand, L. and Floren, C.-H. (2011) Effects of Bovine Colostrum-Based Food Supplement in the Treatment of HIV-Associated Diarrhea in Uganda. Indian Journal of Gastroenterology, 30, 270-276. http://dx.doi.org/10.1007/s12664-011-0146-0
[9] Elfstrand, L. and Floren, C.-H. (2010) Management of Chronic Diarrhea in HIV-Infected Patients: Current Treatment Options, Challenges and Future Directions. HIV/AIDS-Research and Palliative Care, 2, 219-224.
[10] Paton, N.I., Sangeetha, S., Earnest, A. and Bellamy, R. (2006) The Impact of Malnutrition on Survival and the CD4 Count Response in HIV-Infected Patients Starting Antiretroviral Therapy. HIV Medication, 7, 323-330.
[11] Byakwaga, H., Kelly, M., Purcell, D.F., French, M.A., Amin, J., Lewin, S.R., Haskelberg, H., Kelleher, A.D., Garsia, R., Boyd, M.A., Cooper, D.A. and Emery, S. (2011) Coral Study Group. Antiretroviral Therapy Intensification with Raltegravir and/or Hyperimmune Bovine Colostrum in HIV-1 Infected Patients with Suboptimal CD4+ T Cell Response: A Randomized Controlled Trial. Journal of Infectious Diseases, 204, 1532-1540. http://dx.doi.org/10.1093/infdis/jir559

  
comments powered by Disqus

Copyright © 2018 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.