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Structural Factors of Annonaceous Acetogenins and Their Semisynthetic Analogues Related with the Toxicity on Spodoptera frugiperda

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DOI: 10.4236/jacen.2015.42006    3,285 Downloads   3,757 Views   Citations

ABSTRACT

Toxic and nutritional effects of annonaceous acetogenins and their semisynthetic analogues on Spodoptera frugiperda were evaluated. Structural modification of the natural ACG, blocking the OH flanking THF with MOM, allowed us to suggest the mode of action of ACG in the membrane. Our study emphasizes the role of the flanking OH and acetyl groups of THF with the membrane hydrophilic polar head groups. They are essential structural factors in the ACG that facilitate the intermolecular interaction that dehydrates the membrane and makes it potentially toxic against Spodoptera frugiperda.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Di Toto Blessing, L. , Budeguer, F. , Ramos, J. , Bardón, A. , Diaz, S. , Brovetto, M. , Seoane, G. and Neske, A. (2015) Structural Factors of Annonaceous Acetogenins and Their Semisynthetic Analogues Related with the Toxicity on Spodoptera frugiperda. Journal of Agricultural Chemistry and Environment, 4, 56-61. doi: 10.4236/jacen.2015.42006.

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