Share This Article:

Association between Hepato-Biliary Status and HbA1C in Type 2 Diabetes Mellitus with Coronary Artery Disease (CAD)

Abstract Full-Text HTML XML Download Download as PDF (Size:236KB) PP. 67-71
DOI: 10.4236/jdm.2015.52008    2,578 Downloads   3,023 Views   Citations

ABSTRACT

Bilirubin has both antioxidant activity and cardioprotective potential. Decreased levels are associated with predicting CAD. Recent studies showed that bilirubin has inverse correlation with glycemic status. So in this we evaluated the role of Hepatobiliary function as a marker of predictor CAD in patient with T2DM. Total 100 subjects included 50 T2DM patients with CAD and 50 T2DM without CAD. All the subject venous blood was collected after overnight fasting for biochemical analysis. After the statistical analysis, the results showed significant difference between two groups as follows total bilirubin (0.32 ± 0.15; 0.90 ± 032; p = 0.000), direct bilirubin, indirect bilirubibn, Total Protein, Albumin, ALT, AST, HbA1c. Our finding implies that decreased serum bilirubin increases the risk of CAD in patients with T2DM and it shows inverse correlation between HbA1c and bilirubin.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Ramesh, R. , AdhishwarKumaran, N. , KuzhandaiVelu, V. , Reeta, R. , SathishBabu, M. and Niranjan, G. (2015) Association between Hepato-Biliary Status and HbA1C in Type 2 Diabetes Mellitus with Coronary Artery Disease (CAD). Journal of Diabetes Mellitus, 5, 67-71. doi: 10.4236/jdm.2015.52008.

References

[1] Treeprasertsuk, S., Lopez-Jimenez, F. and Lindor, K.D. (2011) Nonalcoholic Fatty Liver Disease and the Coronary Artery Disease. Digestive Diseases and Sciences, 56, 35-45.
http://dx.doi.org/10.1007/s10620-010-1241-2
[2] Kotronen, A., Juurinen, L., Tiikkainen, M., Vehkavaara, S. and Yki-Järvinen, H. (2008) Increased Liver Fat, Impaired Insulin Clearance, and Hepatic and Adipose Tissue Insulin Resistance in Type 2 Diabetes. Gastroenterology, 135, 122-130. http://dx.doi.org/10.1053/j.gastro.2008.03.021
[3] Edmison, J. and McCullough, A.J. (2007) Pathogenesis of Non-Alcoholic Steatohepatitis: Human Data. Clinics in Liver Disease, 11, 75-104. http://dx.doi.org/10.1016/j.cld.2007.02.011
[4] Treeprasertsuk, S., Leverage, S., Adams, L.A., Lindor, K.D., St. Sauver, J. and Angulo, P. (2012) The Framingham Risk Score and Heart Disease in Nonalcoholic Fatty Liver Disease. Liver International, 32, 945-950. http://dx.doi.org/10.1111/j.1478-3231.2011.02753.x
[5] Kuzhandai velu, V., Jyothirmayi, B. and Kumar, J.S. (2011) Insulin Resistance and Alanine Amino Transaminase (ALT) Levels in First Degree Relatives of Type 2 Diabetes Mellitus. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 5, 143-147. http://dx.doi.org/10.1016/j.dsx.2012.02.011
[6] Gopal, N., Selvam, A. and Muddegowda, P.H. (2012) Serum Gamma Glutamyl Transferase levels in Obese South Indian Adults with Reference to Atherogenic Lipid Risk Factors and Lipid Peroxides. International Journal of Medical and Health Sciences, 1, 35-42.
[7] Majhi, S., Baral, N., Lamsal, M. and Mehta, K.D. (2006) De Ritis Ratio as Diagnostic Marker of Alcoholic Liver Disease. Nepal Medical College Journal, 8, 40-42.
[8] Arthi, M., Niranjan, G., Hanifah, M. and Srinivasan, A.R. (2011) Efficacy of De Ritis Ration in Diagnosing Liver Diseases in Puducherry Population. Advance Laboratory Medicine International, 1, 61-68.
[9] Mayer, M. (2000) Association of Serum Bilirubin Concentration with Risk of Coronary Artery Disease. Clinical Chemistry, 46, 1723-1727.
[10] Arumalla, V.K., Gopal, N. and Bn, R. (2012) Role of Serum Bilirubin in Coronary Artery Disease. International Journal of Medical and Health Sciences, 1, 56-62.
[11] Cersosimo, E. and DeFronzo, R.A. (2006) Insulin Resistance and Endothelial Dysfunction: The Road Map to Cardiovascular Diseases. Diabetes/Metabolism Research and Reviews, 22, 423-436.
http://dx.doi.org/10.1002/dmrr.634
[12] Schwertner, H.A., Jackson, W.G. and Tolan, G. (1994) Association of Low Serum Concentration of Bilirubin with Increased Risk of Coronary Artery Disease. Clinical Chemistry, 40, 18-23.
[13] Hopkins, P.N., Wu, L.L., Hunt, S.C., James, B.C., Vincent, G.M. and Williams, R.R. (1996) Higher Serum Bilirubin Is Associated with Decreased Risk for Early Familial Coronary Artery Disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 16, 250-255.
http://dx.doi.org/10.1161/01.ATV.16.2.250
[14] Perlstein, T.S., Pande, R.L., Beckman, J.A. and Creager, M.A. (2008) Serum Total Bilirubin Level and Prevalent Lower-Extremity Peripheral Arterial Disease: National Health and Nutrition Examination Survey (NHANES) 1999 to 2004. Arteriosclerosis, Thrombosis, and Vascular Biology, 28, 166-172. http://dx.doi.org/10.1161/ATVBAHA.107.153262
[15] Stocker, R., Yamamoto, Y., McDonagh, A.F., Glazer, A.N. and Ames, B.N. (1987) Bilirubin Is an Antioxidant of Possible Physiological Importance. Science, 235, 1043-1046.
http://dx.doi.org/10.1126/science.3029864
[16] Kawamoto, R., Kohara, K., Kusunoki, T., Tabara, Y., Abe, M. and Miki, T. (2012) Alanine Aminotransferase/Aspartate Aminotransferase Ratio Is the Best Surrogate Marker for Insulin Resistance in Non-Obese Japanese Adults. Cardiovascular Diabetology, 11, 117.
http://dx.doi.org/10.1186/1475-2840-11-117
[17] Balkau, B. and Eschwège, E. (1999) Insulin Resistance: An Independent Risk Factor for Cardiovascular Disease? Diabetes, Obesity and Metabolism, 1, S23-S31.
http://dx.doi.org/10.1046/j.1463-1326.1999.0010s1023.x
[18] Misra, V.L., Khashab, M. and Chalasani, N. (2009) Non-Alcoholic Fatty Liver Disease and Cardiovascular Risk. Current Gastroenterology Reports, 11, 50-55.
http://dx.doi.org/10.1007/s11894-009-0008-4
[19] Hamaguchi, M., Kojima, T., Takeda, N., Nagata, C., Takeda, J., Sarui, H., Kawahito, Y., Yoshida, N., Suetsugu, A., Kato, T., Okuda, J., Ida, K. and Yoshikawa, T. (2007) Nonalcoholic Fatty Liver Disease Is a Novel Predictor of Cardiovascular Disease. World Journal of Gastroenterology, 13, 1579-1584. http://dx.doi.org/10.3748/wjg.v13.i10.1579
[20] Oda, E. and Kawai, R. (2011) Bilirubin Is Negatively Associated With Hemoglobin A1c Independently of Other Cardiovascular Risk Factors in Apparently Healthy Japanese Men and Women. Circulation Journal, 75, 190-195.http://dx.doi.org/10.1253/circj.CJ-10-0645

  
comments powered by Disqus

Copyright © 2019 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.