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Antidepressant-Like Effect of Tetramethylpyrazine in Mice and Rats

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DOI: 10.4236/nm.2011.22020    4,589 Downloads   8,815 Views   Citations

ABSTRACT

The aim of this study was to investigate the potential antidepressive-like effect of tetramethylpyrazine (TMP), one of available blood-activating and stasis-eliminating components from traditional Chinese medicines, and its mechanism of the antidepressant-like action. Forced-swimming, tail-suspension, reserpine-induced hypothermia, akinesia and ptosis, 5-hydroxytryptophan (5-HTP)-induced head-twitch, and potentiation of noradrenaline (NE) toxicity tests, were per-formed to assess the potential antidepressant-like activity of TMP and to study the mechanism by which TMP exerts the antidepressant-like action. Intragastric (ig) administration of TMP markedly reduced the duration of immobility during forced-swimming tests and tail-supension test in rats and mice. TMP partialy reversed reserpine-induced hypothermia, ptosis and akinesia, and potentiated NE toxicity in mice, and these are similar to those of clomipramine; however, TMP did not potentiate 5-HTP-induced head-twitch response (HTR) in mice, and this is different from that of fluoxetine (FLU). The present data provide evidences that TMP possesses potent antidepressant-like activity, and it might be an adrenergic component of pharmacological activity, and its mechanism of antidepressant-like action is similar to that of clomipramine, and different from that of FLU.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

L. Yu, X. Jiang, M. Liao, R. Ma and T. Yu, "Antidepressant-Like Effect of Tetramethylpyrazine in Mice and Rats," Neuroscience and Medicine, Vol. 2 No. 2, 2011, pp. 142-148. doi: 10.4236/nm.2011.22020.

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