Share This Article:

Why Ben-Naim’s Deepest Pitfall Does Not Exist

Abstract Full-Text HTML XML Download Download as PDF (Size:229KB) PP. 45-49
DOI: 10.4236/ojbiphy.2015.52004    3,811 Downloads   4,221 Views   Citations
Author(s)    Leave a comment

ABSTRACT

Ben-Naim warns that there are pitfalls in pursuing Anfinsen’s thermodynamic hypothesis. We show that the deepest one of his pitfalls is not a pitfall at all and the believing pursuing the minimum of the Gibbs free energy will lead us to the native structure. The “pitfall” came from the flawed inference of Gibbs energy function and the muddiness on concepts such as thermodynamic system and the second law of thermodynamics.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Fang, Y. (2015) Why Ben-Naim’s Deepest Pitfall Does Not Exist. Open Journal of Biophysics, 5, 45-49. doi: 10.4236/ojbiphy.2015.52004.

References

[1] Ben-Naim, A. (2011) Pitfalls in Anfinsen’s Thermodynamic Hypothesis. Chemical Physics Letters, 511, 126-128.
http://dx.doi.org/10.1016/j.cplett.2011.05.049
[2] Anfinsen, C.B. (1973) Principles That Govern the Folding of Protein Chains. Science, 181, 223-230.
http://dx.doi.org/10.1126/science.181.4096.223
[3] Ben-Naim, A. (2012) Levinthal’s Question Revisited, and Answered. Journal of Biomolecular Structure and Dynamics, 30, 113-124.
http://dx.doi.org/10.1080/07391102.2012.674286
[4] Ben-Naim, A. (2013) Comment on a Paper: “Ben-Naim’s ‘pitfalls’: Don Quixote’s windmill”, by Y. Fang, Open Journal of Biophysics, 2013, 3, 13-212. Open Journal of Biophysics, 3, 275-276.
http://dx.doi.org/10.4236/ojbiphy.2013.34032
[5] Fang, Y. (2012) Gibbs Free Energy Formula for Protein Folding. In: Morales-Rodriguez, R., Ed., Thermodynamics Fundamentals and Its Application in Science, InTech, 47-82.
http://www.intechopen.com/books/thermodynamics-fundamentals-
and-its-application-in-science
http://dx.doi.org/10.5772/2615
[6] Fang, Y. (2013) Ben-Naim’s “Pitfalls”: Don Quixote’s Windnmill. Open Journal of Biophysics, 3, 13-21.
http://dx.doi.org/10.4236/ojbiphy.2013.31002
[7] Fang, Y. (2014) The Second Law, Gibbs Free Energy, Geometry, and Protein Folding. Journal of Advances in Physics, 3, 278-285.
[8] Fang, Y. (2014) A Gibbs Free Energy Formula for Protein Folding Derived from Quantum Statistics. Science China, Pysics, Mechanics & Astronomy, 57, 1547-1551.
http://dx.doi.org/10.1007/s11433-013-5288-x

  
comments powered by Disqus

Copyright © 2019 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.