Share This Article:

Preparation and Characterization of Holmium-Beta-Cyclodextrin Complex

Abstract Full-Text HTML XML Download Download as PDF (Size:1796KB) PP. 87-94
DOI: 10.4236/ampc.2015.53011    3,329 Downloads   3,796 Views   Citations

ABSTRACT

The purpose of this study was to prepare and characterize of holmium-beta-cyclodextrin complex (Ho-β-CD) in order to increase the solubility and stability of Holmium. To achieve this goal, Ho-β-CD complex was prepared by evaporation method of holmium and beta cyclodextrin solutions in a proportion (1:1) and (1:3), respectively. Infrared (IR) and Raman spectroscopy, X-Ray Diffraction were performed to identify the complex. Morphology of the Ho, β-CD, and Ho-β-CD were studied using Scanning Electron Microscopy (SEM).

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Rojas-Mena, A. , López-González, H. and Rojas-Hernández, A. (2015) Preparation and Characterization of Holmium-Beta-Cyclodextrin Complex. Advances in Materials Physics and Chemistry, 5, 87-94. doi: 10.4236/ampc.2015.53011.

References

[1] Abdelrahman, A.I. (2011) Lanthanide-Encoded Polystyrene Microspheres for Mass Cytometry-Based Bioassays. Thesis, Department of Chemistry, University of Toronto, Toronto.
[2] Zielhuis, S. (2006) Radioactive Particles for Cancer Therapy and Multimodality Imaging. Thesis, University Medical Center Utrecht, Utrecht.
[3] Baran, E.J. (2007) La Nueva Farmacoterapia Inorgánica. XVIII. Compuestos de Lantánidos. Latin American Journal of Pharmacy, 26, 626-634.
[4] Lyra, M., Andreou, M., Georgantzoglou, A., Kardolaimi, S., Lagopati, N., Ploussi, A. and Salvara, A.L. (2011) Ionnis Vamvakas. Nuclear Medicine Therapy. Radiositopes Production and Dosimetry, 2-6.
[5] IAEA-TECDOC-1228 (2011) Herapeutic Applications of Radiopharmaceuticals. Proceedings of an International Seminar, Hyderabad, 18-22 January 1999, 1-6.
[6] Lira, R.A., Myamoto, D.M., Souza, J.R., Nascimento, N., Osso Junior, J.A., Martinelli, J.R. and de Burgos M. de Azevedo, M. (2011) Microspheres with an Ultra-High Holmium Content for Brachytherapy of Malignancies. 2011 International Nuclear Atalntic Conference-INAC 2011, Belo Horizonte, 24-28 October 2011, 12 p.
[7] Yavari, K., Hadi, K., Mohamad, T., Mazidi, M., Bagher, K., Asl, R.S. and Maragheh, M.G. (2013) Development of 166Ho Poly Lactic Acid Microspheres for Radiosynovectomy. Journal of Pharamacy and Pharmacolgy, 1, 25-35.
[8] de Lacerda, S.M.V. (2009) Copper, Samarium and Holmium Complexes with Tetraazamacrocycles Potencially Interesting for Nuclear Medicine. Thesis, Departamento de Química e Bioquímica, Faculdad de Ciencias, Universidade de Lisboa, Loures.
[9] Loftsson, T. and Brewster, M.E. (1996) Pharmaceutical Applications of Cycldextrins. 1. Drug Solubilization and Stabilization. Journal of Pharamceutical Science, 85, 1017-1025.
http://dx.doi.org/10.1021/js950534b
[10] Moscoso, D.A. (2010) Multifunctional Platforms Based on Cyclodextrins: Design Antitoxins of Anthrax and Gene Vectors. PhD Thesis, Institute of Chemical Research of the Higher Council for Scientific Research, Department of Chemistry, University of Sevilla, Sevilla.
[11] Prakash Rao, B., Sarasija, S., Narendra, C. and Balasangameshwer (2006) Physicochemical Characterization of β-Cyclodextrin and Hydroxy Ethyl β-Cyclodextrin Complexes of Rifampicin. ARS Pharmaceutica, 47, 37-59.
[12] Martinez, G. and Gamez, M.A. (2007) Cyclodextrins: Inclusion Complexes with Polymers. Revista Iberoamericana de Polymers, 8, 300-312.
[13] Restrepo, J., Vinasco, L.E., Jaramillo, L.P. and Colmenares, A.J. (2009) Encapsulation of Essential Oils Citral (Cymbopogon citratus) in β-Cyclodextrins Using Supercritical CO2. Engineering and Competitiveness Magazine, 11, 9-19.
[14] Sambasevam, K.P., Mohamad, S., Sarih, N.M. and Ismail, N.A. (2013) Synthesis and Characterization of the Inclusion Complex of β-Cyclodextrin and Azomethine. International Journal of Molecular Sciences, 14, 3671-3682.
http://dx.doi.org/10.3390/ijms14023671
[15] Wang, H.Y., Han, J. and Xia, G.F. (2007) Spectroscopy Study of Orange G-β-Cyclodextrin Complex and Its Analytical Application. Spectrochimica Acta Part A: Molecular and Biomolecular, 66, 578-585.
http://dx.doi.org/10.1016/j.saa.2006.03.035
[16] Balboul, B.A.A.A. (2000) Physicochemical Characterization of the Decomposition Course of Hydrated Holmium Nitrate. Thermoanalytical Studies. Powder Technology, 107, 168-174.
http://dx.doi.org/10.1016/S0032-5910(99)00183-7
[17] Maixner, J. and Bartunek, V. (2012) X-Ray Powder Diffraction Data for Holmium Nitrate Pentahydrate. Powder Diffraction Pattern, 27, 203-207.

  
comments powered by Disqus

Copyright © 2018 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.