Share This Article:

A New Early Gastric Cancer after Subtotal Gastric Resection for Early Cancer: Case Report and Review of the Literature

Abstract Full-Text HTML XML Download Download as PDF (Size:2466KB) PP. 1450-1453
DOI: 10.4236/jct.2014.514146    3,139 Downloads   3,513 Views  

ABSTRACT

Although the prognosis of early gastric cancer (EGC) is considered to be satisfactory, some patients experience tumor relapse after curative surgery. Both pathogenesis and risk factors of recurrence remain unclear. We describe a case report of a 49-year-old male who underwent subtotal gastric resection D2A for angular gastric cancer. Histological examination revealed gastric adenocarcinoma with low grade of differentiation and colloid areas, intramucosal, and absence of neoplastic proliferation in the surgical margins, in omental stroma and in the six examined lymph nodes (pT1, pN0). 11 years later, the same patient underwent D2 total gastrectomy for gastric cancer in the remnant stomach. New histological examination revealed again gastric adenocarcinoma, intramucosal, medium degree of differentiation, no documentable neoplastic proliferation within the limits of surgical resection, in the thirty-three examined lymph nodes and in the omentum (pT1, pN0).

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Bruno, L. , Barni, L. , Nesi, G. , Pacciani, S. , Masini, G. , Melli, F. , Maltinti, G. , Zalla, T. , Dioscoridi, L. , Taddei, A. , Freschi, G. and Bechi, P. (2014) A New Early Gastric Cancer after Subtotal Gastric Resection for Early Cancer: Case Report and Review of the Literature. Journal of Cancer Therapy, 5, 1450-1453. doi: 10.4236/jct.2014.514146.

References

[1] Japanese Gastric Cancer Association (1998) Japanese Classification of Gastric Carcinoma. 2nd English Edition. Gastric Cancer, 1, 10-24. http://dx.doi.org/10.1007/PL00011681
[2] Degiuli, M. and Calvo, F. (2006) Survival of Early Gastric Cancer in a Specialized European Center. Which Lymphadenectomy Is Necessary? World Journal of Surgery, 30, 2193-2203.
http://dx.doi.org/10.1007/s00268-006-0179-1
[3] Borie, F., et al. (2004) Prognostic Factors for Early Gastric Cancer in France: Cox Regression Analysis of 332 Cases. World Journal of Surgery, 28, 686-691. http://dx.doi.org/10.1007/s00268-004-7127-8
[4] Huang, B., et al. (2011) Long-Term Survival Results and Prognostic Factors of Early Gastric Cancer. Experimental and Therapeutic Medicine, 2, 1059-1064.
[5] Roviello, F., et al. (2006) Number of Lymph Node Metastases and Its Prognostic Significance in Early Gastric Cancer: A Multicenter Italian Study. Journal of Surgical Oncology, 94, 275-280.
http://dx.doi.org/10.1002/jso.20566
[6] Lee, H.J., et al. (2003) Clinicopathological Analysis for Recurrence of Early Gastric Cancer. Japanese Journal of Clinical Oncology, 33, 209-214. http://dx.doi.org/10.1093/jjco/hyg042
[7] Nozaki, I., et al. (2010) Risk Factors for Metachronous Gastric Cancer in the Remnant Stomach after Early Cancer Surgery. World Journal of Surgery, 34, 1548-1554. http://dx.doi.org/10.1007/s00268-010-0518-0
[8] Oliveira, C., et al. (2013) E-Cadherin Alterations in Hereditary Disorders with Emphasis on Hereditary Diffuse Gastric Cancer. Progress in Molecular Biology and Translational Science, 116, 337-359.
http://dx.doi.org/10.1016/B978-0-12-394311-8.00015-7
[9] Komatsu, S., et al. (2012) Progression of Remnant Gastric Cancer Is Associated with Duration of Follow-Up Following Distal Gastrectomy. World Journal of Gastroenterology, 18, 2832-2836.
http://dx.doi.org/10.3748/wjg.v18.i22.2832
[10] Ikeda, Y., et al. (2005) Effective Follow-Up for Recurrence or a Second Primary Cancer in Patients with Early Gastric Cancer. British Journal of Surgery, 92, 235-239. http://dx.doi.org/10.1002/bjs.4758
[11] Yamamoto, M., Yamanaka, T., Baba, H., Kakeji, Y. and Maehara, Y. (2008) The Postoperative Recurrence and the Occurrence of Second Primary Carcinomas in Patients with Early Gastric Carcinoma. Journal of Surgical Oncology, 97, 231-235. http://dx.doi.org/10.1002/jso.20946
[12] Nasu, J., Doi, T., Endo, H., Nishina, T., Hirasaki, S. and Hyodo, I. (2005) Characteristics of Metachronous Multiple Early Gastric Cancers after Endoscopic Mucosal Resection. Endoscopy, 37, 990-993.
http://dx.doi.org/10.1055/s-2005-870198
[13] Kang, G.H., Kim, C.J., Kim, W.H., Kang, Y.K., Kim, H.O. and Kim, Y.I. (1997) Genetic Evidence for the Multicentric Origin of Synchronous Multiple Gastric Carcinoma. Laboratory Investigation, 76, 407-417.
[14] Ohtani, H., Yashiro, M., Onoda, N., Nishioka, N., Kato, Y., Yamamoto, S., et al. (2000) Synchronous Multiple Primary Gastrointestinal Cancer Exhibits Frequent Microsatellite Instability. International Journal of Cancer, 86, 678-683.
http://dx.doi.org/10.1002/(SICI)1097-0215(20000601)86:5<678::AID-IJC12>3.0.CO;2-O
[15] Ahn, H.S., Kim, J.W., Yoo, M.W., Park, D.J., Lee, H.J., Lee, K.U. and Yang, H.K. (2008) Clinicopathological Features and Surgical Outcomes of Patients with Remnant Gastric Cancer after a Distal Gastrectomy. Annals of Surgical Oncology, 15, 1632-1639. http://dx.doi.org/10.1245/s10434-008-9871-8
[16] Ohashi, M., Katai, H., Fukagawa, T., Gotoda, T., Sano, T. and Sasako, M. (2007) Cancer of the Gastric Stump Following Distal Gastrectomy for Cancer. British Journal of Surgery, 94, 92-95.
http://dx.doi.org/10.1002/bjs.5538
[17] Sinning, C., Schaefer, N., Standop, J., Hirner, A. and Wolff, M. (2007) Gastric Stump Carcinoma—Epidemiology and Current Concepts in Pathogenesis and Treatment. European Journal of Surgical Oncology, 33, 133-139. http://dx.doi.org/10.1016/j.ejso.2006.09.006
[18] Hosokawa, O., Kaizaki, Y., Watanabe, K., Hattori, M., Douden, K., Hayashi, H. and Maeda, S. (2002) Endoscopic Surveillance for Gastric Remnant Cancer after Early Cancer Surgery. Endoscopy, 34, 469-473. http://dx.doi.org/10.1055/s-2002-32007
[19] Lee, S.B., Kim, J.H., Kim, D.H., Jeon, T.Y., Kim, D.H., Kim, G.H. and Park, D.Y. (2010) Clinicopathological Characteristics and Prognosis of Remnant Gastric Cancer. Journal of Gastric Cancer, 10, 219-225.
http://dx.doi.org/10.5230/jgc.2010.10.4.219
[20] Morgagni, P., Gardini, A., Marrelli, D., Vittimberga, G., Marchet, A., de Manzoni, G., et al. (2014) Gastric Stump Carcinoma after Distal Subtotal Gastrectomy for Early Gastric Cancer: Experience of 541 Patients with Long-Term Follow-Up. The American Journal of Surgery, in Press.
http://dx.doi.org/10.1016/j.amjsurg.2014.06.021

  
comments powered by Disqus

Copyright © 2018 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.