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Embryonal Rhabdomyosarcoma of the Uterine Cervix: Two Cases Report and Literature Review

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DOI: 10.4236/ojog.2014.414122    3,195 Downloads   3,743 Views   Citations

ABSTRACT

Introduction: Embryonal rhabdomyosarcoma (RMS) of the uterine cervix is a rare and extremely aggressive malignant entity. However, prognosis seems to be improved with the use of multimodality approach treatment. Cases: We report the cases of 50- and 51-year-old women, presenting with vaginal bleeding and mass. The two patients underwent radical surgery. Histological examination revealed RMS of uterine cervix. Treatment was effective in the first case but despite the chemotherapy, the second patient died two months later. Discussion and Conclusions: The prognosis of the cervical embryonal RMS depends on clinical and histological features. The current treatment protocols are based on trials done on pediatric patients. Studies on embryonal RMS treatment and outcomes are limited in women over forty years. In patients with unfavorable prognosis characteristics, the multimodality approach including surgery, adjuvant chemo and radiotherapy can be effective. Otherwise, surgery alone can effectively be proposed.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Abdeljalil, K. , Asma, B. , Kouira, M. , Faten, H. , Sawssen, M. , Samir, H. , Mohamed, B. , Habib, E. and Hedi, K. (2014) Embryonal Rhabdomyosarcoma of the Uterine Cervix: Two Cases Report and Literature Review. Open Journal of Obstetrics and Gynecology, 4, 868-873. doi: 10.4236/ojog.2014.414122.

References

[1] Young, J.L. and Miller, R.W. (1975) Incidence of Malignant Tumors in US Children. Journal of Pediatrics, 86, 254- 258. http://dx.doi.org/10.1016/S0022-3476(75)80484-7
[2] Maurer, H.M. (1981) The Intergroup Rhabdomyosarcoma Study: Update, Nov. 1978. National Cancer Institute Monograph, 56, 61-68.
[3] Gordon, A.N. and Montag, T.W. (1990) Sarcoma Botryoides of the Cervix: Excision Followed by Adjuvant Chemotherapy for Preservation of Reproductive Function. Gynecologic Oncology, 36, 119-124.
http://dx.doi.org/10.1016/0090-8258(90)90121-Z
[4] Miyamoto, T., Shiozawa, T., Nakamura, T., et al. (2004) Sarcoma Botryoides of the Uterine Cervix in a 46-Year-Old Woman: Case Report and Literature Review. International Journal of Gynecological Pathology, 23, 78-82. http://dx.doi.org/10.1097/01.pgp.0000101147.41312.54
[5] Brand, E.B., Nieberg, J.S. and Hacker, R.K. (1987) Rhabdomyosarcoma of the Uterine Cervix. Sarcoma Botryoides. Cancer, 60, 552-560.
http://dx.doi.org/10.1002/1097-0142(19871001)60:7<1552::AID-CNCR2820600724>3.0.CO;2-W
[6] Vlahos, N.P.M. and Veridiano, R. (1999) Cervical Sarcoma Botryoides. A Case Report. The Journal of Reproductive Medicine, 44, 306-308.
[7] Ober, W.B. (1971) Sarcoma Botryoides of the Cervix Uteri: A Case Report in a 75-Year-Old Woman. Mount Sinai Journal of Medicine, 38, 363-374.
[8] Sanders, M.A., Gordinier, M., Talwalkar, S.S., et al. (2008) Embryonal Rhabdomyosarcoma of the Uterine Cervix in a 41-Year-Old Woman Treated with Radical Hysterectomy and Adjuvant Chemotherapy. Gynecologic Oncology, 111, 561-563. http://dx.doi.org/10.1016/j.ygyno.2008.07.016
[9] Crist, W.M., Anderson, J.R., Meza, J.L., et al. (2001) Intergroup Rhabdomyosarcoma Study-IV: Results for Patients with Nonmetastatic Disease. Journal of Clinical Oncology, 19, 3091-3102.
[10] Dehner, L.P., Jarzembowski, J.A. and Hill, D.A. (2012) Embryonal Rhabdomyosarcoma of the Uterine Cervix: A Report of 14 Cases and a Discussion of Its Unusual Clinicopathological Associations. Modern Pathology, 25, 602-614. http://dx.doi.org/10.1038/modpathol.2011.185
[11] Smrkolj, S., Rakar, S., Mali?, S., et al. (2011) Advanced Embryonal Rhabdomyosarcoma of the Uterine Cervix: A Case Report. European Journal of Gynaecological Oncology, 32, 203-205.
[12] Sultan, I., Qaddoumi, I., Yaser, S., et al. (2009) Comparing Adult and Pediatric Rhabdomyosarcoma in the Surveillance, Epidemiology and End Results Program, 1973 to 2005: An Analysis of 2600 Patients. Journal of Clinical Oncology, 27, 3391-3397. http://dx.doi.org/10.1200/JCO.2008.19.7483
[13] Baiocchi, G., Faloppa, C.C., Osório, C.A., et al. (2011) Embryonal Rhabdomyosarcoma of the Uterine Cervix in a 47-Year-Old Woman. Journal of Obstetrics and Gynaecology Research, 37, 940-946. http://dx.doi.org/10.1111/j.1447-0756.2010.01449.x
[14] Anyiam, D.C.D., Ukah, C.O., Onyiaorah, I.V., et al. (2010) Sarcoma Botyroides of the Cervix in a HIV Positive 45-Year-Old Woman: A Case Report. Nigerian Journal of Clinical Practice, 13, 341-343.
[15] Hilgers, R.D., Malkasian, G.D. and Soule, E.H. (1970) Embryonal Rhabdomyosarcoma (Botryoid Type) of the Vagina: A Clinicopathologic Review. American Journal of Obstetrics and Gynecology, 107, 484-502.
[16] Daya, D.A. and Scully, R.E. (1988) Sarcoma Botryoides of the Uterine Cervix in Young Women: A Clinicopathological Study of 13 Cases. Gynecologic Oncology, 29, 290-304.
http://dx.doi.org/10.1016/0090-8258(88)90228-4
[17] Hays, D.M., Shimada, H., Raney, R.B., et al. (1988) Clinical Staging and Treatment Results in Rhabdomyosarcoma of the Female Genital Tract among Children and Adolescents. Cancer, 9, 1893-1903. http://dx.doi.org/10.1002/1097-0142(19880501)61:9<1893::AID-CNCR2820610929>3.0.CO;2-9
[18] Adams, B.N., Brandt, J.S., Loukeris, K., et al. (2011) Embryonal Rhabdomyosarcoma of the Cervix and Appendiceal Carcinoid Tumor. Obstetrics & Gynecology, 117, 482-484.
http://dx.doi.org/10.1097/AOG.0b013e3182051dd0
[19] Khosla, D., Gupta, R., Srinivasan, R., et al. (2012) Sarcomas of Uterine Cervix: Clinicopathological Features, Treatment and Outcome. International Journal of Gynecological Cancer, 22, 1026-1030. http://dx.doi.org/10.1097/IGC.0b013e31825a97f6
[20] Wieneer, E., Wharam, M., Vietti, T.J., et al. (1995) The Third Intergroup RMS Study. Journal of Clinical Oncology, 13, 610-630.

  
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