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Bilateral Mixed Germ Cell Tumour in an Adolescent Girl with Premature Ovarian Failure

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DOI: 10.4236/ojog.2014.413111    2,569 Downloads   3,108 Views   Citations

ABSTRACT

Germ cell tumours (GCTs) of the ovary are rare, comprising approximately 20% of all ovarian tumors with the malignant variant accounting for less than 5% of all ovarian neoplasms. Malignant mixed germ cell tumours are rarer still with dysgerminoma & yolk sac tumour being the most common components with three component variants being categorised in the rarest of rare varieties. Bilateral dysgerminomas occur in 15% of germ cell neoplasms but rarely present with premature ovarian failure. We present the case of an adolescent girl with a short history of abdominal pain and distension with amenorrhoea for a year. Clinical and radio ogical examination revealed a pelvic/adnexal mass with elevation of tumour markers and she had to undergo a staging laparotomy with bilateral salpingo-oophorectomy. Histopatholgy examination was reported as malignant mixed germ cell tumour of left ovary, predominantly with immature teratoma and minor components of yolk-sac tumour and dysgerminoma and right ovary with dysgerminoma. In view of mixed germ cell disease, she was planned for adjuvant chemotherapy.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Roy, P. , Biswas, B. , Paul, S. , Choudhrie, L. and Jose, R. (2014) Bilateral Mixed Germ Cell Tumour in an Adolescent Girl with Premature Ovarian Failure. Open Journal of Obstetrics and Gynecology, 4, 805-808. doi: 10.4236/ojog.2014.413111.

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