Share This Article:

Cancer and pH—A Prospective

Abstract Full-Text HTML XML Download Download as PDF (Size:2437KB) PP. 69-72
DOI: 10.4236/ojim.2014.43011    5,671 Downloads   6,062 Views   Citations
Author(s)    Leave a comment

ABSTRACT

How can cancer develop in so many different organs in so many different ways, but the outcome is similar enough to all be under the same title—cancer? There are so many causes of cancer—viruses, genetic defects, sunburn, gastroesophageal reflux, smoking, alcohol, radiation, chemicals, etc. The above variable well known etiologies of cancer could all induce a need for repair which involves alkalinizing the cells involved. Thus the commonality for cancers could be a pH change. If true, this could give the field of cancer prevention and therapy new avenues of pursuit.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

J. Carlin, K. (2014) Cancer and pH—A Prospective. Open Journal of Internal Medicine, 4, 69-72. doi: 10.4236/ojim.2014.43011.

References

[1] Velez, J., Hail Jr., N., Konopleva, M., Zeng, Z., Kojima, K., Samudio, I. and Andreeff, M. (2013) Mitochondrial Uncoupling and Reprograming of Intermediary Metabolism in Leukemia Cells. Frontiers in Oncology, 3, 67.
http://dx.doi.org/10.3389/fonc.2013.00067
[2] Arieff, A., Park, R., Leach, W. and Lazarowitz, V. (1980) Pathophysiology of Experimental Lactic Acidosis in Dogs. American Journal of Physiology, 239, F135-F142.
[3] Lowenstein, J.M. and Chance, B. (1968) The Effect of Hydrogen Ions on the Control of Mitochondrial Respiration. The Journal of Biological Chemistry, 243, 3940-3946.
[4] Madshus, I.H. (1988) Regulation of Intracellular pH in Eukaryotic Cells. Biochemical Journal, 250, 1-8.
[5] Goerges, A.L. and Nugent, M.A. (2003) Regulation of Vascular Endothelial Growth Factor Binding and Activity by Extracellular pH. The Journal of Biological Chemistry, 278, 19518-19525.
http://dx.doi.org/10.1074/jbc.M211208200
[6] Barry, M.A. and Eastman, A. (1993) Identification of Deoxyribonuclease II as an Endonuclease Involved in Apoptosis. Archives of Biochemistry and Biophysics, 300, 440-450.
http://dx.doi.org/10.1006/abbi.1993.1060
[7] Park, H. and Park, J.Y. (2013) Clinical Significance of AFP and PIVKA-II Responses for Monitoring Treatment Outcomes and Predicting Prognosis in Patients with Hepatocellular Carcinoma. BioMed Research International, 2013, 310427. http://dx.doi.org/10.1155/2013/310427
[8] Clausen, J. and Ovlisen, B. (1965) Lactate Dehydrogenase Isoenzymes of Human Semen. Biochemical Journal, 97, 513-517.
[9] Merke, D.P., Bornstein, S.R. (2005) Congenital Adrenal Hyperplasia. Lancet, 365, 2125-2136.
http://dx.doi.org/10.1016/S0140-6736(05)66736-0

  
comments powered by Disqus

Copyright © 2019 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.