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Correlation of Macular Thickness, Multifocal ERG with Visual Acuity in Oculocutaneous Albinism (OCA)

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DOI: 10.4236/health.2014.616244    3,581 Downloads   3,982 Views  


Background and Aim: Ocular albinism is known to have nystagmus and foveal hypoplasia. A study was done to evaluate the correlation of visual acuity with macular thickness (MT) and mf ERG. Materials and Methods: A total of 20 eyes (10 patients) with OCA were selected. Macular thickness was evaluated with optical coherence tomography and mf ERG was done in all the patients. Results: Mean age was 16.1 ± 7.3 years. The patients were divided into three groups based on their visual acuity > 6/12 (group A), 6/18 - 6/24 (group B), 6/36 or less (group C). Mean MT in patients with visual acuity in group A, B and C was 194.8 ± 26.7, 220 ± 12.3 and 243.5 ± 17.3 microns respectively. The amplitudes of first positive wave (P1) and first negative wave (N1) for the central ring in mf ERG in patients of group A, B and C was 1.1 ± 0.5 (P1), 0.7 ± 0.2 (N1), 0.6 ± 0.5 (P1), 0.3 ± 0.2 (N1), 0.7 ± 0.2 (P1), 0.3 ± 0.1 (N1) microvolts respectively. The vision correlated well with the macular thickness. The mf ERG potentials (P1 and N1) do not correlate with the visual acuity. Conclusion: We believe that the visual acuity in albinotic patients is affected by the macular thickness but the electric potentials do not depend on the visual acuity.

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The authors declare no conflicts of interest.

Cite this paper

Jethani, J. , Jethani, M. , Parmar, S. and Purohit, J. (2014) Correlation of Macular Thickness, Multifocal ERG with Visual Acuity in Oculocutaneous Albinism (OCA). Health, 6, 2109-2114. doi: 10.4236/health.2014.616244.


[1] Nusinowitz, S. and Sarraf, D. (2008) Retinal Function in X-Linked Ocular Albinism (OA1). Current Eye Research, 33, 789-803.
[2] Creel, D., Witkop Jr., C.J. and King, R.A. (1974) Asymmetric Visually Evoked Potentials in Human Albinos: Evidence for Visual System Anomalies. Investigative Ophthalmology, 13, 430-440.
[3] Creel, D., O’Donnell Jr., F.E. and Witkop Jr., C.J. (1978) Visual System Anomalies in Human Ocular Albinos. Science, 201, 931-933.
[4] Russell-Eggitt, I., Kriss, A. and Taylor, D.S. (1990) Albinism in Childhood: A Flash VEP and ERG Study. British Journal of Ophthalmology, 74, 136-140.
[5] Kriss, A., Russell-Eggitt, I. and Taylor, D. (1990) Childhood Albinism. Visual Electrophysiological Features. Ophthalmic Genetics, 11, 185-192.
[6] Seo, J.H., Yu, Y.S., Kim, J.H., Choung, H.K., Heo, J.W. and Kim, S.J. (2007) Correlation of Visual Acuity with Foveal Hypoplasia Grading by Optical Coherence Tomography in Albinism. Ophthalmology, 114, 1547-1551.
[7] Harvey, P.S., King, R.A. and Summers, C.G. (2006) Spectrum of Foveal Development in Albinism Detected with Optical Coherence Tomography. Journal of American Association for Pediatric Ophthalmology and Strabismus, 10, 237-242.
[8] Harvey, P.S., King, R.A. and Summers, C.S. (2008) Foveal Depression and Albinism [Letter]. Ophthalmology, 115, 756; author reply 756-757.
[9] Thomas, M.G., Kumar, A., Mohammad, S., Proudlock, F.A., Engle, E.C., Andrews, C., Chan, W.M., Thomas, S. and Gottlob, I. (2011) Structural Grading of Foveal Hypoplasia Using Spectral-Domain Optical Coherence Tomography: A Predictor of Visual Acuity? Ophthalmology, 118, 1653-1660.
[10] Chong, G.T., Farsiu, S., Freedman, S.F., Sarin, N., Koreishi, A.F., Izatt, J.A. and Toth, C.A. (2009) Abnormal Foveal Morphology in Ocular Albinism Imaged with Spectral-Domain Optical Coherence Tomography. Archives of Ophthalmology, 127, 37-44.
[11] Kelly, J.P. and Weiss, A.H. (2006) Topographical Retinal Function in Oculocutaneous Albinism. American Journal of Ophthalmology, 141, 1156-1158.
[12] Marmor, M.F., Choi, S.S., Zawadzki, R.J. and Werner, J.S. (2008) Visual Insignificance of the Foveal Pit: Reassessment of Foveal Hypoplasia as Fovea Plana. Archives of Ophthalmology, 126, 907-913.

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