Share This Article:

Correlation of Macular Thickness, Multifocal ERG with Visual Acuity in Oculocutaneous Albinism (OCA)

Abstract Full-Text HTML Download Download as PDF (Size:6703KB) PP. 2109-2114
DOI: 10.4236/health.2014.616244    3,581 Downloads   3,982 Views  

ABSTRACT

Background and Aim: Ocular albinism is known to have nystagmus and foveal hypoplasia. A study was done to evaluate the correlation of visual acuity with macular thickness (MT) and mf ERG. Materials and Methods: A total of 20 eyes (10 patients) with OCA were selected. Macular thickness was evaluated with optical coherence tomography and mf ERG was done in all the patients. Results: Mean age was 16.1 ± 7.3 years. The patients were divided into three groups based on their visual acuity > 6/12 (group A), 6/18 - 6/24 (group B), 6/36 or less (group C). Mean MT in patients with visual acuity in group A, B and C was 194.8 ± 26.7, 220 ± 12.3 and 243.5 ± 17.3 microns respectively. The amplitudes of first positive wave (P1) and first negative wave (N1) for the central ring in mf ERG in patients of group A, B and C was 1.1 ± 0.5 (P1), 0.7 ± 0.2 (N1), 0.6 ± 0.5 (P1), 0.3 ± 0.2 (N1), 0.7 ± 0.2 (P1), 0.3 ± 0.1 (N1) microvolts respectively. The vision correlated well with the macular thickness. The mf ERG potentials (P1 and N1) do not correlate with the visual acuity. Conclusion: We believe that the visual acuity in albinotic patients is affected by the macular thickness but the electric potentials do not depend on the visual acuity.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Jethani, J. , Jethani, M. , Parmar, S. and Purohit, J. (2014) Correlation of Macular Thickness, Multifocal ERG with Visual Acuity in Oculocutaneous Albinism (OCA). Health, 6, 2109-2114. doi: 10.4236/health.2014.616244.

References

[1] Nusinowitz, S. and Sarraf, D. (2008) Retinal Function in X-Linked Ocular Albinism (OA1). Current Eye Research, 33, 789-803.
http://dx.doi.org/10.1080/02713680802376353
[2] Creel, D., Witkop Jr., C.J. and King, R.A. (1974) Asymmetric Visually Evoked Potentials in Human Albinos: Evidence for Visual System Anomalies. Investigative Ophthalmology, 13, 430-440.
[3] Creel, D., O’Donnell Jr., F.E. and Witkop Jr., C.J. (1978) Visual System Anomalies in Human Ocular Albinos. Science, 201, 931-933.
http://dx.doi.org/10.1126/science.684419
[4] Russell-Eggitt, I., Kriss, A. and Taylor, D.S. (1990) Albinism in Childhood: A Flash VEP and ERG Study. British Journal of Ophthalmology, 74, 136-140.
http://dx.doi.org/10.1136/bjo.74.3.136
[5] Kriss, A., Russell-Eggitt, I. and Taylor, D. (1990) Childhood Albinism. Visual Electrophysiological Features. Ophthalmic Genetics, 11, 185-192.
http://dx.doi.org/10.3109/13816819009020978
[6] Seo, J.H., Yu, Y.S., Kim, J.H., Choung, H.K., Heo, J.W. and Kim, S.J. (2007) Correlation of Visual Acuity with Foveal Hypoplasia Grading by Optical Coherence Tomography in Albinism. Ophthalmology, 114, 1547-1551.
http://dx.doi.org/10.1016/j.ophtha.2006.10.054
[7] Harvey, P.S., King, R.A. and Summers, C.G. (2006) Spectrum of Foveal Development in Albinism Detected with Optical Coherence Tomography. Journal of American Association for Pediatric Ophthalmology and Strabismus, 10, 237-242.
http://dx.doi.org/10.1016/j.jaapos.2006.01.008
[8] Harvey, P.S., King, R.A. and Summers, C.S. (2008) Foveal Depression and Albinism [Letter]. Ophthalmology, 115, 756; author reply 756-757.
http://dx.doi.org/10.1016/j.ophtha.2007.11.006
[9] Thomas, M.G., Kumar, A., Mohammad, S., Proudlock, F.A., Engle, E.C., Andrews, C., Chan, W.M., Thomas, S. and Gottlob, I. (2011) Structural Grading of Foveal Hypoplasia Using Spectral-Domain Optical Coherence Tomography: A Predictor of Visual Acuity? Ophthalmology, 118, 1653-1660.
http://dx.doi.org/10.1016/j.ophtha.2011.01.028
[10] Chong, G.T., Farsiu, S., Freedman, S.F., Sarin, N., Koreishi, A.F., Izatt, J.A. and Toth, C.A. (2009) Abnormal Foveal Morphology in Ocular Albinism Imaged with Spectral-Domain Optical Coherence Tomography. Archives of Ophthalmology, 127, 37-44.
http://dx.doi.org/10.1001/archophthalmol.2008.550
[11] Kelly, J.P. and Weiss, A.H. (2006) Topographical Retinal Function in Oculocutaneous Albinism. American Journal of Ophthalmology, 141, 1156-1158.
http://dx.doi.org/10.1016/j.ajo.2006.01.045
[12] Marmor, M.F., Choi, S.S., Zawadzki, R.J. and Werner, J.S. (2008) Visual Insignificance of the Foveal Pit: Reassessment of Foveal Hypoplasia as Fovea Plana. Archives of Ophthalmology, 126, 907-913.
http://dx.doi.org/10.1001/archopht.126.7.907

  
comments powered by Disqus

Copyright © 2018 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.