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Oral Bacteria Are Responsible for the Etiology of Rheumatoid Arthritis

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DOI: 10.4236/ojra.2014.43023    2,513 Downloads   3,158 Views   Citations
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ABSTRACT

A significant association has been shown to exist between periodontitis and rheumatoid arthritis (RA) in observational studies. Some intervention studies have suggested that periodontal treatment can reduce serum inflammatory biomarkers such as C-reactive protein, or erythrocyte sedimentation rate. Serum antibodies to oral bacteria have been found at increased levels in RA patients. In addition, DNAs from these bacteria have been identified from samples of RA patients. Several antibiotics are effective on RA. Finally, oral bacteria are responsible for the etiology of RA.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Ogrendik, M. (2014) Oral Bacteria Are Responsible for the Etiology of Rheumatoid Arthritis. Open Journal of Rheumatology and Autoimmune Diseases, 4, 162-169. doi: 10.4236/ojra.2014.43023.

References

[1] Klareskog, L., Catrina, A.I. and Paget, S. (2009) Rheumatoid Arthritis. Lancet, 373, 659-672.
http://dx.doi.org/10.1016/S0140-6736(09)60008-8
[2] Scott, D.L., Wolfe, F. and Huizinga, T.W. (2010) Rheumatoid Arthritis. Lancet, 376, 1094-1108.
http://dx.doi.org/10.1016/S0140-6736(10)60826-4
[3] Cutler, C.W., Kalmar, J.R. and Genco, C.A. (1995) Pathogenic Strategies of the Oral Anaerobe, Porphyromonas gingivalis. Trends Microbiol, 3, 45-51.
http://dx.doi.org/10.1016/S0966-842X(00)88874-5
[4] de Pablo, P., Dietrich, T. and McAlindon, T.E. (2008) Association of Periodontal Disease and Tooth Loss with Rheumatoid Arthritis in the US Population. The Journal of Rheumatology, 35, 70-76.
[5] Pischon, N., Pischon, T., Kroger, J., Gülmez, E., Kleber, B.M., Bernimoulin, J.P., et al. (2008) Association among Rheumatoid Arthritis, Oral Hygiene, and Periodontitis. Journal of Periodontology, 79, 979-986.
http://dx.doi.org/10.1902/jop.2008.070501
[6] Dissick, A., Redman, R.S., Jones, M., Rangan, B.V., Reimold, A., Griffiths, G.R., et al. (2010) Association of Periodontitis with Rheumatoid Arthritis: A Pilot Study. Journal of Periodontology, 81, 223-230.
http://dx.doi.org/10.1902/jop.2009.090309
[7] Ogrendik, M. (2009) Rheumatoid Arthritis Is Linked to Oral Bacteria: Etiological Association. Modern Rheumatology, 19, 453-456.
http://dx.doi.org/10.3109/s10165-009-0194-9
[8] Marotte, H., Farge, P., Gaudin, P., Alexandre, C., Mougin, B. and Miossec, P. (2006) The Association between Periodontal Disease and Joint Destruction in Rheumatoid Arthritis Extends the Link between the HLA-DR Shared Epitope and Severity of Bone Destruction. Annals of the Rheumatic Diseases, 65, 905-909.
http://dx.doi.org/10.1136/ard.2005.036913
[9] De Smit, M., Westra, J., Vissink, A., Van der Meer, B.D., Brouwer, E. and van Winkelhoff, A.J. (2012) Periodontitis in Established Rheumatoid Arthritis Patients: A Cross-Sectional Clinical, Microbiological and Serological Study. Arthritis Research & Therapy, 14, R222.
http://dx.doi.org/10.1186/ar4061
[10] Al-Katma, M.K., Bissada, N.F., Bordeaux, J.M., Sue, J. and Askari, A.D. (2007) Control of Periodontal Infection Reduces the Severity of Active Rheumatoid Arthritis. Journal of Clinical Rheumatology, 13, 134-137.
http://dx.doi.org/10.1097/RHU.0b013e3180690616
[11] Ribeiro, J., Leao, A. and Novaes, A.B. (2005) Periodontal Infection as a Possibleseverity Factor for Rheumatoid Arthritis. Journal of Clinical Periodontology, 32, 412-416.
http://dx.doi.org/10.1111/j.1600-051X.2005.00689.x
[12] Ortiz, P., Bissada, N.F., Palomo, L., Han, Y.W., Al-Zahrani, M.S., Panneerselvam, A. and Askari, A. (2009) Periodontal Therapy Reduces the Severity of Active Rheumatoid Arthritis in Patients Treated with or without Tumor Necrosis Factor Inhibitors. Journal of Periodontology, 80, 535-540.
http://dx.doi.org/10.1902/jop.2009.080447
[13] Marsh, P.D. and Martin, M.V. (2001) Oral Microbiology. 4th Edition, MPG Books Ltd., Bodmin.
[14] Hajishengallis, G., Wang, M., Harokopakis, E., Triantafilou, M. and Triantafilou, K. (2006) Porphyromonas gingivalis Fimbriae Proactively Modulate Beta2 Integrin Adhesive Activity and Promote Binding to and Internalization by Macrophages. Infection and Immunity, 74, 5658-5666.
http://dx.doi.org/10.1128/IAI.00784-06
[15] Kido, J., Kido, R., Suryono, Kataoka, M., Fagerhol, M.K. and Nagata, T. (2003) Calprotectin Release from Human Neutrophils Is Induced by Porphyromonas gingivalis Lipopolysaccharide via the CD-14-Toll-Like Receptor-Nuclear Factor KappaB Pathway. Journal of Periodontal Research, 38, 557-563.
[16] Vossenaar, E.R. and Robinson, W.H. (2005) Citrullination and Autoimmune Disease: 8th Bertine Koperberg Meeting. Annals of the Rheumatic Diseases, 64, 1513-1515.
http://dx.doi.org/10.1136/ard.2005.045716
[17] Coenen, D., Verschueren, P., Westhovens, R. and Bossuyt, X. (2007) Technical and Diagnostic Performance of 6 Assays for the Measurement of Citrullinated Protein/Peptide Antibodies in the Diagnosis of Rheumatoid Arthritis. Clinical Chemistry, 53, 498-504.
http://dx.doi.org/10.1373/clinchem.2006.078063
[18] Nicaise Roland, P., Grootenboer Mignot, S., Bruns, A., Hurtado, M., Palazzo, E., Hayem, G., et al. (2008) Antibodies to Mutated Citrullinated Vimentin for Diagnosing Rheumatoid Arthritis in Anti-CCP-Negative Patients and for Monitoring Infliximab Therapy. Arthritis Research & Therapy, 10, R142.
http://dx.doi.org/10.1186/ar2570
[19] Ogrendik, M., Kokino, S., Ozdemir, F., Bird, P.S. and Hamlet, S. (2005) Serum Antibodies to Oral Anaerobic Bacteria in Patients with Rheumatoid Arthritis. Medscape General Medicine, 7, 2.
[20] Chen, H.H., Chen, D.Y., Lai, K.L., Chen, Y.M., Chou, Y.J., Chou, P., et al. (2013) Periodontitis and Etanercept Discontinuation Risk in Anti-Tumor Necrosis Factor-Naive Rheumatoid Arthritis Patients: A Nationwide Population-Based Cohort Study. Journal of Clinical Rheumatology, 19, 432-438.
http://dx.doi.org/10.1097/RHU.0000000000000041
[21] Kinloch, A., Tatzer, V., Wait, R., Peston, D., Lundberg, K., Donatien, P., et al. (2005) Identification of Citrullinated Alpha-Enolase as a Candidate Autoantigen in Rheumatoid Arthritis. Arthritis Research & Therapy, 7, R1421-1429.
http://dx.doi.org/10.1186/ar1845
[22] Wegner, N., Wait, R., Sroka, A., Eick, S., Nguyen, K.A., Lundberg, K., et al. (2010) Peptidylarginine Deiminase from Porphyromonas gingivalis Citrullinates Human Fibrinogen and α-Enolase: Implications for Autoimmunity in Rheumatoid Arthritis. Arthritis Rheumatology, 62, 2662-2672.
http://dx.doi.org/10.1002/art.27552
[23] Hitchon, C.A., Chandad, F., Ferucci, E.D., Willemze, A., Ioan-Facsinay, A., van der Woude, D., et al. (2010) Antibodies to Porphyromonas gingivalis Are Associated with Anticitrullinated Protein Antibodies in Patients with Rheumatoid Arthritis and Their Relatives. Journal of Rheumatology, 37, 1105-1112.
http://dx.doi.org/10.3899/jrheum.091323
[24] Okada, M., Kobayashi, T., Ito, S., Yokoyama, T., Komatsu, Y., Abe, A., et al. (2011) Antibody Responses to Periodontopathic Bacteria in Relation to Rheumatoid Arthritis in Japanese Adults. Journal of Periodontology, 82, 1433-1441. http://dx.doi.org/10.1902/jop.2011.110020
[25] Mikuls, T.R., Thiele, G.M., Deane, K.D., Payne, J.B., O’Dell, J.R., Yu, F., et al. (2012) Porphyromonas gingivalis and Disease-Related Autoantibodies in Individuals at Increased Risk of Rheumatoid Arthritis. Arthritis Rheumatology, 64, 3522-3530. http://dx.doi.org/10.1002/art.34595
[26] Mikuls, T.R., Payne, J.B., Reinhardt, R.A., Thiele, G.M., Maziarz, E., Cannella, A.C., et al. (2009) Antibody Responses to Porphyromonas gingivalis (P. gingivalis) in Subjects with Rheumatoid Arthritis and Periodontitis. International Immunopharmacology, 9, 38-42.
http://dx.doi.org/10.1016/j.intimp.2008.09.008
[27] Moen, K., Brun, J.G., Valen, M., Skartveit, L., Eribe, E.K., Olsen, I., et al. (2006) Synovial Inflammation in Active Rheumatoid Arthritis and Psoriatic Arthritis Facilitates Trapping of a Variety of Oral Bacterial DNAs. Clinical and Experimental Rheumatology, 24, 656-663.
[28] Martinez-Martinez, R.E., Abud-Mendoza, C., Patino-Marin, N., Rizo-Rodríguez, J.C., Little, J.W. and Loyola-Rodríguez, J.P. (2009) Detection of Periodontal Bacterial DNA in Serum and Synovial Fluid in Refractory Rheumatoid Arthritis Patients. Journal of Clinical Periodontology, 36, 1004-1010.
http://dx.doi.org/10.1111/j.1600-051X.2009.01496.x
[29] Kinane, D.F., Riggio, M.P., Walker, K.F., MacKenzie, D. and Shearer, B. (2005) Bacteraemia Following Periodontal Procedures. Journal of Clinical Periodontology, 32, 708-713.
http://dx.doi.org/10.1111/j.1600-051X.2005.00741.x
[30] Bartold, P.M., Marino, V., Cantley, M. and Haynes, D.R. (2010) Effect of Porphyromonas gingivalis-Induced Inflammation on the Development of Rheumatoid Arthritis. Journal of Clinical Periodontology, 37, 405-411.
http://dx.doi.org/10.1111/j.1600-051X.2010.01552.x
[31] Cantley, M.D., Haynes, D.R., Marino, V. and Bartold, P.M. (2011) Pre-Existing Periodontitis Exacerbates Experi- mental Arthritis in a Mouse Model. Journal of Clinical Periodontology, 38, 532-541.
http://dx.doi.org/10.1111/j.1600-051X.2011.01714.x
[32] Kinloch, A.J., Alzabin, S., Brintnell, W., Wilson, E., Barra, L., Wegner, N., et al. (2011) Immunization with Porphyromonas gingivalis Enolase Induces Autoimmunity to Mammalian α-Enolase and Arthritis in DR4-IE-Transgenic Mice. Arthritis Rheumatology, 63, 3818-3823. http://dx.doi.org/10.1002/art.30639
[33] Mahdi, H., Fisher, B.A., Kallberg, H., Plant, D., Malmstrom, V., Ronnelid, J., et al. (2009) Specific Interaction between Genotype, Smoking, and Autoimmunity to Citrullinated Alpha-Enolase in the Etiology of Rheumatoid Arthritis. Nature Genetics, 41, 1319-1324. http://dx.doi.org/10.1038/ng.480
[34] Maresz, K.J., Hellvard, A., Sroka, A., Adamowicz, K., Bielecka, E., Koziel, J., et al. (2013) Porphyromonas gingivalis Facilitates the Development and Progression of Destructive Arthritis through Its Unique Bacterial Peptidylarginine Deiminase (PAD). Public Library of Science Pathog, 9, e1003627.
http://dx.doi.org/10.1371/journal.ppat.1003627
[35] Svartz, N. (1948) The Treatment of Rheumatic Polyarthritis with Acid Azo Compounds. Rheumatism, 4, 180-185.
[36] McConke, B., Amos, R.S., Durham, S., Forster, P.J., Hubball, S. and Walsh, L. (1980) Sulphasalazine in Rheumatoid Arthritis. British Medical Journal, 280, 442-444.
http://dx.doi.org/10.1136/bmj.280.6212.442
[37] Hoult, J.R. (1986) Pharmacological and Biochemical Actions of Sulphasalazine. Drugs, 32, 18-26.
http://dx.doi.org/10.2165/00003495-198600321-00005
[38] Pullar, T., Hunter, J.A. and Capell, H.A. (1985) Which Component of Sulphasalazine Is Active in Rheumatoid Arthritis? British Medical Journal (Clinical Research Education), 290, 1535-1538.
http://dx.doi.org/10.1136/bmj.290.6481.1535
[39] Ash, G., Baker, R., Rajapakse, C. and Swinson, D.R. (1986) Study of Sulphamethoxazole in Rheumatoid Arthritis. British Journal of Rheumatology, 25, 285-287.
http://dx.doi.org/10.1093/rheumatology/25.3.285
[40] Ostrander, F.D. (1948) Vitamins, Sulfonamides and Antibiotics in Periodontal Therapy. Journal of the American Dental Association, 37, 279-288.
[41] Felson, D.T., Anderson, J.J. and Meenan, R.F. (1992) Use of Short-Term Efficacy/Toxicity Tradeoffs to Select Second-Line Drugs in Rheumatoid Arthritis. A Metaanalysis of Published Clinical Trials. Arthritis Rheumatology, 35, 1117-1125. http://dx.doi.org/10.1002/art.1780351003
[42] Weinblatt, M.E., Reda, D., Henderson, W., et al. (1999) Sulfasalazine Treatment for Rheumatoid Arthritis: A Metaanalysis of 15 Randomized Trials. Journal of Rheumatology, 26, 2123-2130.
[43] Garrido-Mesa, N., Zarzuelo, A. and Gálvez, J. (2013) Minocycline: Far beyond an Antibiotic. British Journal of Pharmacology, 169, 337-352. http://dx.doi.org/10.1111/bph.12139
[44] Kloppenburg, M., Breedveld, F.C., Terwiel, J.P., Mallee, C. and Dijkmans, B.A. (1994) Minocycline in Active Rheumatoid Arthritis. A Double-Blind, Placebo-Controlled Trial. Arthritis Rheumatology, 37, 629-636.
http://dx.doi.org/10.1002/art.1780370505
[45] Tilley, B.C., Alarcón, G.S., Heyse, S.P., et al., MIRA Trial Group (1995) Minocycline in Rheumatoid Arthritis. A 48-Week, Double-Blind, Placebo-Controlled Trial. Annals of International Medicine, 122, 81-89.
http://dx.doi.org/10.7326/0003-4819-122-2-199501150-00001
[46] Langevitz, P. Livneh, A., Bank, I. and Pras, M. (2000) Benefits and Risks of Minocycline in Rheumatoid Arthritis. Drug Safety, 22, 405-414. http://dx.doi.org/10.2165/00002018-200022050-00007
[47] Stone, M. Fortin, P.R., Pacheco-Tena, C. and Inman, R.D. (2003) Should Tetracycline Treatment Be Used More Extensively for Rheumatoid Arthritis? Metaanalysis Demonstrates Clinical Benefit with Reduction in Disease Activity. Journal of Rheumatology, 30, 2112-2122.
[48] Kwiatkowska, B. and Maslińska, M. (2012) Macrolide Therapy in Chronic Inflammatory Diseases. Mediators of Inflammation, 2012, Article ID: 636157. http://dx.doi.org/10.1155/2012/636157
[49] Saviola, G., Abdi Ali, L., Rossini, P., et al. (2002) Clarithromycin in Rheumatoid Arthritis Patients Not Responsive to Disease-Modifying Antirheumatic Drugs: An Open, Uncontrolled Pilot Study. Clinical and Experimental Rheumatology, 20, 373-378.
[50] Saviola, G., Abdi-Ali, L., , L., et al. (2013) Clarithromycin in Rheumatoid Arthritis: The Addition to Methotrexate and Low-Dose Methylprednisolone Induces a Significant Additive Value—A 24-Month Single-Blind Pilot Study. Rheumatology International, 33, 2833-2838.
http://dx.doi.org/10.1007/s00296-013-2822-0
[51] Ogrendik, M. (2007) Effects of Clarithromycin in Patients with Active Rheumatoid Arthritis. Current Medicine Research and Opinion, 23, 515-522. http://dx.doi.org/10.1185/030079906X167642
[52] Ogrendik, M. (2009) Efficacy of Roxithromycin in Adult Patients with Rheumatoid Arthritis Who Had Not Received Disease-Modifying Antirheumatic Drugs: A 3-Month, Randomized, Double-Blind, Placebo-Controlled Trial. Clinical Therapeutics, 31, 1754-1764.
http://dx.doi.org/10.1016/j.clinthera.2009.08.014
[53] Ogrendik, M. and Karagoz, N. (2011) Treatment of Rheumatoid Arthritis with Roxithromycin: A Randomized Trial. Postgraduate Medicine, 123, 220-227. http://dx.doi.org/10.3810/pgm.2011.09.2478

  
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