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Expression of MMP-9 and -13 on the Pressure Side under Orthodontic Loading

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DOI: 10.4236/ojst.2014.48055    2,161 Downloads   2,507 Views  

ABSTRACT

Purpose: The purpose of this study was to investigate the expression of MMP-9 and MMP-13 on compression side of tooth movement. Material and Methods: Twenty male Wistar rats were used for this experiment. Maxillary right first molar was moved orthodontically with a constant force of 20 g and on the side of the maxillary left first molar was used as control group. On the 4th, 10th and 17th days after experiment, 5 rats were euthanized, respectively. Histologic process was processed for immunohistochemical staining of MMP-9 and -13. Results: MMP-9 and -13 expressions were upregulated at day 4 after tooth movement. The expression of MMP-9 was not observed at days 7, 10 and 14, while the expression of MMP-13 was greatly increased at days 7 and 10. Conclusion: This study suggests that different characteristics of MMPs expression may contribute to the remodeling process of collagen fibers in the PDL during tooth movement.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Mah, S. , Lee, Y. , Chun, Y. and Lim, W. (2014) Expression of MMP-9 and -13 on the Pressure Side under Orthodontic Loading. Open Journal of Stomatology, 4, 412-417. doi: 10.4236/ojst.2014.48055.

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