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Effects of Age on the Disruption of Cognitive Performance by Exposure to Space Radiation

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DOI: 10.4236/jbbs.2014.47031    2,431 Downloads   3,329 Views   Citations


Exposure to low doses of heavy particles and protons, which will be encountered during long-term exploratory class missions to other planets, can cause deficits in cognitive performance. These deficits are similar to those observed in aged animals. The long-term effects of such exposures and their relationship to the short-term effects and to aging remain to be established. Two-month old rats were exposed to a variety of heavy particles and protons. Recognition memory was tested at two time points following irradiation. The results showed that exposure to doses of radiation that did not disrupt cognitive performance in the younger animals, disrupted performance when the subjects were re-tested at an older age. These results indicate that there is an interaction between the age of the organism and the effects of exposure to space radiation on cognitive performance, such that exposure to doses of heavy particles or protons that may not produce an initial effect on cognitive performance may produce an effect as the organism ages. Because of the interaction between exposure to the types of radiation encountered in space and age, it is possible that participating in exploratory class missions may have consequences for the quality of life after the conclusion of the mission.

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The authors declare no conflicts of interest.

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Rabin, B. , Shukitt-Hale, B. and Carrihill-Knoll, K. (2014) Effects of Age on the Disruption of Cognitive Performance by Exposure to Space Radiation. Journal of Behavioral and Brain Science, 4, 297-307. doi: 10.4236/jbbs.2014.47031.


[1] Cucinotta, F.A., Schimmerling, W., Saganti, P.B., Wilson, J.W., Peterson, L.E., Badhwar, G.D. and Dicello, J.F. (2001) Space Radiation Cancer Risks and Uncertainties for Mars Missions. Radiation Research, 156, 682-688.[0682:SRCRAU]2.0.CO;2
[2] Edwards, A.A. (2001) RBE of Radiations in Space and the Implications for Space Travel. Physica Medica, 27, 147-152.
[3] Schimmerling, W., Cucinotta, F.A. and Wilson, J.A. (2003) Radiation Risk and Human Space Exploration. Advances in Space Research, 3, 27-34.
[4] Joseph, J.A., Hunt, W.A., Rabin, B.M. and Dalton, T.K. (1992) Possible “Accelerated Aging” Induced by 56Fe Heavy Particle Irradiation: Implications for Manned Space Flights. Radiation Research, 130, 88-93.
[5] Joseph, J.A., Hunt, W.A., Rabin, B.M., Dalton, T.K. and Harris, A.H. (1993) Deficits in Striatal Muscarinic Receptor Sensitivity Induced by 56Fe Heavy Particle Irradiation: Further “Age-Radiation” Parallels. Radiation Research, 135, 257-261.
[6] Shukitt-Hale, B., Casadesus, G., Carey, A., Rabin, B.M. and Joseph, J.A. (2007) Exposure to 56Fe Irradiation Accelerates Normal Brain Aging and Produces Deficits in Learning and Memory. Advances in Space Research, 39, 1087-1092.
[7] Rabin, B.M., Buhler, L.L., Joseph, J.A., Shukitt-Hale, B. and Jenkins, D.G. (2002) Effects of Exposure to 56Fe Particles or Protons on Fixedratio Operant Responding in Rats. Journal of Radiation Research, 43, S225-S228.
[8] Villasana, L., Rosenberg, J. and Raber, J. (2010) Sex-Dependent Effects of 56Fe Irradiation on Contextual Fear Conditioning in C57BL/6J Mice. Hippocampus, 26, 19-23.
[9] Raber, J., Rosi, S., Chakraborti, A., Fishman, K., Dayger, C., et al. (2011) Effects of 56Fe-Particle Cranial Radiation on Hippocampus-Dependent Cognition Depend on the Salience of Environmental Stimuli. Radiation Research, 176, 521-527.
[10] Shukitt-Hale, B., Casadesus, G., McEwen, J.J., Rabin, B.M. and Joseph, J.A. (2000) Spatial Learning and Memory Deficits Induced by 56Fe Radiation Exposure. Radiation Research, 154, 28-33.[0028:SLAMDI]2.0.CO;2
[11] Rabin, B.M., Joseph, J.A. and Shukitt-Hale, B. (2005) A Longitudinal Study of Operant Responding in Rats Irradiated when 2 Months Old. Radiation Research, 164, 552-555.
[12] Rabin, B.M., Joseph, J.A., Shukitt-Hale, B. and Carrihill-Knoll, K.L. (2012) Interaction between Age of Irradiation and Age of Testing in the Disruption of Operant Performance Using a Ground-Based Model for Exposure to Cosmic Rays. AGE, 34, 121-131.
[13] Rabin, B.M., Carrihill-Knoll, K.L., Hinchman, M., Shukitt-Hale, B., Joseph, J.A., et al. (2009) Effects of Heavy Particle Irradiation and Diet on Object Recognition Memory in Rats. Advances in Space Research, 43, 1193-1199.
[14] Curtis, S.B., Vazquez, M.E., Wilson, J.W., Atwell, W., Kim, M. and Capala, J. (1998) Cosmic Ray Hit Frequencies in Critical Sites in the Central Nervous System. Advances in Space Research, 22, 197-207.
[15] Zeitlin, C., Hassler, D.M., Cucinotta, F.A., et al. (2013) Measurements of Energetic Particle Radiation in Transit to Mars on the Mars Science Laboratory. Science, 340, 1080-1084.
[16] Rabin, B.M., Carrihill-Knoll, K.L., Carey, A.N., Shukitt-Hale, B., Joseph, J.A. and Foster, B.C. (2007) Elevated Plusmaze Performance of Fischer-344 Rats as a Function of Age and Exposure to 56Fe Particles. Advances in Space Research, 39, 981-986.
[17] Malin, D.H., Lee, D.R., Goyarzu, P., Chang, Y.-H., Ennis, L.J., et al. (2011) Short-Term Blueberry-Enriched Diet Prevents and Reverses Object Recognition Memory Loss in Aging Rats. Nutrition, 27, 338-342.
[18] Weinstock, M., Bejar, C., Schorer-Apelbaum, D., Panarsky, R., Luques, L., et al. (2013) Dose-Dependent Effects of Ladostigil on Microglial Activation and Cognition in Aged Rats. Journal of Neuroimmune Pharmacology, 8, 345-355.
[19] Rabin, B.M., Carrihill-Knoll, K.L. and Shukitt-Hale, B. (2011) Operant Responding Following Exposure to HZE Particles and its Relationship to Particle Energy and Linear Energy Transfer. Advances in Space Research, 48, 370-377.
[20] Lee, W.H., Sonntag, W.E., Mitschelen, M., Yan, H. and Lee, W.L. (2010) Irradiation Induces Regionally Specific Alterations in Pro-inflammatory Environments in Rat Brain. International Journal of Radiation Biology, 86, 132-144.
[21] Barja, G. (2004) Free Radicals and Aging. Trends in Neuroscience, 27, 595-600.
[22] Bokov, A. Chaudhuri, A. and Richardson, A. (2004) The Role of Oxidative Damage and Stress in Aging. Mechanisms of Aging and Development, 125, 811-826.
[23] Floyd, R.A. and Hensley, K. (2002) Oxidative Stress in Brain Aging: Implications for Therapeutics of Neurodegenerative Diseases. Neurobiology of Aging, 23, 795-807.
[24] Ashok, A. and Ali, R. (1999) The Aging Paradox: Free Radical Theory of Aging. Experimental Gerontology, 34, 293-303.
[25] Norden, D.M. and Godbout, J.A. (2013) Review: Microglia of the Aged Brain: Primed to Be Activated and Resistant to Regulation. Neuropathology and Applied Neurobiology, 39, 19-34.
[26] Pizza, V., Agresta, A., D’Acunto, C.W., Festa, M. and Capasso, A. (2011) Neuroinflamm-Aging and Neurodegenerative Diseases: An Overview. CNS & Neurolog-ical Disorders Drug Targets, 10, 621-634.
[27] Ownby, R.L. (2010) Neuroinflammation and Cognitive Aging. Current Psychiatry Reports, 12, 39-45.
[28] Hein, A.M. and O’Banion, M.K. (2012) Neuroinflammation and Cognitive Dysfunction in Chronic Disease and Aging. Journal of Neuroimmune Pharmacology, 7, 3-62.
[29] Chen, J., Buchanan, J.B., Sparkman, N.L., Godbout, J.P., Freund, G.G. and Johnson, R.W. (2008) Neuroinflammation and Disruption in Working Memory in Aged Mice after Acute Stimulation of the Peripheral Innate Immune System. Brain Behavior and Immunity, 22, 301-311.
[30] Riley, P.A. (1994) Free Radicals in Biology: Oxidative Stress and the Effects of Ionizing Radiation. International Journal of Radiation Biology, 65, 27-33.
[31] Denisova, N., Shukitt-Hale, B., Rabin, B.M. and Joseph, J.A. (2002) Brain Signaling and Behavioral Responses Induced by Exposure to 56Fe Radiation. Radiation Research, 158, 725-734.[0725:BSABRI]2.0.CO;2
[32] Poulose, S.M., Bielinski, D.F., Carrihill-Knoll, K.L, Rabin, B.M. and Shukitt-Hale, B. (2011) Exposure to Oxygen (16O) Particle Irradiation Causes Age-Like Decrements in Rats Through Increased Oxidative Stress, Inflammation and Loss of Autophagy. Radiation Research, 176, 761-769.
[33] Rola, R., Sarkissian, V., Obenaus, A., Nelson, G.A., Otsuka, S., et al. (2005) High-LET Radiation Induces Inflammation and Persistent Changes in Markers of Hippocampal Neurogenesis. Radiation Research, 164, 556-560.
[34] Jenrow, K.A., Brown, S.L., Lapanowski, K., Naei, H., Kolozsvary, A. and Kin, J.H. (2012) Selective Inhibition of Microglia-Mediated Neuroinflammation Mitigates Radiation-Induced Cognitive Impairment. Radiation Research, 179, 549-556.

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