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Comparative Study between the Effect of Momordica charantia (Wild Type) Fruits and Coccinia cordifolia’s Leaf on Hypoglycemic and Hypolipidemic Activities of Alloxan

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DOI: 10.4236/jdm.2014.42018    2,529 Downloads   3,488 Views   Citations

ABSTRACT

Aims: The study was aimed to compare the hypoglycemic and hypolipidemic effect of Momordica charantia (wild type) fruits and Coccinia cordifolia’s leaf in alloxan induced type 2 diabetic Long-Evans rats. Methods: All rats were divided into groups A to H (n = 48, 06 rats per group). They were made diabetic by intraperitoneally injecting alloxan monohydrate 150-mg/Kg-body weight. Groups A and B were provided with normal diet and glibenclamide plus normal diet respectively. C to H groups were provided with different percentages (70%, 50% and 30% of regular diet) of samples. Different biochemical parameters (blood glucose level, serum total cholesterol, triglyceride (TG), LDL, HDL, serum insulin, hepatic glycogen) were observed for 21 consecutive days (at eight days interval). Results: Oral administration of both of the Momordica charantia (wild type) fruits and Coccinia cordifolia’s leaf significantly (p < 0.05) improved hypoglycemic status by decreasing fasting blood glucose level. Hypolipidemic status also observed, and found improved significantly (p < 0.05) by decreasing the level of serum total cholesterol, triglyceride (TG), serum insulin level and LDL in type 2 diabetic rats. HDL levels were increased slightly and hepatic glycogen level was more or less unchanged in both groups at 22nd day. Conclusion: Though both samples show hypoglycemic and hypolipidemic activities, 50% wild type fruits of Momordica charantia were more significant (p < 0.05) to ameliorate the diabetic state in type 2 diabetic Long-Evans rats.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Islam, D. , Lipy, E. , Rahman, S. , Mohanta, L. and Babi, K. (2014) Comparative Study between the Effect of Momordica charantia (Wild Type) Fruits and Coccinia cordifolia’s Leaf on Hypoglycemic and Hypolipidemic Activities of Alloxan. Journal of Diabetes Mellitus, 4, 115-123. doi: 10.4236/jdm.2014.42018.

References

[1] Ogbonnia Steve, O., Odimegwu Joy, I. and Enwuru Veronica, N. (2008) Evaluation of Hypoglycemic and Hypolipidemic Effects of Ethanolic Extracts of Treculia africana Decne and Bryophyllum pinnatum Lam. and Their Mixture on Streptozotocin (STZ)-Induced Diabetic Rats. African Journal of Biotechnology, 7, 2535-2539.
[2] Edem, D.O. (2009) Hypoglycemic Effects of Ethanolic Extracts of Alligator Pear Seed (Persea Americana Mill) in Rats. European Journal of Scientific Research, 33, 669-678.
[3] Kristova, V., Liskoya, S., Sotnikova, S., Vojtko, R. and Kurtansky, A. (2008) Sulodexide Improves Endothelia Dysfunction in Streptozotocin-Induced Diabetes in Rats. Physiological Research, 5, 491-494.
[4] Bastaki, S. (2005) Review Diabetes Mellitus and Its Treatment. International Journal of Diabetes and Metabolism, 13, 111-134.
[5] King, H., Auburt, R.E. and Herman, W.H. (1998) Global Burden of Diabetes 1995-2025: Prevalance, Numerical Estimates and Projections. Diabetes Care, 21, 1414-1431.
http://dx.doi.org/10.2337/diacare.21.9.1414
[6] Ramachandran, A., Snehlatha, C., Kapur, A., Vijay, V., Mohan, V., Das, A.K., et al. (2001) Diabetes Epidemiology Study Group in India (DESI): High Prevalence of Diabetes and Impaired Glucose Tolerance in India: National Urban Diabetes Survey (NUDS). Diabetologia, 44, 1094-1100.
http://dx.doi.org/10.1007/s001250100627
[7] Sayeed, M.A., Rumi, M.A.K, Ali, L., Banu, A., Hussain, Z.A. and Azad Khan, A.K. (2007) Effect of Socioeconomic Risk Factors on the Difference in Prevalence of Diabetes between Rural and Urban Populations in Bangladesh. Biological Medical Research Council, 33, 1-12.
[8] Aslam, M. and Stockley, I.H. (1979) Interaction between Curry Ingredient and Drug. Lancet, 313, 607. http://dx.doi.org/10.1016/S0140-6736(79)91028-6
[9] Cupts, S.S. and Seth, C.B. (1982) Effect of Momordica Charentia Linn. (Karela) on Glucose Tolerance in Albino Rats. Journal of the Indian Medical Association, 39, 581-584.
[10] Wang, W., Miura, T., Shi, H., Ma, D.M., Zhao, Q.D., Zhang, W.P., Ishihara, E., Kanehara, M., Zhang, B.L., Gao, X, M., Zhang, DQ. and Ishida, T. (2008) Effect of Tangzhiqing on Glucose and Lipid Metabolism in Genetically Type 2 Diabetes KK-Ay Mice. Journal of Health Science, 54, 203-206.
http://dx.doi.org/10.1248/jhs.54.203
[11] Konkon, N.G., Adjoungoua, A.L., Manda, P., Simaga, D., N’Guessan, K.E. and Kone, B.D. (2010) Toxicological and Phytochemical Screening Study of Mitragyna Inermis (Willd.) O ktze (Rubiaceae), Anti Diabetic Plant. Journal of Medicinal Plants Research, 2, 279-284.
[12] Rajagopal, K. and Sasikala, K. (2008) Antihyperglycaemic and Antihyperlipidaemic Effects of Nymphaea stellata in Alloxan-Induced Diabetic Rats. Singapore Medical Journal, 49, 137-141.
[13] Saha, S.K., Haque, Md.E., Islam, D., Rahman, Md.M., Islam, Md.R., Parvin, A. and Rahman, S. (2012) Comparative Study between the Effect of Momordica charantia (Wild and Hybrid Variety) on Hypoglycemic and Hypolipidemic Activity of Alloxan Induced Type 2 Diabetic Long-Evans Rats. Journal of Diabetes Mellitus, 2, 131-137. http://dx.doi.org/10.4236/jdm.2012.21022
[14] Haque, E., Saha, S.K., Islam, D. and Islam, R. (2012) Comparative Study between the Effect of Coccinia cordifolia (Leaf and Root) Powder on Hypoglycemic and Hypolipidemic Activity of Alloxan Induced Type 2 Diabetic Long-Evans Rats. Journal of Diabetes and Endocrinology, 3, 37-43.
http://dx.doi.org/10.5897/JDE11.018
[15] Shirwaikar, A., Rajendran, K. and Barik, R. (2006) Effect of Aqueous Bark Extracts of Garuga pinnata in Streptozotocin-Nicotinamide Induced Type-II Diabetes Mellitus. Journal of Ethnopharmacology, 107, 285-290. http://dx.doi.org/10.1016/j.jep.2006.03.012

  
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