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Effect of Carbohydrate Intolerance and Gestational Diabetes on Obstetric and Perinatal Outcomes

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DOI: 10.4236/ojog.2014.46040    3,935 Downloads   5,137 Views  

ABSTRACT

Objectives: To compare the frequency of obstetric and perinatal complications among patients with carbohydrate intolerance (CHI) and gestational diabetes (GD). Materials and Methods: In a prospective study at the Civil Hospital of Culiacán, we studied 182 pregnant patients between 16 and 30 weeks of gestation (WG) who received a glucose tolerance test following the oral administration of 100 g of glucose. The patients were classified as normal (n = 53), CHI (n = 61) and GD (n = 68) between January 15 to November 30, 2012. The analyzed variables included the frequency of polyhydramnios, preeclampsia-eclampsia, obstetric hemorrhage, fetal macrosomia, and admission to a neonatal intensive care unit (NICU). Results: No significant differences were found between women with CHI and women with GD with respect to obstetric hemorrhage (P = 0.774), preeclampsia-eclampsia (P = 0.590), and macrosomia (P = 0.119). However, polyhydramnios was more frequent in CHI group (OR = 3) compared to GD, whereas admission to the NICU was lower in the CHI group compared to GD group (OR = 0.38). Conclusion: Preeclampsia-eclampsia, obstetric hemorrhage, and macrosomia were similar among patients with CHI and GD. In contrast, polyhydramnios was more frequent in patients with CHI compared to patients with GD, but admission to the NICU was more frequent in patients with GD.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Lara-Ávila, L. , Brambila-Durán, J. , Camacho-Ramírez, D. , Peraza-Garay, F. , Herrera-Salazar, A. and Morgan-Ortiz, F. (2014) Effect of Carbohydrate Intolerance and Gestational Diabetes on Obstetric and Perinatal Outcomes. Open Journal of Obstetrics and Gynecology, 4, 243-248. doi: 10.4236/ojog.2014.46040.

References

[1] WHO (1999) Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complications. Report of World Health Organization Consultation. WHO, Geneva.
[2] Meltzer, S.J., Snyder, J., Penrod, J.R., Nudi, M. and Morin, L. (2010) Gestational Diabetes Mellitus Screening and Diagnosis: A Prospective Randomized Controlled Trial Comparing Costs of One-Step and Two-Step Methods. BJOG, 117, 407-415. http://dx.doi.org/10.1111/j.1471-0528.2009.02475.x
[3] Jimenez-Moleon, J.J., Bueno-Cavanillas, A., Luna-Del-Castillo, J.D., Garcia-Martin, M., Lardelli-Claret, P. and Galvez-Vargas, R. (2002) Prevalence of Gestational Diabetes Mellitus: Variations Related to Screening Strategy Used. European Journal of Endocrinology, 146, 831-837.
http://dx.doi.org/10.1530/eje.0.1460831
[4] Ramirez-Torres, M.A. (2005) Gestational Diabetes Mellitus, Experience at a Third Level Hospital. Ginecología y Obstetricia de México, 73, 484-491.
[5] Moses, R.G. (2010) New Consensus Criteria for GDM: Problem Solved or a Pandora’s Box? Diabetes Care, 33, 690-691. http://dx.doi.org/10.2337/dc09-2306
[6] Di Cianni, G., Seghieri, G., Lencioni, C., Cuccuru, I., Anichini, R., De Bellis, A., et al. (2007) Normal Glucose Tolerance and Gestational Diabetes Mellitus: What Is in between? Diabetes Care, 30, 1783-1788. http://dx.doi.org/10.2337/dc07-0119
[7] International Association of Diabetes and Pregnancy Study Groups Consensus Panel (2010) International Association of Diabetes and Pregnancy Study Groups Recommendations on the Diagnosis and Classification of Hyperglycemia in Pregnancy. Diabetes Care, 33, 676-682.
http://dx.doi.org/10.2337/dc09-1848
[8] Waugh, N., Royle, P., Clar, C., Henderson, R., Cummins, E., Hadden, D., et al. (2010) Screening for Hyperglycaemia in Pregnancy: A Rapid Update for the National Screening Committee. Health Technological Assessment, 14, 1-183.
[9] Ministry of Health (2009) Clinical Practice, Diagnosis, and Treatment Guidelines for Diabetes in Pregnancy.
[10] HAPO Study Cooperative Research Group (2008) Hyperglycemia and Adverse Pregnancy Outcomes. New England Journal of Medicine, 358, 1991-2002. http://dx.doi.org/10.1056/NEJMoa0707943
[11] Mestzger, B.E. and Coustan, D.R. (1998) Summary and Recommendations of the Fourth International Workshop-Conference on Gestational Diabetes Mellitus. The Organizing Committee. Diabetes Care, 21, B161-B167.
[12] Basevi, V., Di Mario, S., Morciano, C., Nonino, F. and Magrini, N. (2011) Commnent on: American Diabetes Association. Standards of Medical Care in Diabetes-2011. Diabetes Care, 34, S11-S61. http://dx.doi.org/10.2337/dc11-S011
[13] American College of Obstetricians and Gynecologists (2011) Committee Opinion No. 504. Screening and Diagnosis of Gestational Diabetes Mellitus. Obstetrics & Gynecology, 118, 751-753.
http://dx.doi.org/10.1097/AOG.0b013e3182310cc3
[14] Reyes-Munoz, E., Parra, A., Castillo-Mora, A. and Ortega-González, C. Effect of Diagnostic Criteria of the International Association of Diabetes and Pregnancy Study Groups on the Prevalence of Gestational Diabetes Mellitus in Urban Mexican Women: A Cross-Sectional Study. Endocrine Practice, 18, 146-151. http://dx.doi.org/10.4158/EP11167.OR
[15] Ortega-González, C., Ballesteros, A., Casanueva, E., Fonseca, T., Cacique, E. and Parra, A. (2008) Searching for Alternative Methods and Diagnosing Gestational Diabetes Mellitus in a Mexican Urban Population. Medical Science Monitor, 148, CR598-CR603.
[16] Nolasco-Blé, A.K., Hernandez-Herrera, R.J. and Ramos-González, R.M. (2012) Perinatal Outcomes in Pregnancies of Advanced Maternal Age. Ginecología y Obstetricia de México, 80, 270-275.
[17] Schaefer-Graf, U., Kjos, S., Kilavuz, O., Plagemann, A., Brauer, M., Dudenhausen, J., et al. (2003) Determinants of Fetal Growth at Different Periods of Pregnancies Complicated by Gestational Diabetes Mellitus or Impaired Glucose Tolerance. Diabetes Care, 26, 193-198.
http://dx.doi.org/10.2337/diacare.26.1.193
[18] Landon, M.B., Spong, C.Y., Thom, E., Carpenter, M.W., Ramin, S.M., Casey, B., et al. (2009) A Multicenter, Randomized Trial of Treatment for Mild Gestational Diabetes. New England Journal of Medicine, 361, 1339-1348. http://dx.doi.org/10.1056/NEJMoa0902430

  
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