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Serum lipid growth curves for children and adolescents in predicting adult dyslipidemia (Data from the Slovak Lipid Community Study)

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DOI: 10.4236/abc.2013.35045    3,834 Downloads   5,343 Views   Citations

ABSTRACT

Objectives: To create age- and sex-specific growth curves for serum lipids in Slovak children and adolescents, and to compare age- and sex-specific cut-off points with the currently recommended procedure using a single set of risk values for the whole child and adolescent population. Methods: Data were extracted from a cross-sectional Slovak Lipid Community Study conducted in 2005-2007; 873 healthy chil- dren and adolescents aged 7 - 18 years were selected for this study. Smoothed percentile curves were generated by LMS Pro software. Results: All lipid parameters (except for total cholesterol and LDL-cholesterol in girls) were higher in puberty than in adolescence, with the lowest serum lipids between the ages of 15 and 16 years. Mean triglyceride levels were higher in girls than in boys in all age groups. At the age of 18 years, about 19% boys and 25% girls had borderline and 6% boys and 15% girls had elevated total cholesterol. Elevated triglyceride levels were seen in 13% of boys and 11% of girls while abnormally low levels of HDL-cholesterol were found in 17% of boys and 10% of girls. Conclusions: The results of this study suggest that 1) age and gender play a strong role in lipid measurements in children and adolescents, 2) Slovak children and adolescents have a relative high proportion of abnormal lipid levels, and 3) age- and sex-specific cut-off points for serum lipids could be used to identify children and adolescents with an elevated risk of dyslipidemia in adulthood.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Roman Alberty, R. and Albertyová, D. (2013) Serum lipid growth curves for children and adolescents in predicting adult dyslipidemia (Data from the Slovak Lipid Community Study). Advances in Biological Chemistry, 3, 419-426. doi: 10.4236/abc.2013.35045.

References

[1] Khot, U.N., Khot M.B., Bajzer, T.C., Sapp, S.K., Ohman, E.M., Brener, S.J., Ellis, S.G., Lincoff, A.M. and Topol, E.J. (2003) Prevalence of conventional risk factors in patients with coronary heart disease. JAMA, 290, 898-904. http://dx.doi.org/10.1001/jama.290.7.898
[2] McGill, H.C. jr., McMahan, C.A., Malcom, G.T., Oalmann, M.C. and Strong, J.P. (1997) Effects of serum lipoproteins and smoking on atherosclerosis in young men and women. The PDAY Research Group. Pathobiological Determinants of Atherosclerosis in Youth. Arteriosclerosis, Thrombosis, and Vascular Biology, 17, 95-106.
http://dx.doi.org/10.1161/01.ATV.17.1.95
[3] National Cholesterol Education Program (NCEP). Highlights of the report of the expert panel on blood cholesterol levels in children and adolescents (1992) Pediatrics, 59, 495-501.
[4] Recommendations for diagnosis and treatment of dyslipidemia in children and adolescents (2011) Cardiology Letters, 20, 254-261.
[5] Morrison, J.A., Barton, B.A., Biro, F.M. and Sprecher, D.L. (2003) Sex hormones and the changes in adolescent male lipids: longitudinal studies in a biracial cohort. Journal of Pediatrics, 142, 637-642.
http://dx.doi.org/10.1067/mpd.2003.246
[6] Jelenkovic, A., Bogl, L.H., Rose, R.J., Kangas, A.J., Soininen, P., Ala-Korpela, M., Kaprio, J. and Silventoinen, K. (2013) Association of height and pubertal timing with lipoprotein subclass profile: Exploring the role of genetic and environmental effects. American Journal of Human Biology, 25, 465-472.
http://dx.doi.org/10.1002/ajhb.22381
[7] Madhavan, M., Pandey, R.M., Misra, A., Vikram, N.K., Dhingra, V., Luthra, K. and Wasir, J.S. (2005) Centile values for serum lipids and blood pressure for Asian Indian adolescents. Lipids in Health and Disease, 4, 20.
http://dx.doi.org/10.1002/ajhb.22381
[8] Alberty, R., Albertyová, D. and Ahlers, I. (2009) Distribution and correlations of non-high-density lipoprotein cholesterol in Roma and Caucasian children: The Slovak Lipid Community Study. Collegium Antropologicum, 4, 1015-1022.
[9] Alberty, R. and Albertyová, D. (2012) Lipoprotein(a) in children of Asian Indian descendants and their Caucasian neighbors: The Slovak Lipid Community Study. Indian Journal of Clinical Biochemistry, 27, 231-238.
http://dx.doi.org/10.1007/s12291-012-0196-9
[10] Friedewald, W.T., Levy, R.I. and Fredrickson, D.S. (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultra-centrifuge. Clinical Chemistry, 18, 499-502.
[11] Cole, T.J. (1990) The LMS method for constructing normalized growth standards. European Journal of Clinical Nutrition, 44, 45-60.
[12] Naito, H.K. (1996) Coronary artery disease and disorders of lipid metabolism. In: Kaplan, L.A. and Pesce, A.J., Eds., Clinical Chemistry: Theory, Analysis, and Correlation, Mosby, St. Louis, 642-681.
[13] Kit, B.K., Carroll, M.D., Lacher, D.A., Sorlie, P.D., De-Jesus, J.M. and Ogden, C. (2012) Trends in serum lipids among US youths aged 6 to 19 years, 1988-2010. JAMA, 308, 591-600.
http://dx.doi.org/10.1001/jama.2012.9136
[14] Marwaha, R.K., Khadgawat, R., Tandon, N., Kanwar, R., Narang, A., Sastry, A. and Bhadra, K. (2011) Reference intervals of serum lipid profile in healthy Indian school children and adolescents. Clinical Biochemistry, 44, 760-766.
http://dx.doi.org/10.1016/j.clinbiochem.2011.05.011
[15] Gidding, S.S., Stone, N.J., Bookstein, L.C., Laskarzewski, P.M. and Stein, E.A. (1998) Month-to-month variability of lipids, lipoproteins, and apolipoproteins and the impact of acute infection in adolescents. Journal of Pediatrics, 133, 242-246.
http://dx.doi.org/10.1016/S0022-3476(98)70227-6
[16] Niinikoski, H. and Routtinen, S. (2012) Is carbohydrate intake in the first years of life related to future risk of NCDs? Nutrition, Metabolism & Cardiovascular Diseases, 22, 770-774.
http://dx.doi.org/10.1016/j.numecd.2012.05.002
[17] Cook, S., Auinger, P. and Huang, T.T. (2009) Growth curves for cardio-metabolic risk factors in children and adolescents. Journal of Pediatrics, 155, S6e15-26.
[18] Moran, A., Jacobs, D.R., Steinberger, J., Hong, C.-P., Prineas, R., Luepker, R. and Sinaiko, A.R. (1999) Insulin resistance during puberty: Results from clamp studies in 357 children. Diabetes, 48, 2039-2044.
http://dx.doi.org/10.2337/diabetes.48.10.2039
[19] Carroll, M.D., Kit, B.K., Lacher, D.A., Shero, S.T. and Mussolino, M.E. (2012) Trends in lipids and lipoproteins in US adults, 1988-2010. JAMA, 308, 1545-1554.
http://dx.doi.org/10.1001/jama.2012.13260
[20] Robinson, J.G., Bolland, L.L., McGovern, P.G., Folsom, A.R. (2001) A comparison of NCEP and absolute risk stratification methods for lipid-lowering therapy in middle-aged adults: The ARIC study. The ARIC Investigators. Preventive Cardiology, 4, 148-157.
http://dx.doi.org/10.1111/j.1520-037X.2001.00562.x
[21] Boden, W.E. (2000) High-density lipoprotein cholesterol as an independent risk factor in cardiovascular disease: Assessing the data from Framingham to the Veterans Affairs High-Density Lipoprotein Intervention Trial. American Journal of Cardiology, 86, 19L-22L.
http://dx.doi.org/10.1016/S0002-9149(00)01464-8
[22] Li, Z., Yang, R., Xu, G. and Xia, T. (2005) Serum lipid concentrations and prevalence of dyslipidemia in a large Professional population in Beijing. Clinical Chemistry, 51, 144-150.
http://dx.doi.org/10.1373/clinchem.2004.038646
[23] Bahar, A., Sevgican, U., Karademir, F. and Gocmen, I. (2003) Serum cholesterol, triglyceride, VLDL-c, LDL-c, and HDL-c levels in healthy children. The Tohoku Journal of Experimental Medicine, 201, 75-80.
http://dx.doi.org/10.1620/tjem.201.75
[24] National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. (2004) Pediatrics, 114, 555-576.
http://dx.doi.org/10.1542/peds.114.2.S2.555
[25] Cole, T.J., Bellizzi, M.C., Flegal, K.M. and Dietz, W.H. (2000) Establishing a standard definition for child over-weight and obesity worldwide: International survey. BMJ, 320, 1240-1243.
http://dx.doi.org/10.1136/bmj.320.7244.1240
[26] Jolliffe, C.J. and Janssen, I. (2006) Distribution of lipoproteins by age and gender in adolescents. Circulation, 114, 1056-1062.
http://dx.doi.org/10.1161/CIRCULATIONAHA.106.620864
[27] Webber, L.S., Srinivasan, S.R., Wattigney, W.A. and Berenson, G.S. (1991) Tracking of serum lipids and lipoproteins from childhood to adulthood: The Bogalusa Heart Study. American Journal of Epidemiology, 133, 884-899.
[28] Friedman, L.A., Morrison, J.A., Daniels, S.R., McCarthy, W.F. and Sprecher, D.L. (2006) Sensitivity and specifity of pediatric lipid determinations for adult lipid status: Findings from the Princeton Lipid Research Clinics Prevalence Program Follow-up Study. Pediatrics, 118, 165-172.
http://dx.doi.org/10.1542/peds.2005-2968

  
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