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Inverse relationship between glomerular hyperfiltration and C-peptide level in Type 1 diabetes

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DOI: 10.4236/jdm.2014.41009    3,593 Downloads   4,710 Views   Citations

ABSTRACT

Background: Increased glomerular filtration rate (GFR) commonly develops in early diabetes and is closely correlated with the development of diabetic nephropathy. Objective: The aim was to study the relationship between GFR, C-peptide level and other parameters at diagnosis of Type 1 diabetes. Methods: We determined GFR, Cpeptide level, glycated hemoglobin (HbA1c), body mass index (BMI) SDS and loss of weight at diagnosis of Type 1 diabetes in 495 children (231 females). Linear and multiple regression analysis was used to test for the associations between GFR and other parameters. Results: In the 495 patients, GFR median (interquartile range) was increased vs normal values (p = 0.0001). GFR was significantly negatively correlated with age (p < 0.001) and C-peptide level (p = 0.001), and positively correlated with weight loss (p = 0.02). The multiple regression analysis showed that age (p = 0.001) and C-peptide level (p = 0.05) were independently and negatively related to GFR. Conclusions: This study shows that, at onset of Type 1 diabetes, higher the GFR, younger the age and lower the C-peptide level are. The role of this hyperfiltration in the development of later nephropathy and the putative preventive effect of C-peptide administration need to be evaluated.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Messaaoui, A. , Tenoutasse, S. , Mélot, C. and Dorchy, H. (2014) Inverse relationship between glomerular hyperfiltration and C-peptide level in Type 1 diabetes. Journal of Diabetes Mellitus, 4, 50-53. doi: 10.4236/jdm.2014.41009.

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