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Purine nucleotides and their metabolites in patients with type 1 and 2 diabetes mellitus

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DOI: 10.4236/jbise.2014.71006    2,803 Downloads   4,783 Views   Citations


We measured the erythrocyte levels of principal nucleotides (ATP, ADP, AMP, GTP, GDP, GMP, IMP), nucleosides (Ado, Guo, Ino) and Hyp with HPLC. Purine concentrations were determined in the erythrocytes of 36 type 1 and 40 type 2 diabetic patients. The increased dephosphorylation of adenine and guanine nucleotides, indicated by increased Ado, Ino, Guo and Hyp concentrations as the products of purine nucleotide degradation, suggests serious energy metabolism disruptions in diabetes. An increase in AMP, GMP, IMP concentrations, as well as a decrease in AEC and GEC values, points to significant alterations in erythrocyte purine nucleotide concentration.

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The authors declare no conflicts of interest.

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Dudzinska, W. (2014) Purine nucleotides and their metabolites in patients with type 1 and 2 diabetes mellitus. Journal of Biomedical Science and Engineering, 7, 38-44. doi: 10.4236/jbise.2014.71006.


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