Share This Article:

CT Elastography: A Pilot Study via a New Endoscopic Tactile Sensor

Abstract Full-Text HTML XML Download Download as PDF (Size:1113KB) PP. 22-28
DOI: 10.4236/ojbiphy.2014.41004    2,796 Downloads   5,430 Views   Citations

ABSTRACT

Objective: To develop a CT elastography imaging system useful for part of the human body in which ultrasound
is not capable of reaching. The proposed system would measure CT modality through fusion of the stiffness mapping on the images by the tactile sensor system, improving precision of the endoscopic operation. Methods: We made some liver fibrosis phantoms of bovine skin gelatin with various densities as the target organ of the study. Using the tactile sensor system, which requires no compression during endoscopic operation, stiffness of each phantoms was measured. The resulting stiffness vs density curve was evaluated and translated to the stiffness vs CT number (Houndsfield Unit, HU) curve with a CT number vs density curve obtained by CT scan of the phantoms. A transformation formula can be deduced from these curves to the elasticity via CT number, which was confirmed in vitro with pig liver and in vivo CT scan data. Results: The stiffness and CT modality of each phantom was successfully measured and subjected to constant reduction. The CT value shows a linear relationship with the ROI values of the livers used. Conclusion: This paper reports method of supplementing stiffness information measured by a tactile sensor system, with a CT image for use with an endoscope. It is shown that CT number can be derived with a stiffness sensor and CT data in endoscopic surgery. From there results, we prove the possibility of measuring stiffness with CT and high resolution CT number.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

T. Sasaki, M. Haruta and S. Omata, "CT Elastography: A Pilot Study via a New Endoscopic Tactile Sensor," Open Journal of Biophysics, Vol. 4 No. 1, 2014, pp. 22-28. doi: 10.4236/ojbiphy.2014.41004.

References

[1] O. Sadao and C. E. Constantinou, “Constantinou Modeling of Micturition Characteristics Based on Prostatic Stiffness Modulation Induced Using Hormones and Adrenergic Antagonists,” IEEE Transactions on Biomedical Engineering, Vol. 42, No. 8, 1995, pp. 843-848. http://dx.doi.org/10.1109/10.398646
[2] V. Jalkanen, B. M. Andersson, A. Bergh, et al., “Prostate Tissue Stiffness as Measured with a Resonance Sensor System: A Study on Silicone and Human Prostate Tissue in Vitro,” Medical and Biological Engineering and Computing, Vol. 44, No. 7, 2006, pp. 593-603. http://dx.doi.org/10.1007/s11517-006-0069-6
[3] K. Miyaji, A. Furuse, J. Nakajima, et al., “The Stiffness of Lymph Nodes Containing Lung Carcinoma Metastases: a New Diagnostic Parameter Measured by a Tactile Sensor,” Cancer, Vol. 40, No. 8, 1995, pp. 1432-1436.
[4] T. Ohtsuka, A. Furuse, T. Kohno, et al., “Application of a New Tactile Sensor to Thoracoscopic Surgery: Experimental and Clinical Study,” The Annals of Thoracic Surgery, Vol. 60, No. 3, 1995, pp. 610-614. http://dx.doi.org/10.1016/0003-4975(95)00483-2
[5] M. K. Sugiura, S. Omata, S. Kaneko, et al., “Clinical and Biochemical Spectrum of Zinc Deficiency in Human Subjects,” Journal of the American College of Cardiology, Vol. 31 No. 5, 1998, pp. 1165-1173. http://dx.doi.org/10.1016/S0735-1097(98)00063-1
[6] L. Wexler, B. Brundage, et al., “Coronary Artery Calcification: Pathophysiology, Epidemiology, Imaging Methods, and Clinical Implications,” Circulation, Vol. 94, 1996, No. 5, pp. 1175-1192. http://dx.doi.org/10.1161/01.CIR.94.5.1175
[7] A. S. Agatston, W. R. Janowitz, et al., “Quantification of Coronary Artery Calcium Using Ultrafast Computed Tomography,” Journal of the American College of Cardiology, Vol. 15, No. 4, 1990, pp. 827-832.
[8] S. Omata and Y. Terunuma, “New Tactile Sensor Like the Human Hand and Its Applications,” Sensors and Actuators, Vol. 35, No. 1, 1992, pp. 9-15. http://dx.doi.org/10.1016/0924-4247(92)87002-X
[9] L. Sandrin, C. Fournier, et al., “Fibroscan ® in Hepatology: A Clinically-Validated Tool Using Vibration-Controlled Transient Elastography,” 2009 IEEE International Ultrasonics Symposium, Rome, 20-23 September 2009, pp. 1431-1434.
[10] R. Muthupillai, D. J. Lomas, P. J. Rossman, et al., “Magnetic Resonance Elastography by Direct Visualization of Propagating Acoustic Strain Waves,” Science, Vol. 269, No. 5232, 1995, pp. 1854-1857.
[11] U. Motosugi, et al., “Effects of Gadoxetic Acid on Liver Elasticity Measurement by Using Magnetic Resonance Elastography,” Magnetic Resonance Imaging, Vol. 30, No. 1, 2012, pp. 128-132. http://dx.doi.org/10.1016/j.mri.2011.08.005
[12] E. Ueno, E. Tohno, et al., “Dynamic Tests in Real-Time Breast Echography,” Ultrasound in Medicine & Biology, Vol. 14, Supplement 1, 1988, pp. 53-57. http://dx.doi.org/10.1016/0301-5629(88)90047-6
[13] A. Itoh, et al., “Breast Disease: Clinical Application of US Elastography for Diagnosis,” Radiology, Vol. 239, No. 2, 2006, pp. 341-350.
[14] T. Seki, et al., “Ultrasonically Guided Percutaneous Microwave Coagulation Therapy for Small Hepatic Cancer,” Cancer, Vol. 74, No. 3, 1994, pp. 817-825. http://dx.doi.org/10.1002/1097-0142(19940801)74:3<817::AID-CNCR2820740306>3.0.CO;2-8
[15] S. Rossi, M. Di Stasi, et al., “Percutaneous RF Interstitial Thermal Ablation in the Treatment of Small Hepatic Cancer,” Journal of the American College of Cardiology, Vol. 167, 1996, pp. 759-768.
[16] S. Rossi, F. Fornari and L. Buscarini, “Percutaneous Ultrasound-Guided Radiofrequency Electrocautery for the Treatment of Small Hepatocellular Carcinoma,” Journal of Vascular and Interventional Radiology, Vol. 8, 1993, pp. 97-103.
[17] C. Kubisch, S. Glaßer, et al., “Vessel Visualization with Volume Rendering,” Visualization in Medicine and Life Sciences II Mathematics and Visualization, Springer, Berlin, Heidelberg, 2012, pp. 109-132. http://dx.doi.org/10.1007/978-3-642-21608-4_7
[18] B. B. Frericks, F. C. Caldarone and B. Nashan, “3D CT Modeling of Hepatic Vessel Architecture and Volume Calculation in Living Donated Liver Transplantation,” European Radiology, Vol. 14, No. 2, 2004, pp. 326-333.
[19] J. D. Stefansic, A. J. Herline, Y. Shyr, et al., “Registration of Physical Space to Laparoscopic Image Space for Use in Minimally Invasive Hepatic Surgery,” IEEE Transactions on Medical Imaging, Vol. 19, No. 10, 2000, pp. 1012-1023. http://dx.doi.org/10.1109/42.887616
[20] R. M. Hochmuch, “Micropipette Aspiration of Living Cells,” Journal of Biomechanics, Vol. 33, No. 1, 2000, pp. 15-25.

  
comments powered by Disqus

Copyright © 2019 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.