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Degradation of nucleic acids and nucleotides in several conditions with perspectives of retrieval: A review

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DOI: 10.4236/abb.2014.51006    3,754 Downloads   5,511 Views  


Deoxyribonucleic acid (DNA) or oligonucleotides, can be modified in several ways as chemical degradation by electrophilic reaction, attack of radicals, hydrolytic deamination or oxidative damage caused by ionizing radiation. This work discussed these degradation mechanisms, determining the effects on these biomolecules. The actual knowledge about DNA damages only permits partial enzymatic repair treatments.

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The authors declare no conflicts of interest.

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Reyes, J. , Medina Orozco, L. , Jaramillo, M. , Romero, I. and Soriano, A. (2014) Degradation of nucleic acids and nucleotides in several conditions with perspectives of retrieval: A review. Advances in Bioscience and Biotechnology, 5, 36-39. doi: 10.4236/abb.2014.51006.


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