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Correlation between diabetes prevalence and subsequent cancer mortality in North Carolina counties

DOI: 10.4236/jdm.2014.41001    3,284 Downloads   5,324 Views   Citations

ABSTRACT

Worldwide, over 250 million people live with diabetes mellitus, a disease which has been described as an epidemic. While much is known about the cardiovascular risks associated with this condition, its association with cancer has been less appreciated at the population level. This study assessed the relationship between colo-rectal, breast and prostate cancer mortality, and diabetes prevalence measured years earlier at the county level in the 100 counties of North Carolina. Methods: County level data were obtained from the 2000 US Census, the Centers for Disease Control and Prevention, and the North Carolina State Center for Health Statistics. The 2004 diabetes prevalence data by county and county level mortality from 2005 to 2009 for colorectal, breast and prostate cancer mortality were analyzed descriptively. Then multivariate linear regression was carried out to evaluate the contribution of pre-existing diabetes prevalence to cancer mortality, controlling county level covariates. Results: Average North Carolina county level prevalence of diabetes mellitus in 2004 (9%) was higher than the average prevalence of diabetes nationally in 2004 (7%). Mortality rates for breast, colorectal and prostate cancers at the county level were also higher than those nationally. In multivariate analysis, county level 2005-2009 total cancer mortality as well as mortality from colon and prostate cancers (but not breast cancer) correlated with county level 2004 diabetes prevalence rates. Diabetes mellitus prevalence in 2004 explained 31%, 34% and 42% of the variance of mortality from prostate, colorectal and total cancers. Conclusions: These findings support the relationship between diabetes mellitus and cancer at the population level. Direct and indirect costs of cancer care in North Carolina in 2004 were $5.57 billion. Because diabetes explained 42% of the variance of total county level cancer mortality, prevention and control of diabetes could save the state over $2 billion.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Spangler, J. and Kirk, J. (2014) Correlation between diabetes prevalence and subsequent cancer mortality in North Carolina counties. Journal of Diabetes Mellitus, 4, 1-5. doi: 10.4236/jdm.2014.41001.

References

[1] Vigneri, P., Frasca, F., Sciacca, L., Pandini, G. and Vigneri, R. (2009) Diabetes and cancer. Endocrine-Related Cancer, 16, 1103-1123. http://dx.doi.org/10.1677/ERC-09-0087
[2] Wild, S., Roglic, G., Green, A., Sicree, R. and King, H. (2004) Global prevalence of diabetes. Diabetes Care, 27, 1047-1053. http://dx.doi.org/10.2337/diacare.27.5.1047
[3] Irizarry, L., Li, Q.E., Duncan, I., et al. (2013) Effects of Cancer Comorbidity on Disease Management: Making the Case for Diabetes Education (A Report from the SOAR Program). Population Health Management, 16, 53-57. http://dx.doi.org/10.1089/pop.2012.0028
[4] Giovannucci, D., Harlan, D.M., Archer, M.C., et al. (2010). Diabetes and Cancer: A Consensus Report. Diabetes Care, 33, 1674-1685. http://dx.doi.org/10.2337/dc10-0666
[5] El-Serag, H.B., Hampel, H. and Javadi, F. (2006) The association between diabetes and hepatocellular carcinoma: A systematic review of epidemiologic evidence. Clinical Gastroenterology and Hepatology, 4, 369-380. http://dx.doi.org/10.1016/j.cgh.2005.12.007
[6] Huxley, R., Ansary-Moghaddam, A., Berrington de Gonzalez, A., Barzi, F. and Woodward, M. (2005) Type-II diabetes and pancreatic cancer: A meta-analysis of 36 studies. British Journal of Cancer, 92, 2076-2083. http://dx.doi.org/10.1038/sj.bjc.6602619
[7] Lindblad, P., Chow, W.H., Chan, J., Bergstrom, A., Wolk, A., Gridley, G., McLaughlin, J.K., Nyren, O., Adami, H.O. (1999) The role of diabetes mellitus in the aetiology of renal cell cancer. Diabetologia, 42, 107-112. http://dx.doi.org/10.1007/s001250051122
[8] Washio, M., Mori, M., Khan, M., Sakauchi, F., Watanabe, Y., Ozasa, K., Hayashi, K., Miki, T., Nakao, M., Mikami, K. et al. (2007) Diabetes mellitus and kidney cancer risk: the results of Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study). International Journal of Urology, 14, 393-397. http://dx.doi.org/10.1111/j.1442-2042.2007.01744.x
[9] Friberg, E., Orsini, N., Mantzoros, C.S. and Wolk, A. (2007) Diabetes mellitus and risk of endometrial cancer: A meta-analysis. Diabetologia, 50, 1365-1374. http://dx.doi.org/10.1007/s00125-007-0681-5
[10] Larsson, S.C., Orsini, N. and Wolk, A. (2005) Diabetes mellitus and risk of colorectal cancer: A meta-analysis. Journal of the National Cancer Institute, 97, 1679-1687. http://dx.doi.org/10.1093/ jnci/dji375
[11] Larsson, S.C., Orsini, N., Brismar, K. and Wolk, A. (2006) Diabetes mellitus and risk of bladder cancer: A metaanalysis. Diabetologia, 49, 2819-2823. http://dx.doi.org/10.1007/s00125-006-0468-0
[12] Larsson, S.C., Mantzoros, C.S. and Wolk, A. (2007) Diabetes mellitus and risk of breast cancer: A meta-analysis. International Journal of Cancer, 121, 856-862. http://dx.doi.org/10.1002/ijc.22717
[13] Mitri, J., Castillo, J. and Pittas, A.G. (2008) Diabetes and risk of non-Hodgkin’s lymphoma: A meta-analysis of observational studies. Diabetes Care, 31, 2391-2397. http://dx.doi.org/10.2337/dc08-1034
[14] Kasper, J.S. and Giovannucci, E. (2006). A meta-analysis of diabetes mellitus and the risk of prostate cancer. Cancer Epidemiology, Biomarkers and Prevention, 15, 2056-2062. http://dx.doi.org/10. 1158/1055-9965.EPI-06-0410
[15] American Diabetes Association (2013) Diabetes and Cancer. http://www.diabetes.org/diabetes-basics/prevention/checkup-america/diabetes-and-cancer.html
[16] Manjinder, S., Sandhu, M.S., Dunger, D.B. and Giovannucci, E.L. (2002) Insulin, Insulin-Like Growth Factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer. Journal of the National Cancer Institute, 94, 972-980. http://dx.doi.org/10.1093/jnci/94.13.972
[17] Spangler, J.G. (2012) Diabetes mortality and environmental heavy metals in North Carolina counties: An ecological study. Journal of Diabetes Mellitus, 2, 369-372. http://dx.doi.org/10.4236/jdm. 2012.24057
[18] Center for Disease Control and Prevention (2013) Diabetes Data and Trends. http://apps.nccd. cdc.gov/ddtstrs/default.aspx
[19] (2013) North Carolina State Center for Health Statistics. http://www.schs.state.nc.us/schs/CCR/ mortality.html
[20] Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J. and Thun, M.J. (2009) Cancer Statistics. CA: A Cancer Journal for Clinicians, 59, 225-249. http://dx.doi.org/10.3322/caac.20006
[21] CDC (2013) US Cancer Statistics: An Interactive Atlas. http://apps.nccd.cdc.gov/DCPC_INCA/ DCPC_INCA.aspx
[22] Dayal, H., Chiu, C.Y., Sharrar, R., et al. (1984) Ecologic correlates of cancer mortality patterns in an industrialized urban population. Journal of the National Cancer Institute, 73, 565-574.
[23] Stocks, P. (1960) On the relations between atmospheric pollution in urban and rural localities and mortality from cancer, bronchitis and pneumonia, with particular reference to 3,4-benzopyrene, beryllium, molybdenum, vanadium and arsenic. British Journal of Cancer, 14, 397-418.
http://dx.doi.org/10.1038/bjc.1960.45
[24] Jemal, A., Center, M.M., DeSantis, C. and Ward, E.M. (2010) Global Patterns of Cancer Incidence and Mortality Rates and Trends. Cancer Epidemiology, Biomarkers & Prevention, 19, 1893-1907.
http://dx.doi.org/10.1158/1055-9965.EPI-10-0437
[25] Battle, L.A., Knight, K., Gaines, M., Jayathirtha, C. and Williams, D. (2004) North Carolina Cancer Facts and Figures 2004. North Carolina Central Cancer Registry: Raleigh, North Carolina.
[26] Hellquist, B.N., Duffy, S.W., Abdsaleh, S., et al. (2011) Effectiveness of population-based service screening with mammography for women ages 40 to 49 years. Cancer, 117, 714-722.
http://dx.doi.org/10.1002/cncr.25650
[27] Kalager, M., Zelen, M., Langmark, F. and Adami, H.O. (2010) Effect of Screening Mammography on BreastCancer Mortality in Norway. The New England Journal of Medicine, 363, 1203-1210. http://dx.doi.org/10.1056/NEJMoa1000727

  
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