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Seasonal modulation of the C-type lectin MGL on human DCs

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DOI: 10.4236/oji.2013.34027    2,901 Downloads   4,439 Views   Citations

ABSTRACT

The C-type lectin MGL is a pathogen recognition receptor, expressed by dendritic cells (DCs) and macrophages (Mfs), able to bind GalNAc (Tn) carrying structures. This receptor also recognized Tn-TAAs that were internalized, processed and presented by DCs to T cells and it acted as an adjuvant on DCs, highlighting its possible application in anti-cancer vaccination. In this work, we found that this receptor present a seasonal modulation: its expression is higher in winter rather than in summer. The percentage of MGL+ donors displayed a negative trend that dropped to 33% during the summer and increased up to 100% in winter. This modulation could be also ascribed to the circa-annual variation of glucocorticoids, in fact MGL is up-regulated in presence of dexamethasone in vitro. The seasonal variation of this receptor could be an important point in the field of tumor vaccination strategies.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Zizzari, I. , Napoletano, C. , Rughetti, A. , Rahimi, H. and Nuti, M. (2013) Seasonal modulation of the C-type lectin MGL on human DCs. Open Journal of Immunology, 3, 218-220. doi: 10.4236/oji.2013.34027.

References

[1] van Vliet, S.J., García-Vallejo, J.J. and van Kooyk, Y. (2008) Dendritic cells and C-type lectin receptors: Coupling innate to adaptive immune responses. Immunology and Cell Biology, 86, 580-587. http://dx.doi.org/10.1038/icb.2008.55
[2] Zelensky, A. N. and Gready, J. E. (2005) The C-type lectin-like domain superfamily. FEBS Journal, 272, 6179-6217. http://dx.doi.org/10.1111/j.1742-4658.2005.05031.x
[3] van Vliet, S.J., van Liempt, E., Saeland, E., Aarnoudse, C.A., Appelmelk, B., Irimura, T., Geijtenbeek, T.B., Blixt, O., Alvarez, R., van Die, I. and van Kooyk, Y. (2005) Carbohydrate profiling reveals a distinctive role for the C-type lectin MGL in the recognition of helminth parasites and tumor antigens by dendritic cells. International Immunology, 17, 661-669. http://dx.doi.org/10.1093/intimm/dxh246
[4] Napoletano, C., Zizzari, I.G., Rughetti, A., Rahimi, H., Irimura, T., Clausen, H., Wandall, H.H., Belleudi, F., Bellati, F., Pierelli, L., Frati, L. and Nuti, M. (2012) Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation. European Journal of Immunology, 42, 936-945. http://dx.doi.org/10.1002/eji.201142086
[5] Napoletano, C., Rughetti, A., Tarp, M.P.A., Coleman, J., Bennett, E.P., Picco, G., Sale, P., Denda-Nagai, K., Irimura, T., Mandel, U., Clausen, H., Frati, L., Taylor-Papadimitriou, J., Burchell, J. and Nuti, M. (2007) Tumor-associated Tn-MUC1 glycoform is internalized through the macrophage galactose-type C-type lectin and delivered to the HLA class I and II compartments in dendritic cells. Cancer Research, 67, 8358-8367. http://dx.doi.org/10.1158/0008-5472.CAN-07-1035
[6] Yoshida, K., Baba, K., Yamamoto, N. and Tazaki, K (1994) Cloning of a lectin cDNA and seasonal changes in levels of the lectin and its mRNA in the inner bark of Robinia pseudoacacia. Plant Molecular Biology, 25, 1010-1017. http://dx.doi.org/10.1007/BF00028879
[7] van Vliet, S.J., van Liempt, E., Geijtenbeek, T.B. and van Kooyk, Y. (2006) Differential regulation of C-type lectin expression on tolerogenic dendritic cell subsets. Immunobiology, 211, 577-585. http://dx.doi.org/10.1016/j.imbio.2006.05.022
[8] Lévi, F.A., Canon, C., Touitou, Y., Reinberg, A. and Mathé, G. (1988) Seasonal modulation of the circadian time structure of circulating T and natural killer lymphocyte subsets from healthy subjects. Journal of Clinical Investigation, 81, 407-413. http://dx.doi.org/10.1172/JCI113333
[9] Rea, D., van Kooten, C., van Meijgaarden, K.E., Ottenhoff, T.H., Melief, C.J. and Offringa, R. (2000) Glucocorticoids transform CD40-triggering of dendritic cells into an alternative activation pathway resulting in antigen-presenting cells that secrete IL-10. Blood, 95, 3162-3167.
[10] Moser, M., De Smedt, T., Sornasse, T., Tielemans, F., Chentoufi, A.A., Muraille, E., Van Mechelen, M., Urbain, J. and Leo, O. (1995) Glucocorticoids down-regulate dendritic cell function in vitro and in vivo. European Journal of Immunology, 25, 2818-2824. http://dx.doi.org/10.1002/eji.1830251016
[11] Walker, B.R., Best, R., Noon, J.P., Watt, G.C. and Webb, D.J. (1997) Seasonal variation in glucocorticoid activity in healthy men. The Journal of Clinical Endocrinology & Metabolism, 82, 4015-4019. http://dx.doi.org/10.1210/jc.82.12.4015
[12] Khoo, A.L., Chai, L.Y., Koenen, H.J., Sweep, F.C., Joosten, I., Netea, M.G. and van der Ven A.J. (2011) Regulation of cytokine responses by seasonality of vitamin D status in healthy individuals. Clinical & Experimental Immunology, 164, 72-79. http://dx.doi.org/10.1111/j.1365-2249.2010.04315.x

  
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