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Idiopathic Intracranial Hypertension in Sickle Cell Disease: A Paediatric Case Report

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DOI: 10.4236/nm.2013.44033    3,997 Downloads   5,347 Views  


In this article, we present the case of a 12-year-old girl with sickle cell disease (SCD), who presented with the severe headache. She had bilateral 6th cranial nerve palsy and papilloedema. The common sickle cell-related vascular causes of headache were ruled out by neuro-imaging. She then had a lumbar puncture and was diagnosed with idiopathic intracranial hypertension (IIH). This case demonstrates that IIH can affect younger children with SCD and should form a part of differential diagnosis when investigating causes of headache in SCD.

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The authors declare no conflicts of interest.

Cite this paper

B. Gowda and S. Sahi, "Idiopathic Intracranial Hypertension in Sickle Cell Disease: A Paediatric Case Report," Neuroscience and Medicine, Vol. 4 No. 4, 2013, pp. 215-216. doi: 10.4236/nm.2013.44033.


[1] I. Abu-Arefeh and G. Russell, “Prevalence of Headache and Migraine in School Children,” British Medical Journal, Vol. 309, 1994, pp. 765-769.
[2] A. E. Niebanck, A. N. Pollock, K. Smith-Whitley, L. J. Raffini, R. A. Zimmerman, K. Ohene-Frempong and J. L. Kwiatowski, “Headache in Children with Sickle Cell Disease: Prevalence and Associated Factors,” Journal of Pediatrics, Vol. 151, No. 1, 2007, pp. 67-72.
[3] W. E. Dandy, “Intracranial Pressure without Brain Tumor,” Annals of Surgery, Vol. 106, No. 4, 1937, pp. 492-513.
[4] D. Friedman and D. Jacobson, “Diagnostic Criteria for Idiopathic Intracranial Hypertension,” Neurology, Vol. 59, No. 10, 2002, pp. 1492-1495.
[5] R. A. Avery, S. S. Shah, D. J. Licht, J. A. Huh, J. Boswinkel, M. D. Ruppe, A. Chew, R. D. Mistry and G. T. Liu, “Reference Range for Cerebrospinal Fluid Opening Pressure in Children,” The New England Journal of Medicine, Vol. 363, 2010, Article ID. 891-9-893
[6] E. Thomas, “Recurrent BIH Associated with Hemoglobin SC Disease in Pregnancy,” Obstetrics & Gynecology, Vol. 67, Suppl. 3, 1986, pp. 7S-9S.
[7] M. Henry, M. C. Driscoll, M. Miller, T. Chang and C. P. Minniti, “Pseudotumor Cerebri in Children with Sickle Cell Disease: A Case Series,” Pediatrics, Vol. 113, No. 3, 2004, pp. 265-269.
[8] L. Segal and M. Discepola, “Idiopathic Intracranial Hypertension and Sickle Cell Disease: Two Case Reports,” Canadian Journal of Ophthalmology, Vol. 40, No. 6, 2005, pp. 764-767.
[9] D. Soler, T. Cox, P. Bullock, D. M. Calver and R. O. Robinson, “Diagnosis and Management of Benign Intracranial Hypertension,” Archives of Disease in Childhood, Vol. 78, No. 1, 1998, pp. 89-94.
[10] J. O. Donaldson, “Pathogenesis of Pseudotumour Cerebri Syndromes,” Neurology, Vol. 31, No. 7, 1981, pp. 877-880.

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