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The Expression of NF-κB in the Glomerulus of Hyperlipidemia Rats

DOI: 10.4236/ijcm.2011.21001    3,983 Downloads   7,068 Views  

ABSTRACT

Background: The present study was to explore the underlying mechanism of the nuclear factor-kappa B (NF-κB) and the level of monocyte chemoattractant protein-1 (MCP-1) in hyperlipidemia rats. Methods: Rats were given with high fat diet and vitamin D3 by intragastric administration. After four weeks, the level of the plasma cholesterol, low density lipoprotein cholesterol (LDLC), MCP-1 and NF-κB were detected by immunohistochemical method and enzyme linked immunosorbent assay (ELISA). Results: The levels of the plasma cholesterol and LDLC were higher than that of the control group. A significant in-crease for the expressions of MCP-1 and NF-κB was observed. Conclusion: This indi-cated that the activation of NF-κB could play a crucial role in glomerulus of hyperlipidemia rats.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

X. Li, R. Yan and J. Peng, "The Expression of NF-κB in the Glomerulus of Hyperlipidemia Rats," International Journal of Clinical Medicine, Vol. 2 No. 1, 2011, pp. 1-4. doi: 10.4236/ijcm.2011.21001.

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