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Spot urine protein/creatinine ratio—A quick and accurate method for diagnosis of pre-eclampsia

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DOI: 10.4236/ojog.2013.38109    8,282 Downloads   13,001 Views   Citations

ABSTRACT

Objective(s):To assess the diagnostic accuracy of spot urine protein-creatinine (P/C) ratio and its compareson with 24-hour urine proteinuria for predicting eclampsia. Method(s): Spot urine P/C ratio was determined in a mid-stream urine sample, and the 24-hour urine protein was measured. The correlation between the spot P/C ratio and 24-hour urine protein amount was done. Logistic regression analysis and ROC curve analysis have been used to analyse data. Result(s): There was a strong correlation between the spot P/C ratio and 24-hour urine protein excretion (pearson’s correlation coefficient r = 0.71; P < 0.0001). The optimal spot P/C ratio cutoff point was 0.25, for 300 mg/24 h of protein excretion, with sensitivity and specificity of 69% and 75% respectively. Conclusion(s): Spot urine P/C ratio is a quick and reliable tool which can be used as an alternative method for evaluation of proteinuria for diagnosis of pre-eclampsia.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Sharma, A. , Kiran, P. and Ajai, B. (2013) Spot urine protein/creatinine ratio—A quick and accurate method for diagnosis of pre-eclampsia. Open Journal of Obstetrics and Gynecology, 3, 609-612. doi: 10.4236/ojog.2013.38109.

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