Share This Article:

The effect of transcorneal electrical stimulation in visual acuity: Retinitis pigmentosa

DOI: 10.4236/jbise.2013.610A2001    2,946 Downloads   5,435 Views   Citations

ABSTRACT

Transcorneal Electrical Stimulation (TES) was applied to a group of volunteer patients suffering from Retinitis Pigmentosa (RP), in order to investigate the effect of TES in Visual Acuity (VA). 28 partial blind patients with diagnosis of classic RP, Usher syndrome I and/or II were stimulated transcornealy, during a period of 52 weeks using a non conventional waveform, only in the lowest visually capable eye. The proposed waveform has been modeled from the natural response of human retina and delivered by means of an adaptive generator designed and built for tissue stimulation. Statistical results show the improvement of average VA or at least the contention of the disease natural progress. Categorized analysis of results indicates the same effect that if the age of patients, time since diagnosis and genetic disorder variation (classic RP, Usher syndrome I and/or II) are considered, in this case clinical and electrophysiological follow-up parameters were statistically analyzed in order to know the effect of TES. General results yield an improvement of 48.15% in the average of VA for stimulated eyes against an average degreasing of -8.06% in the same scale, with respect to their basal condition before the start of the experiment.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Robles-Camarillo, D. , Niño-de-Rivera, L. , López-Miranda, J. , Gil-Carrasco, F. and Quiroz-Mercado, H. (2013) The effect of transcorneal electrical stimulation in visual acuity: Retinitis pigmentosa. Journal of Biomedical Science and Engineering, 6, 1-7. doi: 10.4236/jbise.2013.610A2001.

References

[1] Horsager, A. (2009) Prosthetic visual perception: Retinal electrical stimulation in blind human patients. Ph.D. Thesis, University of Southern California, Los Angeles.
[2] Inomata, K., Shinoda, K., Ohde, H., Tsunoda, K., Hanazono, G., Kimura, I., Yuzawa, M., Tsubota, K. and Miyake, Y. (2007) Transcorneal electrical stimulation of retina to treat longstanding retinal artery occlusion. Graefe’s Archive for Clinical and Experimental Ophthalmology, 245, 1773-1780.
http://dx.doi.org/10.1007/s00417-007-0610-9
[3] Schatz, A., Rock, T., Naycheva, L., Willmann, G., Wilhelm, B., Peters, T., Bartz-Schmidt, K., Zrenner, E., Messias, A. and Gekeler, F. (2011), Transcorneal electrical stimulation for patients with retinitis pigmentosa-A prospective, randomized, sham-controlled exploratory study.
Investigative Ophthalmology & Visual Science, 10, 6932
[4] Morimoto, T., Miyoshi, T., Sawai, H. and Fujikado, T. (2010) Optimal parameters of transcorneal electrical stimulation (TES) to be neuroprotective of axotomized RGCs in adult rats. Experimental Eye Research, 90, 285e291.
[5] Usui, S., Kamiyama, Y., Ogura, T., Ishihara, A. and Hamada, T. (1997) Physiological engineering model of the outer retina. Proceedings of the International Conference on Neural Networks, 4, 2309-2314.
[6] Hammond, C. (2001) Cellular and molecular neurobiology. 2nd Edition, Academic Press, Paris.
[7] López-Miranda, M.J., Robles-Camarillo, D., Nino-deRivera, L. and Quiroz-Mercado, H. (2010) Transcorneal electrical stimulation in patients with retinitis pigmentosa. Proceedings of the Annual Meeting 2010, Meeting Abstracts, 51, 1356.
[8] Robles-Camarillo, D., Nino-de-Rivera, L., Quiroz-Mercado, H. and López-Miranda, M.J. (2006) Distributed retinal response model based on adaptive system. Proceedings of the BIOSIGNAL 2006, Brno, 352-354.
[9] Robles-Camarillo, D., Nino-de-Rivera, L., Quiroz-Mercado, H. and López-Miranda, M.J. (2008) Waveform generator system to transcorneal stimulation based on a digital adaptive model. 5th International Conference on Electrical Engineering, Computing Science and Automatic Control, 12-14 November 2008, 120-124.
[10] Robles-Camarillo, D., Nino-de-Rivera, L., Quiroz-Mercado, H. and López-Miranda, M.J. (2009) Portable transcorneal electrical stimulator system, applied on electrotherapy for low vision patients. 52nd IEEE International Midwest Symposium on Circuits and Systems, 2-5 August 2009, 1-4.
[11] Marmor, M., Fulton, A., Holder, G., Miyake, Y., Brigell, M. and Bach, M. (2009). ISCEV Standard for full-field clinical electroretinography (2008 update). Documenta Ophthalmologica, 118, 69-77.
http://dx.doi.org/10.1007/s10633-008-9155-4
[12] Hood, D., Bach, M., Brigell, M., Keating, D., Kondo, M., Lyons, J., Marmor, M., McCulloch D. and PalmowskiWolfe A. (2011) ISCEV standard for clinical multifocal electroretinography (mfERG) (2011 edition). Documenta Ophthalmologica, 124, 1-13.
http://dx.doi.org/10.1007/s10633-011-9296-8

  
comments powered by Disqus

Copyright © 2018 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.