Share This Article:

Case Report: An Unusual Osseous Lesion

Abstract Full-Text HTML Download Download as PDF (Size:205KB) PP. 170-173
DOI: 10.4236/ojpathology.2013.34031    2,967 Downloads   4,515 Views  

ABSTRACT

The intraosseous benign notochordal cell tumor (BNCT) is an intravertebral lesion derived from notochordal tissue. The notochord develops in humans during the third week of embryonic life and persists in adults as the nucleus pulposus of the vertebral disks. The most common locations of such tumors are the saccrococcygeal region and the skull base. Most tumors are asymptomatic and small. Magnetic resonance imaging is useful in their detection and precise localization. Histologically, these lesions consist of sheets of adipocyte-like vacuolated or less vacuolated eosinophilic tumor cells with eccentrically located round nuclei without myxoid matrix. The tumor cells express the epithelial markers, vimentin and S100 protein. Main differential diagnosis is chordoma. Intraosseous BNCT do not require any surgical management and should be recognized by pathologists to prevent unnecessary radical surgery. These lesions should be followed-up with conventional MRI.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

B. Riviere, T. Rousset, L. Bauchet, N. Champfleur, V. Szablewski, V. Costes and V. Rigau, "Case Report: An Unusual Osseous Lesion," Open Journal of Pathology, Vol. 3 No. 4, 2013, pp. 170-173. doi: 10.4236/ojpathology.2013.34031.

References

[1] H. Amer and M. Hameed, “Intraosseous Benign Notochordal Cell Tumor,” Archives of Pathology & Laboratory Medicine, Vol. 134, No. 2, 2010, pp. 283-288.
[2] W. L. Wang, J. H. Abramson, A. Ganguly and A. E. Rosenberg, “The Surgical Pathology of Notochordal Remnants in Adult Intervertebral Disks: A Report of 3 Cases,” American Journal of Surgical Pathology, Vol. 32, No. 8, 2008, pp. 1123-1129. http://dx.doi.org/10.1097/PAS.0b013e3181757954
[3] A. Chauvel, F. Taillat, O. Gille, et al., “Giant Vertebral Notochordal Rest: A Newentity Distinct from Chordoma,” Histopathology, Vol. 47, No. 6, 2005, pp. 646-649. http://dx.doi.org/10.1111/j.1365-2559.2005.02168.x
[4] F. Mehnert, R. Beschorner, W. Küker, U. Hahn and T. Nagele, “Retroclival Ecchordosisphysaliphora: MR Imaging and Review of the Literature,” American Journal of Neuroradiology, Vol. 25, No. 10, 2004, pp. 1851-1855.
[5] H. Luschka, “Die Altersveraenderungen der Zwischenwirbelknorpel,” Virchows Archiv A, Pathological Anatomy and Histology, Vol. 9, No. 3, 1856, pp. 311-327. http://dx.doi.org/10.1007/BF01879395
[6] R. Virchow, “Untersuchungen ueber die Entwicklung des Schaedelgrundes,” G. Rimer, Berlin, 1857, p. 47.
[7] H. Ribbert and H. Steiner, “Uber die Ecchondrosis Physalifora Sphenooccipitalis,” Zentralbl Allg Pathol Anat, Vol. 5, 1894, pp. 457-461.
[8] T. Yamaguchi, S. Suzuki, H. Ishiiwa and Y. Ueda, “Intraosseous Benign Notochordalcell Tumours: Overlooked Precursors of Classic Chordomas?” Histopathology, Vol. 44, No. 6, 2004, pp. 597-602. http://dx.doi.org/10.1111/j.1365-2559.2004.01877.x
[9] T. Yamaguchi, S. Suzuki, H. Ishiiwa, K. Shimizu and Y. Ueda, “Benign Notochordalcell Tumors: A Comparative Histological Study of Benign Notochordal Cell Tumors, Classic Chordomas, and Notochordal Vestiges of Fetal Intervertebral Disks,” American Journal of Surgical Pathology, Vol. 28, No. 6, 2004, pp. 756-761. http://dx.doi.org/10.1097/01.pas.0000126058.18669.5d
[10] T. Yamaguchi, J. Iwata, S. Sugihara, et al., “Distinguishing Benign Notochordalcell Tumors from Vertebral Chordoma,” Skeletal Radiology, Vol. 37, No. 4, 2008, pp. 291-299. http://dx.doi.org/10.
1007/s00256-007-0435-y
[11] V. Deshpande, G. P. Nielsen, D. I. Rosenthal and A. E. Rosenberg, “Intraosseous Benign Notochord Cell Tumors (BNCT): Further Evidence Supporting a Relationship Tochordoma,” American Journal of Surgical Pathology, Vol. 31, No. 10, 2007, pp. 1573-1577. http://dx.doi.org/10.1097/PAS.0b013e318
05c9967
[12] T. Nishiguchi, K. Mochizuki, M. Ohsawa, T. Inoue, K. Kageyama, A. Suzuki, T. Takami and Y. Miki, “Differentiating Benign Notochordal Cell Tumors from Chordomas: Radiographic Features on MRI, CT, and Tomography,” American Journal of Roentgenology, Vol. 196, No. 3, 2011, pp. 644-650. http://dx.doi.org/10.2214/AJR.10.4460
[13] S. H. Ng, S. F. Ko, Y. L. Wan, L. M. Tang and Y. S. Ho, “Cervical Ecchordosis Physaliphora: CT and MR Features,” British Journal of Radiology, Vol. 71, No. 843, 1998, pp. 329-331.
[14] Y. Kikuchi, T. Yamaguchi, H. Kishi, K. Azuhata, G. Kimizuka, K. Hiroshima and Y. Nakatani, “Pulmonary Tumor with Notochordal Differentiation: Report of Two Cases Suggestive of Benign Notochordal Cell Tumor of Extraosseous Origin,” American Journal of Surgical Pathology, Vol. 35, No. 8, 2011, pp. 1158-1164.

  
comments powered by Disqus

Copyright © 2018 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.