Share This Article:

The effect of administrating hyoscine bromide on pregnancy rate before embryo transfer in ART cycles

Abstract Full-Text HTML Download Download as PDF (Size:218KB) PP. 586-592
DOI: 10.4236/ojog.2013.37105    3,589 Downloads   5,312 Views   Citations

ABSTRACT

Assisted reproductive technology methods i.e., IVF and ICSI were extensively used for treatment of infertility. Although, these methods have many advantages but ART pregnancy rate remains low (30% - 35%). It seems that uterine peristalsis occurred after rhCG administration in turn resulting to impair implantation of the transferred embryos. Therefore this study was conducted to possess of whether hyoscine bromide can effectively alleviate uterine contraction and then have any effect on the reproductive outcome. Healthy women who underwent IVF or ICSI cycles (n = 142) were randomly assigned to one of two groups at the start of the cycle. Group control (n = 71) without applied hyoscine and group experiment (n = 71) applied hyoscine (25 mg). Controlled ovarian hyperstimulation was induced with follicle stimulating hormone (FSH). Sperm preparation and ovarian puncture for in vitro maturation and fertilization (IVF) of oocyte were carried out for 42 hours after rhCG injection. Two weeks after rhCG injection, bhCG pregnancy test to determine pregnancy outcome in both groups was done and the outcome results, along with other information were recorded separately. The pregnancy rate in experimental group was significantly higher than that of control group. when all of the cycles with or without giving 25 mg of hyosine were stratified by the mean total follicles (more/less than 2 follicles) and embryos (more/less than25 kg/m2), the Patients’ age, the quality grade of embryos and infertility duration (more/less than 5 years), the reproductive outcome, in overall, in the subjects with more than 10 oocytes, 5 embryos, more than quality A and B grades of embryos, less than 35 years age and also less than 5 years infertility duration was more pronounced than the other patients. But the other parameter was not affected by the reproductive outcome. Clinical or statistical improvement of the reproductive outcome could be demonstrated in the hyosine treated group especially with increasing the mean total follicles, embryo, quality of embryo in women with low age and infertility duration. However, further well-designed studies are essential to offer a final conclusion.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Zargar, M. , Kajbaf, S. and Hemadi, M. (2013) The effect of administrating hyoscine bromide on pregnancy rate before embryo transfer in ART cycles. Open Journal of Obstetrics and Gynecology, 3, 586-592. doi: 10.4236/ojog.2013.37105.

References

[1] Moramezi, F., Barati, M., Mohammadjafari, R., Barati, S. and Hemadi, M. (2012) Effect of hysteroscopy before intra uterine insemination on fertility in infertile couples. Pakistan Journal of Biological Sciences, 15, 942-946. doi:10.3923/pjbs.2012.942.946
[2] Speroff, L. and Fritz, M.A. (2011) Clinical gynecologic endocrinology and infertility. 8th Edition, Lippincott Williams & Wilkins, Philadelphia, 143-148, 501-518, 1150-1151
[3] Hourvitz, A. (2006) Role of embryo quality in predicting early pregnancy loss following assisted reproductive technology. Reproductive BioMedicine Online, 13, 504-509. doi:10.1016/S1472-6483(10)60637-2
[4] Bahceci, M. and Ulug, U. (2005) Does underlying infertility aetiology impact on first trimester miscarriage rate following ICSI? A preliminary report from 1244 singleton gestations. Human Reproduction, 20, 717-721. doi:10.1093/humrep/deh681
[5] Fanchin, R. and Ayoubi, J.M. (2009) Uterine dynamics: Impact on the human reproduction process. Reproductive BioMedicine Online, 18, 57-62. doi:10.1016/S1472-6483(10)60450-6
[6] Morizaki, N., Morizaki, J., Hayashi, R.H. and Garfield, R.E. (1989) A functional and structural study of the innervation of the human uterus. American Journal of Obstetrics & Gynecology, 160, 218-228. doi:10.1016/0002-9378(89)90126-9
[7] Nakai, A., Togashi, K., Kosaka, K., Kido, A., Kataoka, M., Koyama, T. and Fujii, S. (2008) Do anticholinergic agents suppress uterine peristalsis and sporadic myometrial contractions at cine MR imaging? Radiology, 246, 489-497. doi:10.1148/radiol.2461062091
[8] Kido, A., Togashi, K., Hatayama, H., Nakayama, T., Yamamoto, A., Kataoka, M. and Tulandi, T. (2009) Uterine peristalsis in women with repeated ART failures: possible therapeutic effect of hyoscine bromide. Journal of Obstetrics and Gynaecology Canada, 31, 732-735.
[9] Lesny, P. and Killick, S.R. (2004) The junctional zone of the uterus and its contractions. BJOG, 111, 1182-1189. doi:10.1111/j.1471-0528.2004.00350.x
[10] Marikinti, K. and Brinsden, P.R. (2005) The presence of blood in the transfer catheter negatively influences outcome at embryo transfer. Human Reproduction, 20, 2029-2030. doi:10.1093/ humrep/deh812
[11] Sohrabvand, F., Haghollahi, F., Maasomi, M., Asgarpoor, L., Shariat, M. and Hamedani, M. (2009) The effect of administrating indomethacin or hyoscine before embryo transfer on ART outcome (a pilot study). Iranian Journal of Reproductive Medicine, 7, 169-173.
[12] Pierzynski, P., Reinheimer, T.M. and Kuczynski, W. (2007) Oxytocin antagonists may improve infertility treatment. Fertility and Sterility, 88, 213.e19-213.e22.
[13] Grimes, D.A., Hubacher, D., Lopez, L.M. and Schulz, K.F. (2006) Nonsteroidal anti-inflammatory drugs for heavy bleeding or pain associated with intrauterine-device use. Cochrane Database of Systematic Reviews, 18, CD006034.
[14] Rhodes, T.L., McCoy, T.P., Higdon, H.L. and Boone, W.R. (2005) Factors affecting assisted reproductive technology (ART) pregnancy rates: A multivariate analysis. Journal of Assisted Reproduction and Genetics, 22, 335-346. doi:10.1007/s10815-005-6794-1
[15] Warburton, D., Kline, J., Stein, Z. and Strobino, B. (1986) Cytogenetic abnormalities in spontaneous abortions of recognized conceptions. In: Porter, I.H., Hatcher, N. and Willey, A.M., Eds., Perinatal Genetics, Academic Press, New York City, 23-40.
[16] Warburton, D. (1987) Reproductive loss: How much is preventable? The New England Journal of Medicine, 316, 158. doi:10.1056/NEJM198701153160308
[17] Feldberg, D., Farhi, J., Dicker, D., Ashkenazi, J., Shelef, M. and Goldman J.A. (1990) The impact of embryo quality on pregnancy outcome in elderly women undergoing in vitro fertilization-embryo transfer (IVF-ET). Journal of in Vitro Fertilization and Embryo Transfer, 7, 257-261. doi:10.1007/BF01129530
[18] McAVey, B., Zapantis, A., Jindal, S.K., Lieman, H.J. and Polotsky, A.J. (2001) How many eggs are needed to produce an assisted reproductive technology baby: Is more always better? Fertility and Sterility, 96, 332-335.
[19] Hu, Y., Maxson, W.S., Hoffman, D.I., Ory, S.J., Eager, S., Dupre, J. and Lu, C. (1998) Maximizing pregnancy rates and limiting higher-order multiple conceptions by determining the optimal number of embryos to transfer based on quality. Fertility and Sterility, 69, 650-657. doi:10.1016/S0015-0282(98)00024-7
[20] Dickey, R.P., Olar, T.T., Taylor, S.N., Curole, D.N. and Harrigill, K. (1993) Relationship of biochemical pregnancy to pre-ovulatory endometrial thickness and pattern in patients undergoing ovulation induction. Human Reproduction, 8, 327-330
[21] Schild, R.L., Knobloch, C., Dorn, C., Fimmers, R., van der Ven, H. and Hansmann, M. (2001) Endometrial receptivity in an in vitro fertilization program as assessed by spiral artery blood ?ow, endometrial thickness, endometrial volume, and uterine artery blood ?ow. Fertility and Sterility, 75, 361-366. doi:10.1016/S0015-0282(00)01695-2
[22] Munné, S., Alikani, M., Tomkin, G., Grifo, J. and Cohen, J. (1995) Embryo morphology, developmental rates, and maternal age are correlated with chromosome abnormalities. Fertility and Sterility, 64, 382-391.
[23] Nikbakht, N. and Hemadi, M. (2012) Comparison of two doses of recombinant human chorionic gonadotropin (rhCG) during ovulation induction in intrauterine insemination cycles: A prospective randomized clinical trial. International Journal of Pharmacology, 8, 259-264. doi:10.3923/ijp.2012. 259.264

  
comments powered by Disqus

Copyright © 2019 by authors and Scientific Research Publishing Inc.

Creative Commons License

This work and the related PDF file are licensed under a Creative Commons Attribution 4.0 International License.