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Assessment of Secondary Metabolites from Marine-Derived Fungi as Antioxidant

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DOI: 10.4236/ojmc.2013.33009    3,994 Downloads   8,676 Views   Citations

ABSTRACT

Marine derived fungi are considered as a promising source of novel drugs due to their biodiversity and consequent chemo-diversity. Although marine microorganisms especially fungi are not well defined taxonomically, making this a promising frontier for the discovery of new medicines. This study focused on marine derived fungi as a model for bioactive exploration for new entities with anti-inflammatory and antioxidant capacity. Three in-vitro assays were used to investigate the bioactive antioxidant potentiality of fungal extracts. Thiobarbituric acid (TBARS),α,α-Diphenyl-β- picrylhydrazyl (DPPH) and NO assay are based on their total phenolic and flavonoid content of each extract group. Ch. globosum recorded the highest antioxidant activity (92.82%) in TBARS assay, while G. dankaliensis came first by recording 59.28% in DPPH assay in comparison with ascorbic acid (61.83%). In NO inhibition assay, N. oryzae showed 49.3% comparing with ascorbic acid (73.12%). From the preliminary result of our extracts, we can consider the marine derived fungi extracts as promising antioxidant and anti-inflammatory drug candidate.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

N. Abdel-Monem, A. Abdel-Azeem, E. El Ashry, D. Ghareeb and A. Nabil-Adam, "Assessment of Secondary Metabolites from Marine-Derived Fungi as Antioxidant," Open Journal of Medicinal Chemistry, Vol. 3 No. 3, 2013, pp. 60-73. doi: 10.4236/ojmc.2013.33009.

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