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The Effects of N-acetyl-seryl-aspartyl-lysyl-proline on Expression of NF-κb and MCP-1 in Rats with Silicosis

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DOI: 10.4236/ijcce.2013.22B006    2,380 Downloads   3,599 Views  

ABSTRACT

In the present study, we developed silicosis of rat model by bronchial perfusion SiO2 dust, and intervenes with AcSDKP, immunohisto chemistry was used to detect NF-κb and MCP-1 expression in lung tissue, and positive cells were counted. We found that compared with silicotic model group, the positive cells of NF-κb and MCP-1 were decreased significantly in anti-fibrosis treatment of AcSDKP group. The findings suggest that AcSDKP could inhibit the expression of NF-κb and MCP-1 in lung tissue of silicosos, this may be related to AcSDKP inhibit of macrophage infiltration in lung tissue and reduced the degree of dust alveolitis.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Q. Li, F. Yang, L. J. Zhang, H. Xu and W. L. Zhang, "The Effects of N-acetyl-seryl-aspartyl-lysyl-proline on Expression of NF-κb and MCP-1 in Rats with Silicosis," International Journal of Clean Coal and Energy, Vol. 2 No. 2B, 2013, pp. 24-26. doi: 10.4236/ijcce.2013.22B006.

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