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Field evaluation of KO-Tab 1-2-3® long lasting insecticidal net performance in Milenge, Zambia

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DOI: 10.4236/jbise.2013.67A1002    2,284 Downloads   3,461 Views   Citations

ABSTRACT

Insecticide treated nets (ITNs) play a pivotal role in the prevention and control of malaria. Conversely, inadequate levels of ownership, utilization and durability invariably compromise their efficacy. Operational performance of the KO-Tab 1-2-3 Long Lasting Insecticidal Nets (LLINs) was assessed using the World Health Organization (WHO) standard entomological and epidemiological procedures, and a pretested structured questionnaire. The median knock down time for Anopheles funestus s.l. was 30 minutes (95% CI 26.3 - 34.0). Post exposure mean mortality rates were 34% at one hour and 80.0% at 24 hours (OR = 0.13, P = 0.00002). Children between the ages of 1 - 4 years old exhibited higher false positives as compared to the 5 - 15 years age groups (OR = 0.10, P = 0.0006). Parasite prevalence varied between rapid diagnostic tests (RDTs) (40.4%) and microscopy (31.3%) (OR = 0.67, P = 0.2825) with 9.2% discordant RDT false positives. All malaria positive children were Plasmodium falciparum mono-infections. Hospital admissions reduced by 28% between 2005 and 2008, with case fatality rates reducing by 19% between 2006 and2007 inchildren under five years. No marked heterogeneity between LLINs ownership (66%) and utilization (48.3%) was observed (OR = 0.49, P = 0.0978). There was complete (100%) community level knowledge of KO-Tab 1-2-3 LLINs. The study provides evidence of potential of KO-Tab 1-2-3 LLINs for operational scale distribution, and substantiates the need for further longitudinal studies to monitor their insecticidal and physical durability.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Chanda, E. , Kandyata, A. , Chanda, J. and Chanda-Kapata, P. (2013) Field evaluation of KO-Tab 1-2-3® long lasting insecticidal net performance in Milenge, Zambia. Journal of Biomedical Science and Engineering, 6, 4-10. doi: 10.4236/jbise.2013.67A1002.

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