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Thermal Decomposition of Some Cardiovascular Drugs (Telmisartane, Cilazapril and Terazosin HCL)

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DOI: 10.4236/ajac.2013.47042    3,192 Downloads   4,996 Views   Citations

ABSTRACT

Thermal analysis of some antihypertensive drugs, Telmisartan, Cilazapril and Terazosin HCL was achieved. Thermogravimetry, derivative thermogravimetry and differential thermal analysis were used through the work. Thermogravimetric parameters such as activation energy, frequency factor and reaction order were calculated. The results show the stability value decrease in the order Telmisartan > Cilazapril > Terazosin. This method can be used in the quality control of pharmaceutical compounds because it is simple, fast and cheap.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

L. Al-Harbi, E. El-Mossalamy, A. Obaid and M. EL-RIES, "Thermal Decomposition of Some Cardiovascular Drugs (Telmisartane, Cilazapril and Terazosin HCL)," American Journal of Analytical Chemistry, Vol. 4 No. 7, 2013, pp. 337-342. doi: 10.4236/ajac.2013.47042.

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