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Human Long Telomeres and Epigenetic Marks

DOI: 10.4236/cellbio.2013.22009    2,689 Downloads   5,328 Views  

ABSTRACT

We have read with interest the article “Telomere length regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1α” by Arnoult and colleagues [1]. This study focuses on human telomeric chromatin structure using different techniques like Chromatin Immunoprecipitation (ChIP), cytolocalization or RT-qPCR. However, it has been performed without taking into consideration the presence of Interstitial Telomeric Sequences (ITSs) in the human genome. Some of the conclusions of the article are undoubtedly clear but there are others that might be explained in alternative ways, considering the existence of ITSs. Following, we mention some comments that arise from this interesting article.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

M. Vaquero-Sedas and M. Vega-Palas, "Human Long Telomeres and Epigenetic Marks," CellBio, Vol. 2 No. 2, 2013, pp. 70-72. doi: 10.4236/cellbio.2013.22009.

References

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[12] M. Vaquero-Sedas, F. Gámez-Arjona and M. Vega-Palas, “Arabidopsis thaliana Telomeres Exhibit Euchromatic Features,” Nucleic Acids Research, Vol. 39, 2011, pp. 2007-2017. doi:10.1093/nar/gkq1119
[13] M. Vaquero-Sedas, C. Luo and M. Vega-Palas, “Analysis of the Epigenetic Status of Telomeres by Using ChIP-seq Data,” Nucleic Acids Research, Vol. 40, 2012, e163. doi:10.1093/nar/gks730
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[15] M. Vega-Palas and M. Vaquero-Sedas, “Integrating Telomeres into Genome-Wide ChIP-seq Analyses,” Protocol Exchange, 2013. doi:10.1038/protex.2013.039

  
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