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Short-Term Outcomes in Heart Transplant Recipients Treated with Generic Tacrolimus Compared to Prograf

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DOI: 10.4236/ojots.2013.32004    3,536 Downloads   6,018 Views   Citations


Calcineurin inhibitors are the cornerstone of solid organ transplant immunosuppression. Tacrolimus has only recently become available in a non-branded formulation, and there is little data on the efficacy and safety of generic tacrolimus, particularly following heart transplant. We performed a retrospective analysis of 21 consecutive patients who were treated with generic tacrolimus following heart transplant and compared rate of biopsy-proven acute cellular rejection to historical controls who were treated with Prograf. No significant difference in biopsy-proven acute cellular rejection was noted between the groups and rates of opportunistic infection and death were comparable. Although limited by the single-center, retrospective design, this preliminary data may be useful to clinicians facing the option of initiating generic tacrolimus following heart transplant.

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The authors declare no conflicts of interest.

Cite this paper

Dhungel, V. , Colvin-Adams, M. and Eckman, P. (2013) Short-Term Outcomes in Heart Transplant Recipients Treated with Generic Tacrolimus Compared to Prograf. Open Journal of Organ Transplant Surgery, 3, 19-21. doi: 10.4236/ojots.2013.32004.


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