|
[1]
|
Forrester, K., Almoguera, C., Han, K., et al. (1987) Detection of high incidence of K-ras oncogenes during human colon tumorigenesis. Nature, 327, 298-303.
doi:10.1038/327298a0
|
|
[2]
|
Ionov, Y., Peinado, M.A., Malkhosyan, S., et al. (1993) Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature, 363, 558-561. doi:10.1038/363558a0
|
|
[3]
|
Cui, H., Horon, I.L., Ohlsson, R., et al. (1998) Loss of imprinting in normal tissue of colorectal cancer patients with microsatellite instability. Nature Medicine, 4, 1276-1280. doi:10.1038/3260
|
|
[4]
|
Vogelstein, B., Fearon, E.R., Hamilton, S.R., et al. (1988) Genetic alterations during colorectal-tumor development. New England Journal of Medicine, 319, 525-532.
doi:10.1056/NEJM198809013190901
|
|
[5]
|
Kitahara, O., Furukawa, Y., Tanaka, T., et al. (2001) Alterations of gene expression during colorectal carcinogenesis revealed by cDNA microarrays after laser-capture microdissection of tumor tissues and normal epithelia. Cancer Research, 61, 3544-3549.
|
|
[6]
|
Lin, Y.M., Furukawa, Y., Tsunoda, T., et al. (2002) Molecular diagnosis of colorectal tumors by expression profiles of 50 genes expressed differentially in adenomas and carcinomas. Oncogene, 21, 4120-4128.
doi:10.1038/sj.onc.1205518
|
|
[7]
|
Zou, T.T., Selaru, F.M., Xu, Y., et al. (2002) Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon. Oncogene, 21, 4855-4862.
doi:10.1038/sj.onc.1205613
|
|
[8]
|
Kwon, H.C., Kim, S.H., Roh, M.S., et al. (2004) Gene expression profiling in lymph node-positive and lymph node-negative colorectal cancer. Diseases of the Colon & Rectum, 47, 141-152. doi:10.1007/s10350-003-0032-7
|
|
[9]
|
Friederichs, J., Rosenberg, R., Mages, J., et al. (2005) Gene expression profiles of different clinical stages of colorectal carcinoma: Toward a molecular genetic understanding of tumor progression. International Journal of Colorectal Disease, 20, 391-402.
doi:10.1007/s00384-004-0722-1
|
|
[10]
|
Kim, K., Park, U., Wang, J., et al. (2008) Gene profiling of colonic serrated adenomas by using oligonucleotide microarray. International Journal of Colorectal Disease, 23, 569-580. doi:10.1007/s00384-008-0451-y
|
|
[11]
|
Kita, H., Hikichi, Y., Hikami, K., et al. (2006) Differential gene expression between flat adenoma and normal mucosa in the colon in a microarray analysis. Journal of Gastroenterology, 41, 1053-1063.
doi:10.1007/s00535-006-1894-y
|
|
[12]
|
Agrawal, D., Chen, T.G., Irby, R., et al. (2002) Osteopontin identified as lead marker of colon cancer progression, using pooled sample expression profiling. Journal of the National Cancer Institute, 94, 513-521.
doi:10.1093/jnci/94.7.513
|
|
[13]
|
Koehler, A., Bataille, F., Schmid, C., et al. (2004) Gene expression profiling of colorectal cancer and metastases divides tumours according to their clinicopathological stage. Journal of Pathology, 204, 65-74.
doi:10.1002/path.1606
|
|
[14]
|
Yanagawa, R., Furukawa Y., Tsunoda T., et al. (2001) Genome-wide screening of genes showing altered expression in liver metastases of human colorectal cancers by cDNA microarray. Neoplasia, 3, 395-401.
doi:10.1038/sj.neo.7900185
|
|
[15]
|
Ki, D.H., Jeung, H.C., Park, C.H., et al. (2007) Whole genome analysis for liver metastasis gene signatures in colorectal cancer. International Journal of Cancer, 121, 2005-2012. doi:10.1002/ijc.22975
|
|
[16]
|
Lin, H.M., Chatterjee, A., Lin, Y.H., et al. (2007) Genome wide expression profiling identifies genes associated with colorectal liver metastasis. Oncology Reports, 17, 1541-1549
|
|
[17]
|
Watanabe, T., Kobunai, T., Tanaka, T., et al. (2009) Gene expression signature and the prediction of lymph node metastasis in colorectal cancer by DNA microarray. Diseases of the Colon & Rectum, 52, 1941-1948.
doi:10.1007/DCR.0b013e3181b53684
|
|
[18]
|
Wang, Y., Jatkoe, T., Zhang, Y., et al. (2004) Gene expression profiles and molecular markers to predict recurrence of Dukes’ B colon cancer. Journal of Clinical Oncology, 22, 1564-1571. doi:10.1200/JCO.2004.08.186
|
|
[19]
|
Birkenkamp-Demtroder, K., Olesen, S.H., Sorensen, F.B. et al. (2005) Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid. Gut, 54, 374-384. doi:10.1136/gut.2003.036848
|
|
[20]
|
Ghadimi, B.M., Grade, M., Difilippantonio, M.J., et al. (2005) Effectiveness of gene expression profiling for response prediction of rectal adenocarcinomas to preoperative chemoradiotherapy. Journal of Clinical Oncology, 23, 1826-1838. doi:10.1200/JCO.2005.00.406
|
|
[21]
|
Kim, I.J., Lim, S.B., Kang, H.C., et al. (2007) Microarray gene expression profiling for predicting complete response to preoperative chemoradiotherapy in patients with advanced rectal cancer. Diseases of the Colon & Rectum, 50, 1342-1353. doi:10.1007/s10350-007-277-7
|
|
[22]
|
Mariadason, J.M., Arango, D., Shi, Q.H., et al. (2003) Gene expression profiling-based prediction of response of colon carcinoma cells to 5-fluorouracil and camptothecin. Cancer Research, 63, 8791-8812
|
|
[23]
|
Del Rio, M., Molina, F., Mollevi, C.B., et al. (2007) Gene expression signature in advanced colorectal cancer patients select drugs and response for the use of leucovorin, fluorouracil, and irinotecan. Journal of Clinical Oncology, 25, 773-780. doi:10.1200/JCO.2006.07.4187
|
|
[24]
|
Khambata-Ford, S., Garrett C.R., Meropol N.J., et al. (2007) Expression of epiregulin and amphiregulin and Kras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. Journal of Clinical Oncology, 25, 3230-3237.
doi:10.1200/JCO.2006.10.5437
|
|
[25]
|
Kim, I.J., Lim, S.B., Kang, H.C., et al. (2007) Microarray gene expression profiling for predicting complete response to preoperative chemoradiotherapy in patients with advanced rectal cancer. Diseases of the Colon & Rectum, 50, 1342-1353. doi:10.1007/s10350-007-277-7
|
|
[26]
|
Rimkus, C., Friederichs, J., Boulesteix, A.L., et al. (2008) Microarray-based prediction of tumor response to neoadjuvant radiochernotherapy of patients with locally advanced rectal cancer. Clinical Gastroenterology and Hepatology, 6, 53-61. doi:10.1016/j.cgh.2007.10.022
|
|
[27]
|
Spitzner, M., Emons, G., Kramer, F., et al. (2010) A gene expression signature for chemoradiosensitivity of colorectal cancer cells. International Journal of Radiation Oncology, Biology, Physics, 78, 1184-1192.
doi:10.1016/j.ijrobp.2010.06.023
|
|
[28]
|
Cunningham, D., Humblet, Y., Siena, S., et al. (2004) Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. New England Journal of Medicine, 351, 337-345.
doi:10.1056/NEJMoa033025
|
|
[29]
|
Hurwitz, H., Fehrenbacher, L., Novotny, W., et al. (2004) Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. New England Journal of Medicine, 350, 2335-2342.
doi:10.1056/NEJMoa032691
|
|
[30]
|
Mayer, R.J. (2009) Targeted therapy for advanced colorectal cancer-more is not always better. New England Journal of Medicine, 360, 623-625.
doi:10.1056/NEJMe0809343
|
|
[31]
|
Saltz, L.B., Meropol, N.J., Loehrer, P.J. et al. (2004) Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. Journal of Clinical Oncology, 22, 1201-1208. doi:10.1200/JCO.2004.10.182
|
|
[32]
|
Waldner, M.J. and Neurath, M.F. (2010) The molecular therapy of colorectal cancer. Molecular Aspects of Medicine, 31, 171-178. doi:10.1016/j.mam.2010.02.005
|
|
[33]
|
Lee, R.C., Feinbaum, R.L. and Ambros, V. (1993) The C-elegans heterochronic gene lin-4 encodes small rnas with antisense complementarity to lin-14. Cell, 75, 843-854. doi:10.1016/0092-8674(93)90529-Y
|
|
[34]
|
Brennecke, J., Hipfner, D.R. and Stark, A. et al. (2003) Bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell, 113, 25-36.
doi:10.1016/S0092-8674(03)00231-9
|
|
[35]
|
Lagos-Quintana, M., Rauhut, R., Yalcin, A. et al. (2002) Identification of tissue-specific microRNAs from mouse. Current Biology, 12, 735-739.
doi:10.1016/S0960-9822(02)00809-6
|
|
[36]
|
Calin, G.A., Dumitru, C.D., Shimizu, M. et al. (2002) Frequent deletions and down-regulation of microRNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proceedings of the National Academy of Sciences of the United States of America, 99, 15524-15529.
doi:10.1073/pnas.242606799
|
|
[37]
|
Michael, M.Z., O’Connor, S.M., Pellekaan, N.G.V., et al. (2003) Reduced accumulation of specific microRNAs in colorectal neoplasia. Molecular Cancer Research, 1, 882-891.
|
|
[38]
|
Schetter, A.J., Leung, S.Y., Sohn, J.J. et al. (2008) MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. Jama-Journal of the American Medical Association, 299, 425-436. doi:10.1001/jama.299.4.425
|
|
[39]
|
Akao, Y., Nakagawa, Y. and Naoe T. (2007) MicroRNA-143 and-145 in colon cancer. DNA and Cell Biology, 26, 311-320. doi:10.1089/dna.2006.0550
|
|
[40]
|
Braun, C.J., Zhang, X., Savelyeva, I., et al. (2008) P53-responsive microRNAs 192 and 215 are capable of inducing cell cycle arrest. Cancer Research, 68, 10094-10104. doi:10.1158/0008-5472.CAN-08-1569
|
|
[41]
|
He, X.Y., He, L. and Hannon, G.J. (2007) The guardian’s little helper: MicroRNAs in the p53 tumor suppressor network. Cancer Research, 67, 11099-11101.
doi:10.1158/0008-5472.CAN-07-2672
|
|
[42]
|
Wang, P., Zou, F., Zhang, X. et al. (2009) MicroRNA-21 negatively regulates cdc25A and cell cycle progression in colon cancer cells. Cancer Research, 69, 8157-8165. doi:10.1158/0008-5472.CAN-09-1996
|
|
[43]
|
Asangani, I.A., Rasheed, S.A.K., Nikolova, D.A. et al. (2008) MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene, 27, 2128-2136. doi:10.1038/sj.onc.1210856
|
|
[44]
|
Nagel, R., Le Sage, C., Diosdado, B. et al. (2008) Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer. Cancer Research, 68, 5795-5802. doi:10.1158/0008-5472.CAN-08-0951
|
|
[45]
|
Guo, C.G., Sah, J.F., Beard, L., et al. (2008) The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers. Genes Chromosomes & Cancer, 47, 939-946.
doi:10.1002/gcc.20596
|
|
[46]
|
Bandres, E., Cubedo, E., Agirre, X., et al. (2006) Identification by Real-time PCR of 13 mature microRNAs differentially expressed in colorectal cancer and nontumoral tissues. Molecular Cancer, 5, 29.
|
|
[47]
|
Xi Y., Formentini, A., Chien, M., et al. (2006) Prognostic values of microRNAs in colorectal cancer. Biomark Insights, 2, 113-121.
|
|
[48]
|
Arndt, G.M., Dossey, L., Cullen, L.M. et al. (2009) Characterization of global microRNA expression reveals oncogenic potential of miR-145 in metastatic colorectal cancer. BMC Cancer, 9, 374.
|
|
[49]
|
Motoyama, K., Inoue, H., Takatsuno, Y., et al. (2009) Over-and under-expressed microRNAs in human colorectal cancer. International Journal of Oncology, 34, 1069-1075.
|
|
[50]
|
Wang, C.J., Zhou, Z.G., Wang, L. et al. (2009) Clinicopathological significance of microRNA-31,-143 and-145 expression in colorectal cancer. Disease Markers, 26, 27-34.
|
|
[51]
|
Lanza, G., Ferracin, M., Gafa, R. et al. (2007) MRNA/ microRNA gene expression profile in microsatellite unstable colorectal cancer. Molecular Cancer, 6, 54.
|
|
[52]
|
Kloosterman, W.P., Lagendijk, A.K., Ketting, R.F. et al. (2007) Targeted inhibition of miRNA maturation with morpholinos reveals a role for miR-375 in pancreatic islet development. Plos Biology, 5, 1738-1749.
doi:10.1371/journal.pbio.0050203
|
|
[53]
|
Hutvagner, G. and Zamore P.D. (2002) A microRNA in a multiple-turnover RNAi enzyme complex. Science, 297, 2056-2060. doi:10.1126/science.1073827
|
|
[54]
|
Elmen, J., Lindow, M., Silahtaroglu, A. et al. (2008) Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver. Nucleic Acids Research, 36, 1153-1162. doi:10.1093/nar/gkm1113
|
|
[55]
|
Krutzfeldt, J., Rajewsky, N., Braich, R. et al. (2005) Silencing of microRNAs in vivo with “antagomirs”. Nature, 438, 685-689. doi:10.1038/nature04303
|
|
[56]
|
Brosens, L.A.A., Van Hattem, W.A., Jansen, M. et al. (2007) Gastrointestinal polyposis syndromes. Current Molecular Medicine, 7, 29-46.
doi:10.2174/156652407779940404
|
|
[57]
|
Lu, Z., Liu, M., Stribinskis, V. et al. (2008) MicroRNA21 promotes cell transformation by targeting the programmed cell death 4 gene. Oncogene, 27, 4373-4379.
doi:10.1038/onc.2008.72
|
|
[58]
|
Dews, M., Homayouni, A., Yu, D. et al. (2006) Augmentation of tumor angiogenesis by a Myc-activated micro-RNA cluster. Nature Genet, 38, 1060-1065.
doi:10.1038/ng1855
|
|
[59]
|
Rossi, L., Bonmassar, E. and Faraoni, I. (2007) Modification of miR gene expression pattern in human colon cancer cells following exposure to 5-fluorouracil in vitro. Pharmacological Research, 56, 248-253.
doi:10.1016/j.phrs.2007.07.001
|
|
[60]
|
Meng, F.Y., Henson, R., Lang, M. et al. (2006) Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines. Gastroenterology, 130, 2113-2129.
doi:10.1053/j.gastro.2006.02.057
|