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Remotely activated, vibrational magnetoelastic array system for controlling cell adhesion

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DOI: 10.4236/jbise.2013.64060    2,797 Downloads   4,190 Views   Citations

ABSTRACT

A new system was designed to selectively control cellular adhesion to medical implants. The system is based on magnetoelastic (ME) materials that can be remotely set to generate mechanical vibrations at submicron levels with predetermined amplitude and frequency. Previous studies have demonstrated the capacity of these vibrations to control cellular adhesion at a substrate surface. In this work, an ME film with two conjoined strips was developed to investigate the potential of this system to provide region specific control of cellular adhesion. In vitro cell culture experiments performed with L929 fibroblasts indicate that cellular adhesion can be increased or decreased at different regions of the film by changing the frequency of the magnetic field.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Trierweiler, S. , Holmes, H. , Pereles, B. , Rajachar, R. and Ong, K. (2013) Remotely activated, vibrational magnetoelastic array system for controlling cell adhesion. Journal of Biomedical Science and Engineering, 6, 478-482. doi: 10.4236/jbise.2013.64060.

References

[1] Wynn, T.A. (2008) Cellular and molecular mechanisms of fibrosis. The Journal of Pathology, 214, 199-210. doi:10.1002/path.2277
[2] Van Luyn, M.J.A., Harmsen, M. and Luttikhuizen, D. (2006) Cellular and molecular dynamics in the foreign body reaction. Tissue Engineering, 12, 1955-1970. doi:10.1089/ten.2006.12.1955
[3] Liu, X.M., Lim, J.Y., Donahue, H.J., Dhurjati, R., Mastro, A.M. and Vogler, E.A. (2007) Influence of substratum surface chemistry/energy and topography on the human fetal osteoblastic cell line hFOB 1.19: Phenotypic and genotypic responses observed in vitro. Biomaterials, 28, 4535-4550. doi:10.1016/j.biomaterials.2007.06.016
[4] Khang, G., Lee, S.J., Lee, J.H., Kim, Y.S. and Lee, H.B. (1999) Interaction of fibroblast cells on poly(lactide-coglycolide) surface with wettability chemogradient. Bio- Medical Materials and Engineering, 9, 179-187.
[5] Webb, K., Hlady, V. and Tresco, P.A. (1998) Relative importance of surface wettability and charged functional groups on NIH 3T3 fibroblast attachment, spreading, and cytoskeletal organization. Journal of Biomedical Materials Research, 41, 422-430.
[6] Chen, C.J., Tan, J. and Tien, J. (2004) Mechanotransduction at cell-matrix and cell-cell contacts. Annual Review of Biomedical Engineering, 6, 275-302. doi:10.1146/annurev.bioeng.6.040803.140040
[7] Wilson, C.J., Clegg, R.E., Leavesley, D.I. and Pearcy, M.J. (2005) Mediation of biomaterial-cell interactions by adsorbed proteins: A review. Tissue Engineering, 11, 1- 18. doi:10.1089/ten.2005.11.1
[8] Vlaisavljevich, E., Janka, L.P., Ong, K.G. and Rajachar, R.M. (2011) Magnetoelastic materials as novel bioactive coatings for the control of cell adhesion. IEEE Transactions on Biomedical Engineering, 58, 698-704. doi:10.1109/TBME.2010.2093131
[9] Holmes, H., Tan, E.L., Ong, K.G. and Rajachar, R.M. (2011) Real-time, in vivo investigation of mechanical stimulus on cells with remotely activated, vibrational magnetoelastic layers. IEEE Engineering in Medicine and Biology Society Annual International Conference, 3979- 3982.
[10] Holmes, H.R., Tan, E.L., Ong, K.G. and Rajachar, R.M. (2012) Fabrication of biocompatible. Vibrational magnetoelastic materials for controlling cellular adhesion. Biosensors, 2, 57-69. doi:10.3390/bios2010057
[11] Ito, Y., Kimura, T., Ago, Y., Nam, K., Hiraku, K., Miyazaki, K., Masuzawa, T. and Kishida, A. (2011) Nano-vibration effect on cell adhesion and its shape. Bio-Medical Materials and Engineering, 21, 149-158.
[12] Wynn, T.A. (2008) Cellular and molecular mechanisms of fibrosis. The Journal of Pathology, 214, 199-210. doi:10.1002/path.2277
[13] Van Luyn, M.J.A., Harmsen, M. and Luttikhuizen, D. (2006) Cellular and molecular dynamics in the foreign body reaction. Tissue Engineering, 12, 1955-1970. doi:10.1089/ten.2006.12.1955
[14] Liu, X.M., Lim, J.Y., Donahue, H.J., Dhurjati, R., Mastro, A.M. and Vogler, E.A. (2007) Influence of substratum surface chemistry/energy and topography on the human fetal osteoblastic cell line hFOB 1.19: Phenotypic and genotypic responses observed in vitro. Biomaterials, 28, 4535-4550. doi:10.1016/j.biomaterials.2007.06.016
[15] Khang, G., Lee, S.J., Lee, J.H., Kim, Y.S. and Lee, H.B. (1999) Interaction of fibroblast cells on poly(lactide-coglycolide) surface with wettability chemogradient. Bio- Medical Materials and Engineering, 9, 179-187.
[16] Webb, K., Hlady, V. and Tresco, P.A. (1998) Relative importance of surface wettability and charged functional groups on NIH 3T3 fibroblast attachment, spreading, and cytoskeletal organization. Journal of Biomedical Materials Research, 41, 422-430.
[17] Chen, C.J., Tan, J. and Tien, J. (2004) Mechanotransduction at cell-matrix and cell-cell contacts. Annual Review of Biomedical Engineering, 6, 275-302. doi:10.1146/annurev.bioeng.6.040803.140040
[18] Wilson, C.J., Clegg, R.E., Leavesley, D.I. and Pearcy, M.J. (2005) Mediation of biomaterial-cell interactions by adsorbed proteins: A review. Tissue Engineering, 11, 1- 18. doi:10.1089/ten.2005.11.1
[19] Vlaisavljevich, E., Janka, L.P., Ong, K.G. and Rajachar, R.M. (2011) Magnetoelastic materials as novel bioactive coatings for the control of cell adhesion. IEEE Transactions on Biomedical Engineering, 58, 698-704. doi:10.1109/TBME.2010.2093131
[20] Holmes, H., Tan, E.L., Ong, K.G. and Rajachar, R.M. (2011) Real-time, in vivo investigation of mechanical stimulus on cells with remotely activated, vibrational magnetoelastic layers. IEEE Engineering in Medicine and Biology Society Annual International Conference, 3979- 3982.
[21] Holmes, H.R., Tan, E.L., Ong, K.G. and Rajachar, R.M. (2012) Fabrication of biocompatible. Vibrational magnetoelastic materials for controlling cellular adhesion. Biosensors, 2, 57-69. doi:10.3390/bios2010057
[22] Ito, Y., Kimura, T., Ago, Y., Nam, K., Hiraku, K., Miyazaki, K., Masuzawa, T. and Kishida, A. (2011) Nano-vibration effect on cell adhesion and its shape. Bio-Medical Materials and Engineering, 21, 149-158.

  
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