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Prevalence of Restless Legs Syndrome in Patients Treated with Peritoneal Dialysis: Clinical and Biochemical Characteristics among Patients with and without Restless Legs Syndrome

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DOI: 10.4236/ojneph.2013.31008    2,559 Downloads   4,817 Views   Citations

ABSTRACT

Introduction and Aims:This is a prospective study identifying prevalence of Restless Legs Syndrome (RLS) in patients ongoing peritoneal dialysis (PD) due to end stage renal disease (ESRD) and comparing clinical and biochemical characteristics among patients with and without RLS. Methods: Two hundred ESRD patients who received PD at least six months assessed by neurologist and nephrologist with regards to presence of RLS. Also, clinical and biochemical features of these patients are determined. One hundred and forty four patients were excluded from study because they had other secondary causes of RLS except for ESRD. Results: Thirteen of 56 patients (23.2%) had RLS. The use of vitamin B + folic acid supplements was significantly lower in patients with RLS than in those without RLS (69.2% vs 97.7%; p = 0.008). There was no significant difference between patient groups with and without RLS in terms of age, gender, body mass index, cause of ESRD, peritoneal membrane transport characteristic, smoking, consuming alcohol, use of erythropoietin, duration of PD, hemoglobin, serum calcium, serum phosphorus, serum albumin, levels of serum iron, total iron binding capacity, ferritin, folic acid and vitamin B12, transferrin saturation, weekly Kt/V urea value, and amount of residual urine volume (p > 0.05). Conclusion: RLS is more common among PD patients than general population. Although essential cause is not exactly known, use of folic acid and vitamin B complex decrease the RLS prevalence in this particular patient group.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

Korkmaz, S. , Tokgoz, B. , Ismailogullari, S. , Kocyigit, I. , Kocyigit, M. , Aksu, O. and Aksu, M. (2013) Prevalence of Restless Legs Syndrome in Patients Treated with Peritoneal Dialysis: Clinical and Biochemical Characteristics among Patients with and without Restless Legs Syndrome. Open Journal of Nephrology, 3, 44-50. doi: 10.4236/ojneph.2013.31008.

References

[1] K. A. Ekbom, “Restless Legs Syndrome,” Neurology, Vol. 10, 1960, pp. 868-873. doi:10.1212/WNL.10.9.868
[2] G. J. Lavigne and J. Y. Montplaisir, “Restless Legs Syndrome and Sleep Bruxism: Prevalence and Association among Canadians,” Sleep, Vol. 17, No. 8, 1994, pp. 739- 743.
[3] B. Phillips, T. Young, L. Finn, et al., “Epidemiology of Restless Legs Symptoms in Adults,” Archives of Internal Medicine, Vol. 160, No. 14, 2000, pp. 2137-2141. doi:10.1001/archinte.160.14.2137
[4] R. P. Allen, D. Picchietti, W. A. Hening, et al., “Restless Legs Syndrome: Diagnostic Criteria, Special Considerations and Epidemiology. A Report from the Restless Legs Syndrome Diagnosis and Epidemiology Workshop at the National Institutes of Health,” Sleep Medicine, Vol. 4, No. 2, 2003, pp. 101-119.
[5] M. Zucconi and L. Ferini-Strambi, “Epidemiology and Clinical Findings of Restless Legs Syndrome,” Sleep Medicine, Vol. 5, No. 3, 2004, pp. 293-299. doi:10.1016/j.sleep.2004.01.004
[6] R. P. Allen and C. J. Earley, “Restless Legs Syndrome: A Review of Clinical and Pathophysiologic Features,” Journal of Clinical Neurophysiology, Vol. 18, No. 2, 2001, pp. 128-147. doi:10.1097/00004691-200103000-00004
[7] L. A. Lopes, C. M. Lins, V. G. Adeodato, et al., “Restless Legs Syndrome and Quality of Sleep in Type 2 Diabetes,” Diabetes Care, Vol. 28, No. 11, 2005, pp. 2633-2636. doi:10.2337/diacare.28.11.2633
[8] M. Manconi, V. Govoni, A. De Vito, et al., “Pregnancy as a Risk Factor for Restless Legs Syndrome,” Sleep Medicine, Vol. 5, No. 3, 2004, pp. 305-308. doi:10.1016/j.sleep.2004.01.013
[9] B. Phillips, T. Young, L. Finn, et al., “Epidemiology of Restless Legs Symptoms in Adults,” Archives of Internal Medicine, Vol. 160, No. 14, 2000, pp. 2137-2141. doi:10.1001/archinte.160.14.2137
[10] N. C. Moreira, R. S. Damasceno, C. A. Medeiros, et al., “Restless Leg Syndrome, Sleep Quality and Fatigue in Multiple Sclerosis Patients,” Brazilian Journal of Medical and Biological Research, Vol. 41, No. 10, 2008, pp. 932-937. doi:10.1590/S0100-879X2008001000017
[11] T. Nomura, Y. Inoue, M. Miyake, et al., “Prevalence and Clinical Characteristics of Restless Legs Syndrome in Japanese Patients with Parkinson’s Disease,” Movement Disorders, Vol. 21, No. 3, 2006, pp. 380-384. doi:10.1002/mds.20734
[12] J. P. Bastos, R. B. Sousa, L. A. Nepomuceno, et al., “Sleep Disturbances in Patients on Maintenance Hemodialysis: Role of Dialysis Shift,” Revista da Associação Médica Brasileira, Vol. 53, No. 6, 2007, pp. 492-496. doi:10.1590/S0104-42302007000600014
[13] J. L. Holley, S. Nespor and R. Rault, “A Comparison of Reported Sleep Disorders in Patients on Chronic Hemodialysis and Continuous Peritoneal Dialysis,” American Journal of Kidney Diseases, Vol. 2, 1992, pp. 156-161.
[14] S. L. Walker, A. Fine and M. H. Kryger, “Sleep Complaints Are Common in Dialysis Unit,” American Journal of Kidney Diseases, Vol. 26, No. 5, 1995, pp. 751-756. doi:10.1016/0272-6386(95)90438-7
[15] J. W. Winkelman, G. M. Chertow and J. M. Lazarus, “Restless Legs Syndrome in End-Stage Renal Disease,” American Journal of Kidney Diseases, Vol. 28, No. 3, 1996, pp. 372-378. doi:10.1016/S0272-6386(96)90494-1
[16] V. Collado-Seidel, R. Kohnen, W. Samtleben, et al., “Clinical and Biochemical Findings in Uremic Patients with and without Restless Legs Syndrome,” American Journal of Kidney Diseases, Vol. 31, No. 2, 1998, pp. 324-328. doi:10.1053/ajkd.1998.v31.pm9469505
[17] D. S. C. Hui, T. Y. H. Wong, F. W. S. Ko, et al., “Prevalence of Sleep Disturbances in Chinese Patients with End- Stage Renal Failure on Continuous Ambulatory Peritoneal Dialysis,” American Journal of Kidney Diseases, Vol. 36, No. 4, 2000, pp. 783-788. doi:10.1053/ajkd.2000.17664
[18] Q. Huiqi, L. Shan and Q. Mingcai, “Restless Legs Syndrome (RLS) in Uremic Patients Is Related to the Frequency of Hemodialysis Sessions,” Nephron, Vol. 86, No. 4, 2000, p. 540. doi:10.1159/000045861
[19] M. Miranda, F. Araya, J. L. Castillo, et al., “Restless Legs Syndrome: A Clinical Study in Chilean General Population and in Uremic Patients,” Revista Médica de Chile, Vol. 129, 2001, pp. 179-186.
[20] M. L. Thorp, C. D. Morris and S. P. Bugby, “A Crossover Study of Gabapentin in Treatment of Restless Legs Syndrome among Hemodialysis Patients,” American Journal of Kidney Diseases, Vol. 38, No. 1, 2001, pp. 104-108. doi:10.1053/ajkd.2001.25202
[21] M. Sabbatini, B. Minale, A. Crispo, et al., “Insomnia in Maintenance Haemodialysis Patients,” Nephrology Dialysis Transplantation, Vol. 17, No. 5, 2002, pp. 852-856. doi:10.1093/ndt/17.5.852
[22] D. S. C. Hui, T. Y. H. Wong, T. S. T. Li, et al., “Prevalence of Sleep Disturbances in Chinese Patients with End Stage Renal Failure on Maintenenance Hemodialysis,” Medical Science Monitor, Vol. 8, No. 5, 2002, pp. 331-336.
[23] J. Takaki, T. Nishi, M. Nangaku, et al., “Clinical and Psychological Aspects of Restless Legs Syndrome in Uremic Patients on Hemodialysis,” American Journal of Kidney Diseases, Vol. 41, No. 4, 2003, pp. 833-839. doi:10.1016/S0272-6386(03)00031-3
[24] D. Bhowmik, M. Bhatia, S. Gupta, et al., “Restless Legs Syndrome in Hemodialysis Patients in India: A Case Controlled Study,” Sleep Medicine, Vol. 4, No. 2, 2003, pp. 143-146. doi:10.1016/S1389-9457(03)00005-4
[25] S. Akpinar, “Treatment of Restless Legs with Levodopa plus Benserazide,” Archives of Neurology, Vol. 39, No. 11, 1982, p. 739. doi:10.1001/archneur.1982.00510230065027
[26] J. Montplaisir, R. Godbout, G. Poirer, et al., “Restless Legs Syndrome and Periodic Movements in Sleep; Physiology and Treatment with L-Dopa,” Clinical Neuropharmacology, Vol. 9, No. 5, 1986, pp. 456-463. doi:10.1097/00002826-198610000-00006
[27] J. Winkelmann, J. Schadrack, T. Wetter, et al., “Opioid and Dopamine Antagonist Drug Challenges in Untreated Restless Legs Syndrome Patients,” Sleep Medicine, Vol. 2, No. 1, 2001, pp. 57-61. doi:10.1016/S1389-9457(00)00025-3
[28] M. Aksu and W. Bara-Jimenez, “State Dependent Excitability Changes of Spinal Flexor Reflex in Patients with Restless Legs Syndrome Secondary to Chronic Renal Failure,” Sleep Medicine, Vol. 2, No. 1, 2002, pp. 427-430. doi:10.1016/S1389-9457(02)00073-4
[29] R. L. Benz, M. R. Pressman, E. T. Hovick, et al., “A Preliminary Study of the Effects of Correction of Anemia with Recombinant Human Erythropoietin Therapy on Sleep, Sleep Disorders, and Daytime Sleepiness in Hemodialysis Patients (The SLEEPO Study),” American Journal of Kidney Diseases, Vol. 34, No. 6, 1999, pp. 1089-1095. doi:10.1016/S0272-6386(99)70015-6
[30] G. L. Gigli, M. Adorati, P. Dolso, et al., “Restless Legs Syndrome in End-Stage Renal Disease,” Sleep Medicine, Vol. 5, No. 3, 2004, pp. 309-315. doi:10.1016/j.sleep.2004.01.014
[31] N. G. Kutner, R. Zhang, Y. Huang, et al., “Racial Differences in Restless Legs Symptoms and Serum Ferritin in an Incident Dialysis Patient Cohort,” International Urology and Nephrology, Vol. 44, No. 6, 2012, pp. 1825-1831.
[32] G. Merlino, S. Lorenzut, G. Romano, et al., “Restless Legs Syndrome in Dialysis Patients: A Comparison between Hemodialysis and Continuous Ambulatory Peritoneal Dialysis,” Neurological Sciences, Vol. 33, No. 6, 2012, pp. 1311-1318.
[33] M. L. Unruh, A. S. Levey, C. D’Ambrosio, et al., “Restless Legs Symptoms among Incident Dialysis Patients: Association with Lower Quality of Life and Shorter Survival. Choices for Healthy Outcomes in Caring for End-Stage Renal Disease (CHOICE) Study,” American Journal of Kidney Diseases, Vol. 43, No. 5, 2004, pp. 900-909. doi:10.1053/j.ajkd.2004.01.013
[34] H. H. Al-Jahdali, W. A. Al-Qadhi, H. A. Khogeer, et al., “Restless Legs Syndrome in Patients on Dialysis,” Saudi Journal of Kidney Diseases and Transplantation, Vol. 20, No. 3, 2009, pp. 378-385.
[35] S. Siddiqui, M. Mak, D. Kavanagh, et al., “Restless Legs Syndrome in Haemodialysis Patients,” Scottish Renal Association, 9-10 May 2003.
[36] S. Roger, D. Harris and J. Stewart, “Possible Relation between Restless Legs and Anemia in Renal Dialysis Patients,” Lancet, Vol. 337, No. 8756, 1991, p. 1551. doi:10.1016/0140-6736(91)93248-8
[37] W. C. Chen, P. S. Lim, W. C. Wu, et al., “Sleep Behavior Disorders in a Large Cohort of Chinese (Taiwanese) Patients Maintained by Long-Term Hemodialysis,” American Journal of Kidney Diseases, Vol. 48, No. 2, 2006, pp. 277-284. doi:10.1053/j.ajkd.2006.04.079
[38] S. M. Araujo, V. M. de Bruin, L. A. Nepomuceno, et al., “Restless Legs Syndrome in End-Stage Renal Disease: Clinical Characteristics and Associated Comorbidities,” Sleep Medicine, Vol. 11, No. 8, 2010, pp. 785-790. doi:10.1016/j.sleep.2010.02.011
[39] C. Quinn, M. Uzbeck, I. Saleem, et al., “Iron Status and Chronic Kidney Disease Predict Restless Legs Syndrome in an Older Hospital Population,” Sleep Medicine, Vol. 12, No. 3, 2011, pp. 295-301. doi:10.1016/j.sleep.2010.08.014
[40] A. Kawauchi, Y. Inoue, T. Hashimoto, et al., “Restless Legs Syndrome in Hemodialysis Patients: Health-Related Quality of Life and Laboratory Data Analysis,” Clinical Nephrology, Vol. 66, No. 6, 2006, pp. 440-446.
[41] L. L. Lim, D. Dinner, K. W. Tham, et al., “Restless Legs Syndrome Associated with Primary Hyperparathyroidism,” Sleep Medicine, Vol. 6, No. 3, 2005, pp. 283-285. doi:10.1016/j.sleep.2004.10.014
[42] N. Kutner and D. Bliwise, “Restless Legs Complaint in African-American and Caucasian Hemodialysis Patients,” Sleep Medicine, Vol. 3, No. 6, 2002, pp. 497-500. doi:10.1016/S1389-9457(02)00025-4
[43] J. Perl, M. L. Unruh and C. T. Chan, “Sleep Disorders in End-Stage Renal Disease: ‘Markers of Inadequate Dialysis’?” Kidney International, Vol. 70, 2006, pp. 1687-1693. doi:10.1038/sj.ki.5001791
[44] J. L. Holley, S. Nespor and R. Rault, “Characterizing Sleep Disorders in Chronic Hemodialysis Patients,” ASAIO Transactions, Vol. 37, No. 3, 1991, pp. M456-M457.

  
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