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Association between an Incomplete Vaccination Schedule and Nosocomial Sepsis among Children with Cancer

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DOI: 10.4236/wjv.2013.31002    3,479 Downloads   5,970 Views   Citations

ABSTRACT

Background: Patients with cancer constitute a special group where immunization programs are often interrupted to begin treatment with chemotherapy. Sepsis is one of the main complications in this group. Methods: A hospital-based case-control study matched by age was carried out among subjects ≤ 9 years of age with cancer diagnosis. Children with cancer without sepsis and children with surgical pathology were included as controls; children with sepsis were included as cases. A bivariate logistic regression was used to determine the factors associated to nosocomial sepsis, and odds ratios were calculated with 95% confidence intervals. The percentage of attributable risk was calculated for the variables included in the final model. Results: Nineteen children with cancer and sepsis and 83 controls were included. Twelve (44%) caseshad an incomplete vaccination schedule according to their age. The association force between incomplete schedule and sepsis was 10.1 (95% CI, 3 - 36; p < 0.05). Conclusions: Approximately, 20% to 65% of the cases of serious nosocomial infection can be associated to an incomplete vaccination schedule. Strategies should be implemented to improve the general pediatric population’s vaccination status before a serious disease, such as cancer or another chronic condition preventing the application of vaccines, develops.

Conflicts of Interest

The authors declare no conflicts of interest.

Cite this paper

J. Reyna-Figueroa, D. PerezPeña-Rosas, P. Galindo-Delgado, A. Limon-Rojas and V. Madrid-Marina, "Association between an Incomplete Vaccination Schedule and Nosocomial Sepsis among Children with Cancer," World Journal of Vaccines, Vol. 3 No. 1, 2013, pp. 10-15. doi: 10.4236/wjv.2013.31002.

References

[1] R. Wilkinson, “The Impact of Inequality: How to Make Sick Societies Healthier,” Preventing Chronic Disease, Vol. 3, No. 1, 2006, pp. A26.
[2] A. P. de Leon, M. L. Garcia, M. C. Garcia, F. J. Gómez, J. L. Valdespino, G. Olaiz, R. Rojas, et al., “Tuberculosis and Diabetes in Southern Mexico,” Diabetes Care, Vol. 27, No. 7, 2004, pp. 1584-1590. doi:10.2337/diacare.27.7.1584
[3] V. Richardson, J. Hernandez, M. Quintanar, M. Esparza, B. Johnson, C. M. Gomez, U. Parashar and M. Patel, “Effect of Rotavirus Vaccination on Death from Childhood Diarrhea in Mexico,” The New England Journal of Medicine, Vol. 362 , No. 4, 2010, pp. 299-305. doi:10.1056/NEJMoa0905211
[4] D. A. Henderson, et al., “Smallpox as a Biological Weapon: Medical and Public Health Management,” Journal of the American Medical Association, Vol. 281, No. 22, 1999, pp. 2127-2137.
[5] V. Racaniello, One Hundred Years of Poliovirus Pathogenesis,” Virology, Vol. 344, No. 1, 2006, pp. 9-16
[6] M. L. NdeffoMbah, J. Liu, C. T. Bauch, Y. I. Tekel and J. Medlock, “The Impact of Imitation on Vaccination Behavior in Social Contact Networks,” PLoS Computational Biology, Vol. 8, No. 4, 2012, Article ID: 1002469. doi:10.1371/journal.pcbi.1002469
[7] F. Feng, D. Rosenbloom, L. Wang and M. Nowak, “Imitation Dynamics of Vaccination Behavior on Social Networks,” Proceedings of the Royal Society B: Biological Sciences, Vol. 278, No. 1702, 2011, pp. 42-49.
[8] N. Camille, M. Kotton and M. Poznansky, “Vaccination of Oncology Patients: An Effective Tool and an Opportunity Not to Be Missed,” The Oncologist, Vol. 17, No. 1, 2012, pp. 1-2. doi:10.1634/theoncologist.2011-0383
[9] P. Loulergue, O. Mir, J. Alexandre, et al., “Low Influenza Vaccination Rate among Patients Receiving Chemotherapy for Cancer,” Annals of Oncology, Vol. 19, No. 9, 2008, p. 1658. doi:10.1093/annonc/mdn531
[10] S. G. Martin, M. D. Mannino, S. Eaton and M. Moss, “The Epidemiology of Sepsis in the United States from 1979 through 2000,” The New England Journal of Medicine, Vol. 348, 2003, pp. 1546-1554. doi:10.1056/NEJMoa022139
[11] A. G.Freifeld and P. Pizzo, “Infectious, Complications in the Pediatric Cancer Patients,” In: P. Pizzo and D. Poplack, Eds., Principles and Practice of Pediatric Oncology, JB Lippincott Co., Filadelfia, 1993, pp. 987-992.
[12] V. Y. Dombrovskiy, A. A. Martin, J. Sunderram and H. L. Paz, “Rapid Increase in Hospitalization and Mortality Rates for Severe Sepsis in the United States: A Trend Analysis from 1993 to 2003,” Critical Care Medicine, Vol. 35, No. 5, 2007, pp. 1244-1250. doi:10.1097/01.CCM.0000261890.41311.E9
[13] D. C. Angus, W. T. Linde-Zwirble, J. Lidicker, G. Clermont, J. Carcillo and M. R. Pinsky, “Epidemiology of Severe Sepsis in the Unites States: Analysis of Incidence Outcome, and Associated Cost of Care,” Critical Care Medicine, Vol. 29, No. 7, 2001, pp. 1303-1310. doi:10.1097/00003246-200107000-00002
[14] F. R. Avila, G. L. Ramírez, A. C. Alpuche, G. J. L. Arredondo and P. J. I. Santos, “Infecciones Nosocomiales en un Hospital Pediátrico,” Salud Publica de México, Cuernavaca, 1986.
[15] A. G. Martínez, A. C. Anaya and F. C. Avila, “Incidencia de Bacteriemia y Neumonía Nosocomial en una Unidad de Pediatría,” Salud Publica de México, Cuernavaca, 2001. doi:10.1590/S0036-36342001000600001
[16] Instituto Nacional de Estadística y Geografía (INEGI) “Secretaría de Salud/Dirección General de Información en Salud, Base de Datos de Defunciones 2000-2008,” INEGI, Aguascalientes, 2010.
[17] B. Goldstein, B. Giroir, A. Randolph, et al., “International Pediatric Sepsis Consensus Conference: Definitions for Sepsis and Organ Dysfunction in Pediatrics,” The Pediatric Critical Care Medicine, 2005, Vol. 6, No. 1, 2005, pp. 2-8.
[18] J. S. Garner, W. R. Jarvis, T. G. Emori, T. C. Horan and J. M. Hughes, “CDC Definitions for Nosocomial Infections. In: R. N. Olmsted, ed., APIC Infection Control and Applied Epidemiology: Principles and Practice, Mosby, St. Louis, 1996, pp. A1-A20.
[19] J. V. Jani, C. De Schacht1, I. V Jani and G. Bjune, “Risk factors for Incomplete Vaccination and Missed Opportunity for Immunization in Rural Mozambique,” BMC Public Health, 2008, Vol. 8, No. 2, p. 161. doi:10.1186/1471-2458-8-161
[20] Centers for Disease Control and Prevention, “Prevención y Control de la influenza con Vacunas: Recomendaciones del Comité Asesor Sobre Prácticas de Inmunización (ACIP) 2011,” 2011 Morbidity and Mortality Weekly Report (MMWR), Druid Hills, 2011.
[21] Centers for Disease Control and Prevention, “Prevención y Control de la Influenza con Vacunas: Recomendaciones del Comité Asesor Sobre Prácticas de Inmunización (ACIP) 2010,” 2010 Morbidity and Mortality Weekly Report (MMWR), Druid Hills, 2010.
[22] G. L. G. Montalván, “Sepsis Severa y Shock Séptico en el Nino. Aún no Todo Está Dicho,” Pan American Journal of Public Health, Vol. 26, No. 6, 2009, pp. 562-564.
[23] F. J. Reyna, L. C. V. Richardson and V. P. Vidal “De las Definiciones, las Vacunas y la Identificación del Paciente Séptico en Pediatría,” Pan American Journal of Public Health, Vol. 27, No. 6, 2010, pp. 469-470. doi:10.1590/S1020-49892010000600010
[24] T. Lehrnbecher, C. Foster, N. Vázquez, C. L. Mackall and S. J. Chanock, “Therapy-Induced Alterations in Host Defense in Children Receiving Therapy for Cancer,” Journal of Pediatric Hematology/Oncology, Vol. 19, No. 5, 1997, pp. 399-417. doi:10.1097/00043426-199709000-00001
[25] P. A. Pizzo, “Management of Fever in Patients with Cancer and Treatment-Induced Neutropenia,” The New England Journal of Medicine 1993; Vol. 328, No. 18, pp. 1323-1332. doi:10.1056/NEJM199305063281808
[26] R. N. Jones, “Contemporary Antimicronial Susceptibility Pattems of Bacterial Pathogens Commonly Assoclated with Febrile Patients with Neutropenia,” Clinical Infectious Diseases, Vol. 29, No. 3, 1999, pp. 495-502. doi:10.1086/598621
[27] M. Macias, G. A. Jarquin, P. Gutierrez, M. A. Rodriguez, N. Gonzalez and P. Saltigeral, “Factores de Riesgo para Esquemas de Vacunación Incompletos en Ninos de 6 a 60 Meses en el Instituto Nacional de Pediatría,” Revista de Enfermedades Infecciosas en Pediatría, Vol. 22, No. 86, 2008, pp. 41-47.
[28] E. Holt, B. Guyer, N. Hughart, et al., “The Contribution of Missed Opportunities to Childhood Immunization in Baltimore,” Pediatrics, Vol. 97, No. 4, 1996, pp. 474-480.

  
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